Biodegradable, polymer encapsulated, metal oxide particles for MRI-based cell tracking.

Abstract:

:Metallic particles have shaped the use of magnetic resonance imaging (MRI) for molecular and cellular imaging. Although these particles have generally been developed for extracellular residence, either as blood pool contrast agents or targeted contrast agents, the coopted use of these particles for intracellular labeling has grown over the last 20 years. Coincident with this growth has been the development of metal oxide particles specifically intended for intracellular residence, and innovations in the nature of the metallic core. One promising nanoparticle construct for MRI-based cell tracking is polymer encapsulated metal oxide nanoparticles. Rather than a polymer coated metal oxide nanocrystal of the core: shell type, polymer encapsulated metal oxide nanoparticles cluster many nanocrystals within a polymer matrix. This nanoparticle composite more efficiently packages inorganic nanocrystals, affording the ability to label cells with more inorganic material. Further, for magnetic nanocrystals, the clustering of multiple magnetic nanocrystals within a single nanoparticle enhances r2 and r2* relaxivity. Methods for fabricating polymer encapsulated metal oxide nanoparticles are facile, yielding both varied compositions and synthetic approaches. This review presents a brief history into the use of metal oxide particles for MRI-based cell tracking and details the development and use of biodegradable, polymer encapsulated, metal oxide nanoparticles and microparticles for MRI-based cell tracking.

journal_name

Magn Reson Med

authors

Shapiro EM

doi

10.1002/mrm.25263

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

376-89

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

73

pub_type

杂志文章,评审
  • Development of an inductively coupled MR coil system for imaging and spectroscopic analysis of an implantable bioartificial construct at 11.1 T.

    abstract::Developing a method to noninvasively monitor tissue-engineered constructs is critical for the optimization of construct design and for assessing therapeutic efficacy. For this purpose, NMR is a powerful technique that can be used to obtain both images and spectroscopic data. But the inherent sensitivity of NMR limits ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22268

    authors: Volland NA,Mareci TH,Constantinidis I,Simpson NE

    更新日期:2010-04-01 00:00:00

  • Intensity correction of phased-array surface coil images.

    abstract::Phased-array coils distribute the high signal-to-noise ratio (SNR) performance of their small component surface coils over the larger area covered by the entire array. The inhomogeneous sensitivity profiles of the component surface coils result in images with very high signal near the phased-array and decreased signal...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910350419

    authors: Murakami JW,Hayes CE,Weinberger E

    更新日期:1996-04-01 00:00:00

  • Rapid T1 mapping of mouse myocardium with saturation recovery Look-Locker method.

    abstract::Dynamic contrast-enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look-Locker method was developed and validated for fast cardiac T(1) mapping in small animal models. By sampling the in...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22544

    authors: Li W,Griswold M,Yu X

    更新日期:2010-11-01 00:00:00

  • Proton NMR study of the state of water in fibrin gels, plasma, and blood clots.

    abstract::A proton NMR relaxation and pulsed field gradient self-diffusion study of water in fibrin gels, plasma, and blood clots has been performed with special emphasis on the effect of the sol-gel and shrinkage transitions. Deuteron NMR in fibrin gels was also studied to supplement the proton data. It is shown that a measure...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910140111

    authors: Blinc A,Lahajnar G,Blinc R,Zidansek A,Sepe A

    更新日期:1990-04-01 00:00:00

  • Brain water diffusion in normal and creatine-supplemented rats during transient global ischemia.

    abstract::Brain water diffusion in response to transient global ischemia (12 min), reperfusion (60 min), and cardiac arrest was monitored by localized proton magnetic resonance spectroscopy. The trace of the apparent diffusion coefficient tensor (ADC(Av)) was determined at high temporal resolution (10 sec) to assess the putativ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199910)42:4<798::aid-mrm23

    authors: Wick M,Fujimori H,Michaelis T,Frahm J

    更新日期:1999-10-01 00:00:00

  • Statistical artifacts in diffusion tensor MRI (DT-MRI) caused by background noise.

    abstract::This work helps elucidate how background noise introduces statistical artifacts in the distribution of the sorted eigenvalues and eigenvectors in diffusion tensor MRI (DT-MRI) data. Although it was known that sorting eigenvalues (principal diffusivities) by magnitude introduces a bias in their sample mean within a hom...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200007)44:1<41::aid-mrm8>3.0.co;

    authors: Basser PJ,Pajevic S

    更新日期:2000-07-01 00:00:00

  • Efficient biphasic spin-echo magnetic resonance imaging.

