Abstract:
:The goal of this work was to develop and evaluate a numerically optimized inversion pulse to be used with a homonuclear editing sequence to measure human cerebral GABA in vivo at 4.1 T in the occipital lobe. The optimized pulse was constructed using pallindromic symmetry with 30 pulses and 29 delays. The optimized pulse provided greater selectivity than the equivalent bandwidth matched DANTE pulse and sinc shaped DANTE. The improved selectivity reduced the co-editing of the macromolecule resonance, permitting the GABA edited doublet to be resolved in vivo. Using cerebral creatine as a reference, 7.1 mM, the measured GABA level was 1.15 +/- 0.13 mM in the occipital lobe.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Hetherington HP,Newcomer BR,Pan JWdoi
10.1002/mrm.1910390103subject
Has Abstractpub_date
1998-01-01 00:00:00pages
6-10issue
1eissn
0740-3194issn
1522-2594journal_volume
39pub_type
杂志文章abstract:PURPOSE:To accelerate the acquisition of J-resolved proton magnetic resonance spectroscopic imaging (1 H-MRSI) data for high-resolution mapping of brain metabolites and neurotransmitters. METHODS:The proposed method used a subspace model to represent multidimensional spatiospectral functions, which significantly reduc...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28413
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abstract::It is shown that in vivo measurement of bile water apparent diffusion coefficient (ADC) by diffusion-weighted echo-planar imaging (EPI) in hamster gallbladder is possible providing motion artifact-free ADC values. These ADC values are used to estimate bile viscosity variation induced by normal diets, cholesterol galls...
journal_title:Magnetic resonance in medicine
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doi:10.1002/1522-2594(200006)43:6<854::aid-mrm11>3.0.c
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abstract::A study was made of the in vivo detectability of a pH-sensitive, imidazolidine spin probe, and the efficacy of low-frequency electron spin resonance (ESR)-based techniques for pH measurement in vitro and in vivo in rats. The techniques used were longitudinally-detected ESR (LODESR) and field-cycled dynamic nuclear pol...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.10392
更新日期:2003-03-01 00:00:00
abstract:PURPOSE:To present a new method that can simultaneously and efficiently measure T1 and B1 (+) maps using reference region variable flip angle (RR-VFA) imaging. METHODS:Assuming T1 relaxation time in a reference region such as fat is well characterized, and the reference region sufficiently covers smoothly varying B1 (...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24904
更新日期:2013-10-01 00:00:00
abstract::Intraplaque hemorrhage in atherosclerotic plaques has been associated with accelerated plaque growth as well as exacerbation of clinical symptoms. The identification of intraplaque hemorrhage using magnetic resonance imaging primarily relies on the detection of methemoglobin on T(1) weighted images. Current techniques...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22539
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:To analyze the effect of B0 field drift on multivoxel MR spectroscopic imaging and to propose an approach for its correction. THEORY AND METHODS:It is shown, both theoretically and in a phantom, that for ∼30 min acquisitions a linear B0 drift (∼0.1 ppm/h) will cause localization errors that can reach several v...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24536
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abstract:PURPOSE:To investigate the feasibility of estimating calibration constants (K and T2o ) in vivo for converting whole-blood T2 to blood hemoglobin oxygen saturation (HbO2 ) according to the Luz-Meiboom model, 1/T2=1/T2o+K(1-HbO2)2, where K and T2o are relaxivity and transverse relaxation time of fully saturated blood, r...
journal_title:Magnetic resonance in medicine
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abstract::A reproducibility study of proton MR spectroscopic imaging ((1)H-MRSI) of the human brain was conducted to evaluate the reliability of an automated 3D in vivo spectroscopic imaging acquisition and associated quantification algorithm. A PRESS-based pulse sequence was implemented using dualband spectral-spatial RF pulse...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21713
更新日期:2008-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.28321
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To measure the T1 and T2 relaxation times of water, metabolites, and macromolecules in the rat brain in vivo at 17.2T and achieve absolute quantification of the neurochemical profile. Relaxation times were compared with values from the literature found at lower magnetic fields. METHODS:(1) H NMR spectra were m...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25602
更新日期:2016-02-01 00:00:00
abstract::TSENSE and TGRAPPA are autocalibrated parallel imaging techniques that can improve the temporal resolution and/or spatial resolution in dynamic magnetic resonance imaging applications. In its original form, TSENSE uses temporal low-pass filtering of the undersampled frames to create the sensitivity map. TGRAPPA uses a...
