Abstract:
PURPOSE:To achieve rapid, high resolution whole-brain gray matter (GM) imaging by developing a novel, single-slab three-dimensional dual-echo fast-spin-echo pulse sequence and GM-selective reconstruction. METHODS:Unlike conventional GM imaging that uses time-consuming double-inversion-recovery preparation, the proposed pulse sequence was designed to have two split portions along the echo train, in which the first half was dedicated to yield short inversion recovery (IR)-induced white matter suppression and variable-flip-angle-induced two-step GM signal evolution while the second half cerebrospinal fluid-only signals. Multi-step variable-flip-angle schedules and sampling reordering were optimized to yield high GM signals while balancing cerebrospinal fluid signals between ECHOes. GM-selective images were then reconstructed directly from the weighted subtraction between ECHOes by solving a sparse signal recovery problem. In vivo studies were performed to validate the effectiveness of the proposed method over conventional double-inversion-recovery. RESULTS:The proposed method, while achieving one millimeter isotropic, whole-brain GM imaging within 5.5 min, showed superior performance than conventional double-inversion-recovery in producing GM-only images without apparent artifacts and noise. CONCLUSION:We successfully demonstrated the feasibility of the proposed method in achieving whole-brain GM imaging in a clinically acceptable imaging time. The proposed method is expected to be a promising alternative to conventional double-inversion-recovery in clinical applications. Magn Reson Med 78:1691-1699, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Lee H,Kim EY,Sohn CH,Park Jdoi
10.1002/mrm.26910subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1691-1699issue
5eissn
0740-3194issn
1522-2594journal_volume
78pub_type
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