Quantifying the intra- and extravascular contributions to spin-echo fMRI at 3 T.


:Functional MRI (fMRI) by means of spin-echo (SE) techniques provides an interesting alternative to gradient-echo methods because the contrast is based primarily on dynamic averaging associated with the blood oxygenation level-dependent (BOLD) effect. In this article the contributions from different brain compartments to BOLD signal changes in SE echo planar imaging (EPI) are investigated. To gain a better understanding of the underlying mechanisms that cause the fMRI contrast, two experiments are presented: First, the intravascular contribution is decomposed into two fractions with different regimes of flow by means of diffusion-weighting gradient schemes which are either flow-compensated, or will maximally dephase moving spins. Second, contributions from the intra- and extravascular space are selectively suppressed by combining flow-weighting with additional refocusing pulses. The results indicate two qualitatively different components of flowing blood which contribute to the BOLD contrast and a nearly equal share in functional signal from the intra- and extravascular compartments at TE approximately 80 ms and 3 T. Combining these results, there is evidence that at least one-half of the functional signal originates from the parenchyma in SE fMRI at 3 T. The authors suggest the use of flow-compensated diffusion weighting for SE fMRI to improve the sensitivity to the parenchyma.


Magn Reson Med


Jochimsen TH,Norris DG,Mildner T,Möller HE




Has Abstract


2004-10-01 00:00:00












  • Real-time observation of transient focal ischemia and hyperemia in cat brain.

    abstract::Gradient-recalled echo-planar (T2*-weighted) imaging was used to noninvasively monitor regional blood oxygenation state changes in real time during transient episodes of focal ischemia in cat brain. Varying ischemic intervals (12 s to 30 min) were caused by middle cerebral artery occlusion. A rapid signal drop was not...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: De Crespigny AJ,Wendland MF,Derugin N,Kozniewska E,Moseley ME

    更新日期:1992-10-01 00:00:00

  • Unambiguous assignment of the H3S and H3R deuterations of cerebral (2-13C) glutamate by 13C NMR at 18.8 Tesla.

    abstract::We used high-field (13)C NMR (18.8 T) to assign unambiguously the isotopic shifts induced by the deuterium substitutions of the H3(proR) and H3(proS) hydrogens of (2-(13)C) glutamate in extracts of the brain from deuterated animals. Monodeuterated H3R or H3S glutamate diastereoisomers were produced stereospecifically ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Rodrigues TB,Violante IR,Cerdán S

    更新日期:2010-04-01 00:00:00

  • Functional magnetic resonance imaging in real time (FIRE): sliding-window correlation analysis and reference-vector optimization.

    abstract::New algorithms for correlation analysis are presented that allow the mapping of brain activity from functional MRI (fMRI) data in real time during the ongoing scan. They combine the computation of the correlation coefficients between measured fMRI time-series data and a reference vector with "detrending", a technique ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Gembris D,Taylor JG,Schor S,Frings W,Suter D,Posse S

    更新日期:2000-02-01 00:00:00

  • Fast diffusion imaging with high angular resolution.

    abstract:PURPOSE:High angular resolution diffusion imaging (HARDI) is a well-established method to help reveal the architecture of nerve bundles, but long scan times and geometric distortions inherent to echo planar imaging (EPI) have limited its integration into clinical protocols. METHODS:A fast imaging method is proposed he...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Chao TC,Chiou JG,Maier SE,Madore B

    更新日期:2017-02-01 00:00:00

  • Fetal whole-heart 4D imaging using motion-corrected multi-planar real-time MRI.

    abstract:PURPOSE:To develop an MRI acquisition and reconstruction framework for volumetric cine visualization of the fetal heart and great vessels in the presence of maternal and fetal motion. METHODS:Four-dimensional (4D) depiction was achieved using a highly-accelerated multi-planar real-time balanced steady-state free prece...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: van Amerom JFP,Lloyd DFA,Deprez M,Price AN,Malik SJ,Pushparajah K,van Poppel MPM,Rutherford MA,Razavi R,Hajnal JV

    更新日期:2019-09-01 00:00:00

  • Low-rank plus sparse compressed sensing for accelerated proton resonance frequency shift MR temperature imaging.