journal_title:Magnetic resonance in medicine
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更新日期:2011-06-01 00:00:00
abstract::An implementation is reported of an imaging method to obtain MUltiple Resolutions along Phase-encode and Slice-select dimensions (MURPS), which enables dynamic imaging of focal changes using a graded, multiresolution approach. MURPS allows one to trade spatial resolution in part of the volume for improved temporal res...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1126
更新日期:2001-06-01 00:00:00
abstract::Quantification of localized in vivo brain 1H spectra is in general very difficult due to excessive spectral overlap. In addition, intensity distortions may result from the effects of the NMR pulse sequence on the spins. This paper describes an approach to solving these problems. It comprises optimization of the pulse ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910150212
更新日期:1990-08-01 00:00:00
abstract::Spiral k-space magnetic resonance spectroscopic imaging (MRSI) requires high performance from gradient hardware systems. During the readout phase, oscillating gradients are continuously played out, which can cause undesired effects. These effects on the quality of SI data are non-intuitive because of their time-varyin...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20928
更新日期:2006-07-01 00:00:00
abstract::Magnetization transfer experiments using an off-resonance irradiation technique were performed on bovine serum albumin solutions by varying the irradiation frequency and the concentration. A transition of the magnetization transfer spectrum from Lorentzian to Gaussian line shape was observed around the critical concen...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910320406
更新日期:1994-10-01 00:00:00
abstract::Parallel transmission has emerged as an efficient means for implementing multidimensional spatially selective radiofrequency excitation pulses. To date, most theoretical and experimental work on parallel transmission radiofrequency (RF) pulse design is based on the small-tip-angle approximation to the Bloch equation. ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.22827
更新日期:2011-09-01 00:00:00
abstract::A method for evaluating the sensitivity of MRI protocols to changes in an arbitrary number of tissue parameters over a broad range of parameter values is presented. This analysis is useful for choosing an optimal basis set of images for either a "survey" protocol or tissue segmentation algorithms. A survey protocol is...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910130202
更新日期:1990-02-01 00:00:00
abstract:PURPOSE:To investigate for the first time the feasibility of aortic four-dimensional (4D) flow at 7T, both contrast enhanced (CE) and non-CE. To quantify the signal-to-noise ratio (SNR) in aortic 4D flow as a function of field strength and CE with gadobenate dimeglumine (MultiHance). METHODS:Six healthy male volunteer...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25317
更新日期:2015-05-01 00:00:00
abstract::To investigate the dependency of T(1) relaxation on mechanical strain in articular cartilage, quantitative magnetic resonance T(1) imaging experiments were carried out on cartilage before/after the tissue was immersed in gadolinium contrast agent and when the tissue was being compressed (up to ∼ 48% strains). The spat...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.22933
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To compare the performance of an 8-channel surface coil/clamshell transmitter and 32-channel head array coil/birdcage transmitter for hyperpolarized 13 C brain metabolic imaging. METHODS:To determine the field homogeneity of the radiofrequency transmitters, B1 + mapping was performed on an ethylene glycol head...
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21683
更新日期:2008-10-01 00:00:00
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更新日期:2011-12-01 00:00:00
abstract::31P NMR of superfused resting cartilage demonstrated the presence of phosphocreatine in chondrocytes. Changes in pH and in the NTP level were followed during carbon source starvation. From 31P spectra of perchloric acid extracts, phosphoethanolamine, phosphocholine, and the corresponding glycerol diesters were identif...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910250215
更新日期:1992-06-01 00:00:00
abstract::Follow-up T(1)-weighted 3D gradient-echo MRI (2.35 T) of murine brain in vivo (N = 5) at 120 microm isotropic resolution revealed spatially distinct signal increases 6-48 hr after subcutaneous application of MnCl(2) (20 mg/kg). The effects result from a shortening of the water proton T(1) relaxation time due to the pr...
journal_title:Magnetic resonance in medicine
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更新日期:2002-11-01 00:00:00
abstract::In the dynamic nuclear polarization process, microwave irradiation facilitates exchange of polarization from a radical's unpaired electron to nuclear spins at cryogenic temperatures, increasing polarization by >10,000. Doping samples with Gd(3+) ions further increases the achievable solid-state polarization. However, ...
journal_title:Magnetic resonance in medicine
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更新日期:2012-12-01 00:00:00
abstract::In MRI, imaging using receiving coil arrays with a large number of elements is an area of growing interest. With increasing channel numbers for parallel acquisition, longer reconstruction times have become a significant concern. Channel reduction techniques have been proposed to reduce the processing time of channel-b...
journal_title:Magnetic resonance in medicine
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更新日期:2012-03-01 00:00:00
abstract::A modified Prony method (MPM) was applied to analyze the main signals present in spatially resolved 31P NMR spectra of MCF7 breast tumors implanted in nude mice. First, the method was tested on synthetic data to establish its limits of reliability. Its performance with respect to peak identification and quantification...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910380219
更新日期:1997-08-01 00:00:00
abstract::The potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison, was studied with rat liver imaging at 7 T. Optison suspension in two different dos...
journal_title:Magnetic resonance in medicine
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abstract::Phase-contrast magnetic resonance imaging is subject to numerous sources of error, which decrease clinical confidence in the reported measures. This work outlines how stationary perivascular fat can impart a significant chemical shift induced phase-contrast magnetic resonance imaging measurement error using computatio...
journal_title:Magnetic resonance in medicine
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更新日期:2013-02-01 00:00:00
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