    abstract::The concept of temporal echo multiplexing is defined and used to develop rapid biphasic spin-echo sequences for imaging the heart. Three imaging sequences, based on four-echo and two-echo multiplexing and rapid single echo (i.e., conventional spin-echo imaging), are compared. Preliminary results indicate that two-echo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910110109

    authors: Parker DL,Caputo GR,Frederick PR

    更新日期:1989-07-01 00:00:00

  • Changes in T2*-weighted images during hyperoxia differentiate tumors from normal tissue.

    abstract::Experiments were performed to determine whether changes in T2*-weighted MR images during and after hyperoxia differentiate tumors from normal tissue. Mammary adenocarcinomas implanted in the right hind limbs of rats were studied. Gradient echo images were obtained at 2 Tesla with an evolution time of 20 ms and a recyc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910330306

    authors: Kuperman VYu,River JN,Lewis MZ,Lubich LM,Karczmar GS

    更新日期:1995-03-01 00:00:00

  • Complete elimination of the extracellular 23Na NMR signal in triple quantum filtered spectra of rat hearts in the presence of shift reagents.

    abstract::A method is suggested whereby the shifted extracellular triple quantum filtered 23Na signal of an isolated organ is completely eliminated. The method is based on the long relaxation time of the triple quantum coherence and on its fast evolution rate. When the carrier frequency is set on top of the intracellular sodium...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910300415

    authors: Navon G

    更新日期:1993-10-01 00:00:00

  • Deconvolution-based distortion correction of EPI using analytic single-voxel point-spread functions.

    abstract:PURPOSE:To develop a postprocessing algorithm that corrects geometric distortions due to spatial variations of the static magnetic field amplitude, B0 , and effects from relaxation during signal acquisition in EPI. THEORY AND METHODS:An analytic, complex point-spread function is deduced for k-space trajectories of EPI...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28591

    authors: Patzig F,Mildner T,Schlumm T,Müller R,Möller HE

    更新日期:2020-11-21 00:00:00

  • Fast nonlinear susceptibility inversion with variational regularization.

    abstract:PURPOSE:Quantitative susceptibility mapping can be performed through the minimization of a function consisting of data fidelity and regularization terms. For data consistency, a Gaussian-phase noise distribution is often assumed, which breaks down when the signal-to-noise ratio is low. A previously proposed alternative...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27073

    authors: Milovic C,Bilgic B,Zhao B,Acosta-Cabronero J,Tejos C

    更新日期:2018-08-01 00:00:00

  • Real-time Triggered RAdial Single-Shot Inversion recovery for arrhythmia-insensitive myocardial T1 mapping: motion phantom validation and in vivo comparison.

    abstract:PURPOSE:Cardiac T1 mapping has become an increasingly important imaging technique, contributing novel diagnostic options. However, currently utilized methods are often associated with accuracy problems because of heart rate variations and cardiac arrhythmia, limiting their value in clinical routine. This study aimed to...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27526

    authors: Gensler D,Salinger T,Düring M,Lorenz K,Jahns R,Wech T,Frantz S,Ertl G,Jakob PM,Nordbeck P

    更新日期:2019-03-01 00:00:00

  • A pitfall associated with lactate detection using stimulated-echo proton spectroscopy.

    abstract::At TE values of 136 ms, it has recently been shown that the lactate methyl signal, when obtained with a stimulated-echo (STE) sequence, is modulated at the zero-quantum (ZQ) frequency when TM is varied. Here we describe an additional modulation of the ZQ lactate signal, due to spin-spin coupling, that results in a 10-...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910170223

    authors: Sotak CH,Alger JR

    更新日期:1991-02-01 00:00:00

  • Evolution of the longitudinal magnetization for pulse sequences using a fast spin-echo readout: application to fluid-attenuated inversion-recovery and double inversion-recovery sequences.

    abstract::The fast spin-echo (FSE) sequence is frequently used as a fast data-readout technique in conjunction with other pulse sequence elements, such as in fluid-attenuated inversion-recovery (FLAIR) and double inversion-recovery (DIR) sequences. In order to implement those pulse sequences, an understanding is required of how...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20541

    authors: Meara SJ,Barker GJ

    更新日期:2005-07-01 00:00:00

  • Identification of signal bias in the variable flip angle method by linear display of the algebraic Ernst equation.

