High-resolution 1H NMR spectroscopy in rat liver using magic angle turning at a 1 Hz spinning rate.

Abstract:

:It is demonstrated that a high-resolution (1)H NMR spectrum of excised rat liver can be obtained using the technique of magic angle turning (MAT) at a sample spinning rate of 1 Hz. A variant of the phase-corrected MAT (PHORMAT) pulse sequence that includes a water suppression segment was developed for the investigation. The spectral resolution achieved with PHORMAT approaches that obtained from a standard magic angle spinning (MAS) experiment at a spinning rate of several kHz. With such ultra-slow spinning, tissue and cell damage associated with the standard MAS experiment is minimized or eliminated. The technique is potentially useful for obtaining high-resolution (1)H spectra in live animals.

journal_name

Magn Reson Med

authors

Hu JZ,Rommereim DN,Wind RA

doi

10.1002/mrm.10139

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

829-36

issue

5

eissn

0740-3194

issn

1522-2594

journal_volume

47

pub_type

杂志文章
  • Accelerated J-resolved 1 H-MRSI with limited and sparse sampling of ( k , t 1 , t 2 -space.

    abstract:PURPOSE:To accelerate the acquisition of J-resolved proton magnetic resonance spectroscopic imaging (1 H-MRSI) data for high-resolution mapping of brain metabolites and neurotransmitters. METHODS:The proposed method used a subspace model to represent multidimensional spatiospectral functions, which significantly reduc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28413

    authors: Tang L,Zhao Y,Li Y,Guo R,Clifford B,El Fakhri G,Ma C,Liang ZP,Luo J

    更新日期:2021-01-01 00:00:00

  • Sensitivity of MR diffusion measurements to variations in intracellular structure: effects of nuclear size.

    abstract::Magnetic resonance imaging measurements of the apparent rate of water diffusion in tumors are sensitive to variations in tissue cellularity, which have been shown useful for characterizing tumors and their responses to treatments. However, because of technical limitations on most MRI systems, conventional pulse gradie...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21793

    authors: Xu J,Does MD,Gore JC

    更新日期:2009-04-01 00:00:00

  • Imaging articular cartilage under compression--cartilage elastography.

    abstract::We constructed a device to compress small samples of articular cartilage while the samples were imaged in a 1.5 T imager. With the use of a piezoelectric piston, the device compressed 1-cm-diameter cylindrical samples of articular cartilage (200 microm) at a rate of 2 Hz. Simultaneously, we imaged the samples with a d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20439

    authors: Hardy PA,Ridler AC,Chiarot CB,Plewes DB,Henkelman RM

    更新日期:2005-05-01 00:00:00

  • A double echo ultra short echo time (UTE) acquisition for respiratory motion-suppressed high resolution imaging of the lung.

    abstract:PURPOSE:Magnetic resonance imaging is a promising alternative to computed tomography for lung imaging. However, organ motion and poor signal-to-noise ratio, arising from short T2*, impair image quality. To alleviate these issues, a new retrospective gating method was implemented and tested with an ultra-short echo time...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26891

    authors: Delacoste J,Chaptinel J,Beigelman-Aubry C,Piccini D,Sauty A,Stuber M

    更新日期:2018-04-01 00:00:00

  • B factor dependence of the temporal characteristics of brain activation using dynamic apparent diffusion coefficient contrast.

    abstract::Functional MRI studies to date have been generally performed using the blood oxygenation level dependent (BOLD) contrast mechanism. Recently, it has been proposed that dynamic change in the apparent diffusion coefficient (ADC), measured using intravoxel incoherent motion (IVIM) weighting, can be used as a robust funct...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20293

    authors: Harshbarger TB,Song AW

    更新日期:2004-12-01 00:00:00

  • Hyperpolarized 13C MRI of the pulmonary vasculature and parenchyma.

    abstract::The study of lung perfusion in normal and diseased subjects is of great interest to physiologists and physicians. In this work we demonstrate the application of a liquid-phase hyperpolarized (HP) carbon-13 ((13)C) tracer to magnetic resonance imaging (MRI) of the pulmonary vasculature and pulmonary perfusion in a porc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21168

    authors: Ishii M,Emami K,Kadlecek S,Petersson JS,Golman K,Vahdat V,Yu J,Cadman RV,MacDuffie-Woodburn J,Stephen M,Lipson DA,Rizi RR

