Abstract:
:A modified Prony method (MPM) was applied to analyze the main signals present in spatially resolved 31P NMR spectra of MCF7 breast tumors implanted in nude mice. First, the method was tested on synthetic data to establish its limits of reliability. Its performance with respect to peak identification and quantification of signal intensities was then exploited on data from three implanted tumors during hormonal manipulation with estrogen and the antiestrogenic drug tamoxifen. The phosphomonoester peak was resolved into phosphocholine (PC) and phosphoethanolamine (PE). Treatment with tamoxifen led to a significant reduction in the PE to PE+PC peak amplitude ratio in the tumors under consideration. MPM analysis also revealed the presence of two different inorganic phosphate pools: a larger acidic pool and a smaller alkaline pool during estrogen-induced growth and the reverse during tumor regression.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Viti V,Ragona R,Guidoni L,Barone P,Furman E,Degani Hdoi
10.1002/mrm.1910380219subject
Has Abstractpub_date
1997-08-01 00:00:00pages
285-95issue
2eissn
0740-3194issn
1522-2594journal_volume
38pub_type
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