    abstract::A novel linear parameterization for the variable flip angle method for longitudinal relaxation time T(1) quantification from spoiled steady state MRI is derived from the half angle tangent transform, τ, of the flip angle. Plotting the signal S at coordinates x=Sτ and y=S/τ, respectively, establishes a line that render...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22849

    authors: Helms G,Dathe H,Weiskopf N,Dechent P

    更新日期:2011-09-01 00:00:00

  • A continuum of T 2 * components: Flexible fast fraction mapping in sodium MRI.

    abstract:PURPOSE:Parameter mapping in sodium MRI data is challenging due to inherently low SNR and spatial resolution, prompting the need to employ robust models and estimation techniques. This work aims to develop a continuum model of sodium T 2 ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27659

    authors: Syeda W,Blunck Y,Kolbe S,Cleary JO,Johnston LA

    更新日期:2019-06-01 00:00:00

  • Single-shot localized echo-planar imaging (STEAM-EPI) at 4.7 tesla.

    abstract::The resolution and homogeneity limitations of echo-planar imaging (EPI) are overcome by zoom imaging of an easily shimmed localized volume. Use of the stimulated echo enables single-shot localization. In vivo 0.5-mm resolution EPI images of selected regions of a cat brain at 4.7 T are presented. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910140225

    authors: Turner R,von Kienlin M,Moonen CT,van Zijl PC

    更新日期:1990-05-01 00:00:00

  • Ramped hybrid encoding for improved ultrashort echo time imaging.

    abstract:PURPOSE:We propose a new acquisition to minimize the per-excitation encoding duration and improve the imaging capability for short T2 * species. METHODS:In the proposed ramped hybrid encoding (RHE) technique, gradients are applied before the radiofrequency (RF) pulse as in pointwise encoding time reduction with radial...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25977

    authors: Jang H,Wiens CN,McMillan AB

    更新日期:2016-09-01 00:00:00

  • A new approach to autocalibrated dynamic parallel imaging based on the Karhunen-Loeve transform: KL-TSENSE and KL-TGRAPPA.

    abstract::TSENSE and TGRAPPA are autocalibrated parallel imaging techniques that can improve the temporal resolution and/or spatial resolution in dynamic magnetic resonance imaging applications. In its original form, TSENSE uses temporal low-pass filtering of the undersampled frames to create the sensitivity map. TGRAPPA uses a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22766

    authors: Ding Y,Chung YC,Jekic M,Simonetti OP

    更新日期:2011-06-01 00:00:00

  • Stability constants and 1H relaxation effects of ternary complexes formed between Gd-DTPA, Gd-DTPA-BMA, Gd-DOTA, and Gd-EDTA and citrate, phosphate, and carbonate ions.

    abstract::Formation of ternary complexes between Gd-DTPA, Gd-DTPA-BMA, and Gd-DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligibl...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910380120

    authors: Burai L,Hietapelto V,Király R,Tóth E,Brücher E

    更新日期:1997-07-01 00:00:00

  • Ultrashort TE T1rho (UTE T1rho) imaging of the Achilles tendon and meniscus.

    abstract::In this study, we report the use of a novel ultrashort echo time T(1)rhoT(1) sequence that combines a spin-lock preparation pulse with a two-dimensional ultrashort echo time sequence of a nominal echo time 8 microsec. The ultrashort echo time-T(1)rho sequence was employed to quantify T(1)rho in short T(2) tissues incl...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22474

    authors: Du J,Carl M,Diaz E,Takahashi A,Han E,Szeverenyi NM,Chung CB,Bydder GM

    更新日期:2010-09-01 00:00:00

  • Design of adiabatic selective pulses using optimal control theory.

    abstract::Optimal control theory has been applied in the past for the design of RF pulses for selective excitation. This was the outcome of having established the controllability of the MR spin system for the selective excitation problem. "Minimum distance" was the main formulation used for the solution. Because of their robust...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360311

    authors: Rosenfeld D,Zur Y

    更新日期:1996-09-01 00:00:00

  • A semiautomatic method for rapid segmentation of velocity-encoded myocardial magnetic resonance imaging data.