    更新日期:2007-03-01 00:00:00

  • Regularized higher-order in vivo shimming.

    abstract::A regularized algorithm is presented for localized in vivo shimming. The technique uses first- (X,Y,Z), second- (Z(2), ZX, ZY, X(2)-Y(2), XY), and third-order (Z(3)) shim coils, and is robust when applied to arbitrarily-shaped, as well as off-center, regions of interest (ROIs). A single-shot spiral pulse sequence is u...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10267

    authors: Kim DH,Adalsteinsson E,Glover GH,Spielman DM

    更新日期:2002-10-01 00:00:00

  • Three-dimensional water/fat separation and T2* estimation based on whole-image optimization--application in breathhold liver imaging at 1.5 T.

    abstract::The chemical shift of water and fat resonances in proton MRI allows separation of water and fat signal from chemical shift encoded data. This work describes an automatic method that produces separate water and fat images as well as quantitative maps of fat signal fraction and T2* from complex multiecho gradient-recall...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23185

    authors: Berglund J,Kullberg J

    更新日期:2012-06-01 00:00:00

  • Positive contrast visualization of iron oxide-labeled stem cells using inversion-recovery with ON-resonant water suppression (IRON).

    abstract::In proton magnetic resonance imaging (MRI) metallic substances lead to magnetic field distortions that often result in signal voids in the adjacent anatomic structures. Thus, metallic objects and superparamagnetic iron oxide (SPIO)-labeled cells appear as hypointense artifacts that obscure the underlying anatomy. The ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21399

    authors: Stuber M,Gilson WD,Schär M,Kedziorek DA,Hofmann LV,Shah S,Vonken EJ,Bulte JW,Kraitchman DL

    更新日期:2007-11-01 00:00:00

  • Editing through multiple bonds: threonine detection.

    abstract::In in vivo (1)H spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of either threonine or lactate without and even with editing technical...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21492

    authors: Marjanska M,Henry PG,Uğurbil K,Gruetter R

    更新日期:2008-02-01 00:00:00

  • Dynamic field map estimation using a spiral-in/spiral-out acquisition.

    abstract::The long readout times of single-shot acquisitions and the high field strengths desired for functional MRI (fMRI) using blood oxygenation level-dependent (BOLD) contrast make functional scans sensitive to magnetic field inhomogeneity. If it is not corrected during image reconstruction, field inhomogeneity can cause ge...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20079

    authors: Sutton BP,Noll DC,Fessler JA

    更新日期:2004-06-01 00:00:00

  • Total removal of unwanted harmonic peaks (TruHARP) MRI for single breath-hold high-resolution myocardial motion and strain quantification.

    abstract::Current MRI methods for myocardial motion and strain quantification have limited resolution because of Fourier space spectral peak interference. Methods have been proposed to remove this interference in order to improve resolution; however, these methods are clinically impractical due to the prolonged imaging times. I...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22403

    authors: Agarwal HK,Prince JL,Abd-Elmoniem KZ

    更新日期:2010-08-01 00:00:00

  • Cerebral T1rho relaxation time increases immediately upon global ischemia in the rat independently of blood glucose and anoxic depolarization.

    abstract::Time-dependent changes of T1 in the rotating frame (T1rho), diffusion, T2, and magnetization transfer contrast on cardiac arrest-induced global ischemia in rat were investigated. T1rho, as acquired with spin lock amplitudes >0.6 G, started to increase 10-20 sec after cardiac arrest followed by an increase within 3-4 m...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1228

    authors: Kettunen MI,Gröhn OH,Penttonen M,Kauppinen RA

    更新日期:2001-09-01 00:00:00

  • Echo time-dependent quantitative susceptibility mapping contains information on tissue properties.

    abstract:PURPOSE:Magnetic susceptibility is a physical property of matter that varies depending on chemical composition and abundance of different molecular species. Interest is growing in mapping of magnetic susceptibility in the human brain using magnetic resonance imaging techniques, but the influences affecting the mapped v...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26281

    authors: Sood S,Urriola J,Reutens D,O'Brien K,Bollmann S,Barth M,Vegh V

    更新日期:2017-05-01 00:00:00

  • Dynamic per slice shimming for simultaneous brain and spinal cord fMRI.

