Altered white matter diffusion anisotropy in normal and preterm infants at term-equivalent age.

Abstract:

:To investigate white matter (WM) development, voxelwise analyses of diffusion tensor MRI (DTMRI) data, acquired from 12 very preterm and 11 preterm infants with gestational ages (GA) ranging from 25 to 29 and 29 to 32 weeks, respectively, and 10 newborn normal term infants were performed. T(2) relaxation measures were also generated to assess brain water content. Compared with newborn term infants, very preterm infants were found to possess reduced fractional anisotropy (FA) within the frontal lobe, and a number of anterior and posterior commissural pathways. Preterm infants possessed reduced FA mainly within the posterior regions of the corpus callosum. Unexpectedly, we observed significantly reduced FA and increased T(2) within a number of corticospinal projections in the newborn term infants compared to the preterm groups. This finding may reflect increased water concentration and/or a lowering of FA due to the presence of crossing interhemispheric WM projections. These findings indicate that care should be taken when interpreting FA indices without knowledge of the possible effects of water concentration in the newborn infant brain.

journal_name

Magn Reson Med

authors

Rose SE,Hatzigeorgiou X,Strudwick MW,Durbridge G,Davies PS,Colditz PB

doi

10.1002/mrm.21689

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

761-7

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

60

pub_type

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