Abstract:
:Direct measurement of neural currents by means of MRI can potentially open a high temporal resolution (10-100 ms) window applicable for monitoring dynamics of neuronal activity without loss of the high spatial resolution afforded by MRI. Previously, we have shown that the alternating balanced steady state imaging affords high sensitivity to weak periodic currents owing to its amplification of periodic spin phase perturbations. This technique, however, requires precise synchronization of such perturbations to the radiofrequency pulses. Herein, we extend alternating balanced steady state imaging to multiple balanced alternating steady states for estimation of neural current waveforms. Simulations and phantom experiments show that the off-resonance profile of the multiple alternating steady state signal carries information about the frequency content of driving waveforms. In addition, the method is less sensitive than alternating balanced steady state to precise waveform timing relative to radiofrequency pulses. Thus, multiple alternating steady state technique is potentially applicable to MR imaging of the waveforms of periodic neuronal activity.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Buračas GT,Jung Y,Lee J,Buxton RB,Wong EC,Liu TTdoi
10.1002/mrm.23105subject
Has Abstractpub_date
2012-05-01 00:00:00pages
1412-8issue
5eissn
0740-3194issn
1522-2594journal_volume
67pub_type
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