    abstract:PURPOSE:Simultaneous brain and spinal cord functional MRI is emerging as a new tool to study the central nervous system but is challenging. Poor B0 homogeneity and small size of the spinal cord are principal obstacles to this nascent technology. Here we extend a dynamic shimming approach, first posed by Finsterbusch, b...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27388

    authors: Islam H,Law CSW,Weber KA,Mackey SC,Glover GH

    更新日期:2019-02-01 00:00:00

  • Quantitative transport mapping (QTM) of the kidney with an approximate microvascular network.

    abstract:PURPOSE:Proof-of-concept study of mapping renal blood flow vector field according to the inverse solution to a mass transport model of time resolved tracer-labeled MRI data. THEORY AND METHODS:To determine tissue perfusion according to the underlying physics of spatiotemporal tracer concentration variation, the mass t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28584

    authors: Zhou L,Zhang Q,Spincemaille P,Nguyen TD,Morgan J,Dai W,Li Y,Gupta A,Prince MR,Wang Y

    更新日期:2021-04-01 00:00:00

  • Application of DENSE-MR-elastography to the human heart.

    abstract::Typically, MR-elastography (MRE) encodes the propagation of monochromatic acoustic waves in the MR-phase images via sinusoidal gradients characterized by a detection frequency equal to the frequency of the mechanical vibration. Therefore, the echo time of a conventional MRE sequence is typically longer than the vibrat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22124

    authors: Robert B,Sinkus R,Gennisson JL,Fink M

    更新日期:2009-11-01 00:00:00

  • Skeletal muscle ¹H MRSI before and after prolonged exercise. I. muscle specific depletion of intramyocellular lipids.

    abstract::Aim of the study was to determine distribution and depletion patterns of intramyocellular lipids (IMCL) in leg muscles before and after two types of standardized endurance exercise. ¹H-magnetic resonance spectroscopic imaging was performed (1) in the thigh of eight-trained cyclists after exercising on an ergometer for...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/mrm.24168

    authors: Vermathen P,Saillen P,Boss A,Zehnder M,Boesch C

    更新日期:2012-11-01 00:00:00

  • Theoretical model of the single spin-echo relaxation time for spherical magnetic perturbers.

    abstract:PURPOSE:Magnetically labeled cells and tissue iron deposits provide qualitative means to detect and monitor cardiovascular and cerebrovascular diseases with magnetic resonance imaging. However, to quantitatively examine the extent of pathological micromorphological changes, detailed knowledge about microstructural para...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25196

    authors: Kurz FT,Kampf T,Heiland S,Bendszus M,Schlemmer HP,Ziener CH

    更新日期:2014-05-01 00:00:00

  • Multidimensionally encoded magnetic resonance imaging.

    abstract::Magnetic resonance imaging (MRI) typically achieves spatial encoding by measuring the projection of a q-dimensional object over q-dimensional spatial bases created by linear spatial encoding magnetic fields (SEMs). Recently, imaging strategies using nonlinear SEMs have demonstrated potential advantages for reconstruct...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24443

    authors: Lin FH

    更新日期:2013-07-01 00:00:00

  • T1 rho relaxation and its application to MR histology.

    abstract::The application of T1 rho an an alternative contrast parameter in high-field magnetic resonance histology (MRH) has been investigated. Spectroscopic measurements of T1 rho were performed on 5.75% agar and 1.0 mM MnCI2 phantoms at 9.4 T to validate the accuracy of the imaging measurements. Image studies were performed ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910350520

    authors: Engelhardt RT,Johnson GA

    更新日期:1996-05-01 00:00:00

  • Determination of the optimal first-order gradient moment for flow-sensitive dephasing magnetization-prepared 3D noncontrast MR angiography.

    abstract::Flow-sensitive dephasing (FSD) magnetization preparation has been developed for black-blood vessel wall MRI and noncontrast MR angiography. The first-order gradient moment, m(1) , is a measure of the flow-sensitization imparted by an FSD preparative module. Determination of the optimal m(1) for each individual is high...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22847

    authors: Fan Z,Zhou X,Bi X,Dharmakumar R,Carr JC,Li D

    更新日期:2011-04-01 00:00:00

  • Improved steering of the RF field of traveling wave MR with a multimode, coaxial waveguide.