    abstract:PURPOSE:To improve multichannel compressed sensing (CS) reconstruction for MR proton resonance frequency (PRF) shift thermography, with application to MRI-induced RF heating evaluation and MR guided high intensity focused ultrasound (MRgFUS) temperature monitoring. METHODS:A new compressed sensing reconstruction is pr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Cao Z,Gore JC,Grissom WA

    更新日期:2019-06-01 00:00:00

  • Mapping of redox status in a brain-disease mouse model by three-dimensional EPR imaging.

    abstract::Electron paramagnetic resonance imaging using nitroxides is a powerful method for visualizing the redox status modulated by oxidative stress in vivo. Typically, however, data acquisition times have been too slow to obtain a sufficient number of projections for three-dimensional images, when using continuous wave-elect...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Fujii H,Sato-Akaba H,Kawanishi K,Hirata H

    更新日期:2011-01-01 00:00:00

  • A 13C NMR study of the application of [U-13C]succinate for metabolic investigations in rabbit renal proximal convoluted tubular cells.

    abstract::The fate of the 13C label arising from [U-13C]succinate in rabbit renal proximal convoluted tubular (PCT) cells, incubated with [U-13C]succinate, was investigated by 13C NMR spectroscopy of the perchloric acid extracts of the cell pellets. The 13C label of [U-13C]succinate was predominantly metabolized into glutamate,...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Jans AW,Willem R

    更新日期:1990-04-01 00:00:00

  • Measurement of perfusion and permeability from dynamic contrast-enhanced MRI in normal and pathological vertebral bone marrow.

    abstract::Dynamic contrast-enhanced MRI data in vertebral bone marrow (vBM) are currently analyzed with descriptive indices. The purpose of this study was to develop and evaluate a quantitative approach, considering the tissue composition of vBM. Therefore, a measurement of the water fraction, f(wat), and the precontrast relaxa...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Biffar A,Sourbron S,Schmidt G,Ingrisch M,Dietrich O,Reiser MF,Baur-Melnyk A

    更新日期:2010-07-01 00:00:00

  • Constrained length minimum inductance gradient coil design.

    abstract::A gradient coil design algorithm capable of controlling the position of the homogeneous region of interest (ROI) with respect to the current-carrying wires is required for many advanced imaging and spectroscopy applications. A modified minimum inductance target field method that allows the placement of a set of constr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Chronik BA,Rutt BK

    更新日期:1998-02-01 00:00:00

  • Local specific absorption rate in brain tumors at 7 tesla.

    abstract:PURPOSE:MR safety at 7 Tesla relies on accurate numerical simulations of transmit electromagnetic fields to fully assess local specific absorption rate (SAR) safety. Numerical simulations for SAR safety are currently performed using models of healthy patients. These simulations might not be useful for estimating SAR in...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Restivo MC,van den Berg CA,van Lier AL,Polders DL,Raaijmakers AJ,Luijten PR,Hoogduin H

    更新日期:2016-01-01 00:00:00

  • Probing treatment response of glutaminolytic prostate cancer cells to natural drugs with hyperpolarized [5-(13) C]glutamine.

    abstract:PURPOSE:The correlation between glutamine metabolism and oncogene expression in cancers has led to a renewed interest in the role of glutamine in cancer cell survival. Hyperpolarized [5-(13) C]glutamine is evaluated as a potential biomarker for noninvasive metabolic measurements of drug response in prostate cancer cell...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Canapè C,Catanzaro G,Terreno E,Karlsson M,Lerche MH,Jensen PR

    更新日期:2015-06-01 00:00:00

  • Nuclear relaxation of human brain gray and white matter: analysis of field dependence and implications for MRI.

    abstract::The dependence of 1/T1 on the magnetic field strength (the relaxation dispersion) has been measured at 37 degrees C on autopsy samples of human brain gray and white matter at field strengths corresponding to proton Larmor frequencies between 10 kHz and 50 MHz (0.0002-1.2 T). Additional measurements of 1/T1 and 1/T2 ha...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Fischer HW,Rinck PA,Van Haverbeke Y,Muller RN

    更新日期:1990-11-01 00:00:00

  • Perfusion mapping with multiecho multishot parallel imaging EPI.