    abstract:PURPOSE:To develop a semiautomatic method for rapid segmentation of myocardial tissue phase mapping (TPM) data. METHODS:Manual segmentation of the myocardium was performed at end-diastole and end-systole. The points in both user-defined masks were then automatically tracked over the entire cardiac cycle using temporal...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26486

    authors: Espe EKS,Skårdal K,Aronsen JM,Zhang L,Sjaastad I

    更新日期:2017-09-01 00:00:00

  • Proton magnetic resonance spectroscopy of Sjögren-Larsson syndrome heterozygotes.

    abstract::A deficit of fatty alcohol:NAD+ oxidoreductase complex (FAO) activity has been detected in patients with the Sjögren-Larsson syndrome (SLS). A moderate decrease in FAO activity has also been reported in heterozygote SLS subjects. Abnormal peaks were detected with proton magnetic resonance spectroscopy (1H-MRS) in homo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1146

    authors: Kaminaga T,Mano T,Ono J,Kusuoka H,Nakamura H,Nishimura T

    更新日期:2001-06-01 00:00:00

  • Fe(III) distribution varies substantially within and between atherosclerotic plaques.

    abstract:PURPOSE:Vulnerable atherosclerotic plaques are structurally weak and prone to rupture, presumably due to local oxidative stress. Redox active iron is linked to oxidative stress and the aim of this study was to investigate the distribution of Fe(III) in carotid plaques and its relation to vulnerability for rupture. MET...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24687

    authors: Gustafsson H,Hallbeck M,Norell M,Lindgren M,Engström M,Rosén A,Zachrisson H

    更新日期:2014-02-01 00:00:00

  • Optimized 3D ultrashort echo time pulmonary MRI.

    abstract:PURPOSE:To optimize 3D radial ultrashort echo time MRI for high resolution whole-lung imaging. METHODS:3D radial ultrashort echo time was implemented on a 3T scanner to investigate the effects of: (1) limited field-of-view excitation, (2) variable density readouts, and (3) radial oversampling. Improvements in noise pe...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24570

    authors: Johnson KM,Fain SB,Schiebler ML,Nagle S

    更新日期:2013-11-01 00:00:00

  • Application of parallel imaging to fMRI at 7 Tesla utilizing a high 1D reduction factor.

    abstract::Gradient-echo EPI, blood oxygenation level-dependent (BOLD) functional MRI (fMRI) using parallel imaging (PI) is demonstrated at 7 Tesla with 16 channels, a fourfold 1D reduction factor (R), and fourfold maximal aliasing. The resultant activation detection in finger-tapping fMRI studies was robust, in full agreement w...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20934

    authors: Moeller S,Van de Moortele PF,Goerke U,Adriany G,Ugurbil K

    更新日期:2006-07-01 00:00:00

  • Self-navigated 4D cartesian imaging of periodic motion in the body trunk using partial k-space compressed sensing.

    abstract:PURPOSE:To enable fast and flexible high-resolution four-dimensional (4D) MRI of periodic thoracic/abdominal motion for motion visualization or motion-corrected imaging. METHODS:We proposed a Cartesian three-dimensional k-space sampling scheme that acquires a random combination of k-space lines in the ky/kz plane. A p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26406

    authors: Küstner T,Würslin C,Schwartz M,Martirosian P,Gatidis S,Brendle C,Seith F,Schick F,Schwenzer NF,Yang B,Schmidt H

    更新日期:2017-08-01 00:00:00

  • Low-rank plus sparse compressed sensing for accelerated proton resonance frequency shift MR temperature imaging.

    abstract:PURPOSE:To improve multichannel compressed sensing (CS) reconstruction for MR proton resonance frequency (PRF) shift thermography, with application to MRI-induced RF heating evaluation and MR guided high intensity focused ultrasound (MRgFUS) temperature monitoring. METHODS:A new compressed sensing reconstruction is pr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27666

    authors: Cao Z,Gore JC,Grissom WA

    更新日期:2019-06-01 00:00:00

  • The importance of correcting for signal drift in diffusion MRI.

    abstract:PURPOSE:To investigate previously unreported effects of signal drift as a result of temporal scanner instability on diffusion MRI data analysis and to propose a method to correct this signal drift. METHODS:We investigated the signal magnitude of non-diffusion-weighted EPI volumes in a series of diffusion-weighted imag...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26124

    authors: Vos SB,Tax CM,Luijten PR,Ourselin S,Leemans A,Froeling M

    更新日期:2017-01-01 00:00:00