2H double quantum filtered (DQF) NMR spectroscopy of the nucleus pulposus tissues of the intervertebral disc.

Abstract:

:Deuterium (2H) double-quantum filtered (DQF) NMR spectroscopy of nucleus pulposus (NP) tissues from human intervertebral discs is reported. The DQF spectral intensities, DQ build-up rates, and DQF-detected rotating-frame spin-lattice relaxation times are sensitive to the degree of hydration of the NP tissue, and display a monotonous correlation with age between 15 and 80 years. The implications of this work are that the changes in water dynamics as detected via DQF NMR spectroscopy may be used as a probe of tissue degeneration in NP, particularly in the early stages of degeneration to which most standard NMR methods are not sensitive.

journal_name

Magn Reson Med

authors

Perea W,Cannella M,Yang J,Vega AJ,Polenova T,Marcolongo M

doi

10.1002/mrm.21231

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

990-9

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

57

pub_type

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