    abstract::Echo-planar imaging (EPI) is the standard technique for dynamic susceptibility-contrast (DSC) perfusion MRI. However, EPI suffers from well-known geometric distortions, which can be reduced by increasing the k-space phase velocity. Moreover, the long echo times (TEs) used in DSC lead to signal saturation of the arteri...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Newbould RD,Skare ST,Jochimsen TH,Alley MT,Moseley ME,Albers GW,Bammer R

    更新日期:2007-07-01 00:00:00

  • Three-dimensional cine imaging using variable-density spiral trajectories and SSFP with application to coronary artery angiography.

    abstract::A single breath-hold 3D cardiac phase resolved steady-state free precession (SSFP) sequence was developed, allowing 3D visualization of the moving coronary arteries. A 3D stack of spirals was acquired continuously throughout the cardiac cycle, and a sliding window reconstruction was used to achieve high temporal resol...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Kressler B,Spincemaille P,Nguyen TD,Cheng L,Xi Hai Z,Prince MR,Wang Y

    更新日期:2007-09-01 00:00:00

  • Evaluation of motion and realignment for functional magnetic resonance imaging in real time.

    abstract::Functional magnetic resonance imaging in real time is an emerging tool for the assessment of dynamic changes in brain activation. The short response latency (tens of seconds) renders the technique more sensitive to motion artifacts. Motion correction in real time requires computationally efficient algorithms which can...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Mathiak K,Posse S

    更新日期:2001-01-01 00:00:00

  • Direction-averaged diffusion-weighted MRI signal using different axisymmetric B-tensor encoding schemes.

    abstract:PURPOSE:It has been shown, theoretically and in vivo, that using the Stejskal-Tanner pulsed-gradient, or linear tensor encoding (LTE), and in tissue exhibiting a "stick-like" diffusion geometry, the direction-averaged diffusion-weighted MRI signal at high b-values ( ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Afzali M,Aja-Fernández S,Jones DK

    更新日期:2020-09-01 00:00:00

  • Passive tracking of catheters and guidewires by contrast-enhanced MR fluoroscopy.

    abstract::Passive MR tracking of catheters and guidewires is usually done by dynamically imaging a single thick slab, subtracting a baseline image, and combining the result with a previously acquired MR angiogram. In the in vitro and in vivo experiments reported here, it is demonstrated that this approach may be greatly simplif...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Bakker CJ,Bos C,Weinmann HJ

    更新日期:2001-01-01 00:00:00

  • An analytical solution for the SSFP signal in MRI.

    abstract::Among previous analyses of the steady-state free-precession (SSFP) signal in rapid MRI, one treatment resulted in equations that require the evaluation of infinite binomial series. Here, an analytical solution is derived by a transformation into the power series expansion of the derivative of the inverse sine function...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hänicke W,Vogel HU

    更新日期:2003-04-01 00:00:00

  • Quantifying the effect of dobutamine stress on myocardial Pi and pH in healthy volunteers: A 31 P MRS study at 7T.

    abstract:PURPOSE:Phosphorus spectroscopy (31 P-MRS) is a proven method to probe cardiac energetics. Studies typically report the phosphocreatine (PCr) to adenosine triphosphate (ATP) ratio. We focus on another 31 P signal: inorganic phosphate (Pi), whose chemical shift allows computation of myocardial pH, with Pi/PCr providing ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Apps A,Valkovič L,Peterzan M,Lau JYC,Hundertmark M,Clarke W,Tunnicliffe EM,Ellis J,Tyler DJ,Neubauer S,Rider OJ,Rodgers CT,Schmid AI

    更新日期:2021-03-01 00:00:00

  • Myocardial fat quantification in humans: Evaluation by two-point water-fat imaging and localized proton spectroscopy.

    abstract::Proton MR spectroscopy ((1)H-MRS) has been used for in vivo quantification of intracellular triglycerides within the sarcolemma. The purpose of this study was to assess whether breath-hold dual-echo in- and out-of-phase MRI at 3.0 T can quantify the fat content of the myocardium. Biases, including T(1), T*(2), and noi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Liu CY,Redheuil A,Ouwerkerk R,Lima JA,Bluemke DA

    更新日期:2010-04-01 00:00:00

  • Dysprosium-bearing red cells as potential transverse relaxation agents for MRI.

