Abstract:
PURPOSE:To develop the simultaneous acquisition of multiple voxels in localized MR spectroscopy (MRS) using sensitivity encoding, allowing reduced total scan time compared to conventional sequential single voxel (SV) acquisition methods. METHODS:Dual volume localization was used to simultaneously excite voxels in both hemispheres. Receiver coil sensitivity profiles were used to unfold the data. To demonstrate the method, MRS voxels in the left and right hippocampus were measured at 3 tesla (T) and the left and right motor cortices at 7T. Spectra were compared to conventional SV acquisitions. Spectra were also recorded from the lesion and contralateral hemisphere of a patient with a low-grade oligodendroglioma at 7T. RESULTS:It was possible to generate signal in two voxels simultaneously and separate the signal originating from the different locations, with spectral results almost identical to those observed using conventional single voxel methods. The method results in an increased chemical shift displacement artifact, which might be improved by advanced pulse designs, and a noise increase due to the unfolding g-factor, which was larger at 3T than 7T. CONCLUSION:The simultaneous acquisition of voxels for MRS is possible by using modulated slice-selective pulses and receive coil sensitivity profiles to unfold the resulting signals.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Boer VO,Klomp DW,Laterra J,Barker PBdoi
10.1002/mrm.25718subject
Has Abstractpub_date
2015-09-01 00:00:00pages
599-606issue
3eissn
0740-3194issn
1522-2594journal_volume
74pub_type
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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