In vivo measurements of bone marrow cellularity using volume-localized proton NMR spectroscopy.

Abstract:

:Volume-localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24-h period before or after the NMR exam. The results obtained by the two methods are well correlated (R = 0.94, P less than 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases.

journal_name

Magn Reson Med

authors

Ballon D,Jakubowski A,Gabrilove J,Graham MC,Zakowski M,Sheridan C,Koutcher JA

doi

10.1002/mrm.1910190108

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

85-95

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

19

pub_type

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