Measurements of human cerebral GABA at 4.1 T using numerically optimized editing pulses.

Abstract:

:The goal of this work was to develop and evaluate a numerically optimized inversion pulse to be used with a homonuclear editing sequence to measure human cerebral GABA in vivo at 4.1 T in the occipital lobe. The optimized pulse was constructed using pallindromic symmetry with 30 pulses and 29 delays. The optimized pulse provided greater selectivity than the equivalent bandwidth matched DANTE pulse and sinc shaped DANTE. The improved selectivity reduced the co-editing of the macromolecule resonance, permitting the GABA edited doublet to be resolved in vivo. Using cerebral creatine as a reference, 7.1 mM, the measured GABA level was 1.15 +/- 0.13 mM in the occipital lobe.

journal_name

Magn Reson Med

authors

Hetherington HP,Newcomer BR,Pan JW

doi

10.1002/mrm.1910390103

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

6-10

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

39

pub_type

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