    abstract::The cytosol of intact human red blood cells was loaded with 28.1 +/- 3.4 mM of dysprosium DTPA-BMA using a hypoosmotic technique. When loaded cells were diluted with saline and control cells to give an average dysprosium concentration of 3.3 +/- 0.5 mM, the transverse relaxation rate constants R(*)(2) and R(2) increas...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Johnson KM,Tao JZ,Kennan RP,Gore JC

    更新日期:2001-05-01 00:00:00

  • Impact of capped and uncapped abandoned leads on the heating of an MR-conditional pacemaker implant.

    abstract:PURPOSE:To assess the risk of radiofrequency (RF)-induced heating in patients with MR-conditional pacemaker (PM) systems, in the presence of another lead abandoned from a previous implant. METHODS:Four commercial pacemaker leads were placed beside a MR-conditional PM system, inside a human trunk simulator. The phantom...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Mattei E,Gentili G,Censi F,Triventi M,Calcagnini G

    更新日期:2015-01-01 00:00:00

  • Echo-time reduction for submillimeter resolution imaging with a 3D phase encode time reduced acquisition method.

    abstract::To achieve optimal image quality and highest spatial resolution for inner ear imaging with a 3D gradient echo sequence, it is necessary to minimize susceptibility dephasing effects by using very short TE. Fractional RF pulses and echoes can yield short TE for moderate spatial resolution; however, for voxel size of les...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Ying K,Schmalbrock P,Clymer B

    更新日期:1995-01-01 00:00:00

  • Lactate isotopomer analysis by 1H NMR spectroscopy: consideration of long-range nuclear spin-spin interactions.

    abstract::Lactate is a key metabolite and its rates of cellular uptake and release, its production rates from glucose and glycogen, and its interconversion rate with pyruvate are important determinants of cellular energy production. If lactate precursors such as pyruvate and glucose are labeled appropriately with (13)C, (1)H NM...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Lloyd SG,Zeng H,Wang P,Chatham JC

    更新日期:2004-06-01 00:00:00

  • MRI: the development of T2 contrast with rapid field echo sequences.

    abstract::The soft tissue contrast obtained in fast imaging using rapidly repeated partial saturation sequences is usually based on differences in T1. We describe here an extension of the method which results in the development of clinically useful T2-based contrast. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Young IR,Payne JA,Collins AG,Bydder GM

    更新日期:1987-04-01 00:00:00

  • The sensitivity of low flip angle RARE imaging.

    abstract::It is demonstrated that the stability of the Carr-Purcell-Meiboom-Gill (CPMG) sequence reflects the existence of a steady state solution to the Bloch equations in the absence of T2 and T1 decay. The steady state theory is then used to evaluate the performance of low flip angle RARE imaging sequences with both constant...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Alsop DC

    更新日期:1997-02-01 00:00:00

  • Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1-13 C]pyruvate and 13 C-urea.

    abstract:PURPOSE:To demonstrate the feasibility of imaging a bolus of co-polarized [1-13 C]pyruvate and 13 C-urea to simultaneously assess both metabolism and perfusion in the rodent heart. METHODS:Copolarized [1-13 C]pyruvate and 13 C-urea was imaged using a multi-echo, flow-sensitized spiral pulse sequence. Healthy rats were...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Lau AZ,Miller JJ,Robson MD,Tyler DJ

    更新日期:2017-01-01 00:00:00

  • Conversion of arterial input functions for dual pharmacokinetic modeling using Gd-DTPA/MRI and 18F-FDG/PET.

    abstract::Reaching the full potential of magnetic resonance imaging (MRI)-positron emission tomography (PET) dual modality systems requires new methodologies in quantitative image analyses. In this study, methods are proposed to convert an arterial input function (AIF) derived from gadolinium-diethylenetriaminepentaacetic acid ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Poulin E,Lebel R,Croteau E,Blanchette M,Tremblay L,Lecomte R,Bentourkia M,Lepage M

    更新日期:2013-03-01 00:00:00

  • Simple measurement of scanner stability for functional NMR imaging of activation in the brain.

    abstract::Functional MR imaging (fMRI) of activation in the brain is one of the more demanding applications required of an NMR imaging instrument. Since the signal changes in activation imaging are quite small, any instrumental variations can easily compromise the fMRI contrast. The authors describe a simple method for measurin...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Weisskoff RM

    更新日期:1996-10-01 00:00:00