    abstract:PURPOSE:Magnetic resonance imaging of humans at high magnetic field strengths is strongly influenced by the interference of the radiofrequency (RF) electromagnetic field and the body. To minimize this effect, multiple RF sources could be used. A novel setup (called multimode, coaxial waveguide) is proposed that facilit...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24807

    authors: Andreychenko A,Kroeze H,Boer VO,Lagendijk JJ,Luijten PR,van den Berg CA

    更新日期:2014-04-01 00:00:00

  • Quantitative measurement of regional lung ventilation using 3He MRI.

    abstract::A new strategy for a quantitative measurement of regional pulmonary ventilation using hyperpolarized helium-3 (3He) MRI has been developed. The method employs the build-up of the signal intensity after a variable number of (3)He breaths. A mathematical model of the signal dynamics is presented, from which the local ve...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10206

    authors: Deninger AJ,Månsson S,Petersson JS,Pettersson G,Magnusson P,Svensson J,Fridlund B,Hansson G,Erjefeldt I,Wollmer P,Golman K

    更新日期:2002-08-01 00:00:00

  • Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes.

    abstract::Using NMR spectroscopy, we studied purified, human T lymphocytes in a serum-free medium. Purified cells were entrapped inside agarose beads and induced to proliferate by the mitogens phorbol-12-myristate-13-acetate and ionomycin. T lymphocytes in standard culture and inside agarose beads exhibit comparable viability, ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290307

    authors: Bental M,Deutsch C

    更新日期:1993-03-01 00:00:00

  • Spectroscopic imaging of glutamate C4 turnover in human brain.

    abstract::One-dimensional spectroscopic imaging of (13)C-4-glutamate turnover is performed in the human brain with a 6 cc nominal voxel resolution at 4T. Data were acquired with an indirect detection approach using a short spin echo single quantum (1)H-(13)C heteronuclear editing method and a 7 cm surface coil with quadrature (...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200011)44:5<673::aid-mrm3>3.0.co

    authors: Pan JW,Stein DT,Telang F,Lee JH,Shen J,Brown P,Cline G,Mason GF,Shulman GI,Rothman DL,Hetherington HP

    更新日期:2000-11-01 00:00:00

  • Free breathing three-dimensional late gadolinium enhancement cardiovascular magnetic resonance using outer volume suppressed projection navigators.

    abstract:PURPOSE:To develop a three-dimensional, free-breathing, late gadolinium enhancement (3D FB-LGE) cardiovascular magnetic resonance (CMR) technique, and to compare it with clinically used two-dimensional breath-hold LGE (2D BH-LGE). METHODS:The proposed 3D FB-LGE method consisted of inversion preparation, inversion dela...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26234

    authors: Menon RG,Miller GW,Jeudy J,Rajagopalan S,Shin T

    更新日期:2017-04-01 00:00:00

  • Value of a blood pool contrast agent in MR venography of the lower extremities and pelvis: preliminary results in 12 patients.

    abstract::The purpose of this study was to determine the value of a blood-pool contrast media (NC100150, Nycomed Imaging (now Amersham Health) Oslo, Norway) for evaluation of venous thrombosis of the deep veins of the pelvis and lower extremities. Twelve patients were prospectively evaluated with conventional X-ray venography (...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/mrm.10607

    authors: Aschauer M,Deutschmann HA,Stollberger R,Hausegger KA,Obernosterer A,Schöllnast H,Ebner F

    更新日期:2003-11-01 00:00:00

  • Correction of motion-induced susceptibility artifacts and B0 drift during proton resonance frequency shift-based MR thermometry in the pelvis with background field removal methods.

    abstract:PURPOSE:The linear change of the water proton resonance frequency shift (PRFS) with temperature is used to monitor temperature change based on the temporal difference of image phase. Here, the effect of motion-induced susceptibility artifacts on the phase difference was studied in the context of mild radio frequency hy...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28302

    authors: Wu M,Mulder HT,Baron P,Coello E,Menzel MI,van Rhoon GC,Haase A

    更新日期:2020-11-01 00:00:00

  • Metabolite and macromolecule T1 and T2 relaxation times in the rat brain in vivo at 17.2T.

    abstract:PURPOSE:To measure the T1 and T2 relaxation times of water, metabolites, and macromolecules in the rat brain in vivo at 17.2T and achieve absolute quantification of the neurochemical profile. Relaxation times were compared with values from the literature found at lower magnetic fields. METHODS:(1) H NMR spectra were m...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25602

    authors: Lopez-Kolkovsky AL,Mériaux S,Boumezbeur F

    更新日期:2016-02-01 00:00:00