Abstract:
PURPOSE:To determine the in vitro accuracy, test-retest repeatability, and interplatform reproducibility of T1 quantification protocols used for dynamic contrast-enhanced MRI at 1.5 and 3 T. METHODS:A T1 phantom with 14 samples was imaged at eight centers with a common inversion-recovery spin-echo (IR-SE) protocol and a variable flip angle (VFA) protocol using seven flip angles, as well as site-specific protocols (VFA with different flip angles, variable repetition time, proton density, and Look-Locker inversion recovery). Factors influencing the accuracy (deviation from reference NMR T1 measurements) and repeatability were assessed using general linear mixed models. Interplatform reproducibility was assessed using coefficients of variation. RESULTS:For the common IR-SE protocol, accuracy (median error across platforms = 1.4-5.5%) was influenced predominantly by T1 sample (P < 10-6 ), whereas test-retest repeatability (median error = 0.2-8.3%) was influenced by the scanner (P < 10-6 ). For the common VFA protocol, accuracy (median error = 5.7-32.2%) was influenced by field strength (P = 0.006), whereas repeatability (median error = 0.7-25.8%) was influenced by the scanner (P < 0.0001). Interplatform reproducibility with the common VFA was lower at 3 T than 1.5 T (P = 0.004), and lower than that of the common IR-SE protocol (coefficient of variation 1.5T: VFA/IR-SE = 11.13%/8.21%, P = 0.028; 3 T: VFA/IR-SE = 22.87%/5.46%, P = 0.001). Among the site-specific protocols, Look-Locker inversion recovery and VFA (2-3 flip angles) protocols showed the best accuracy and repeatability (errors < 15%). CONCLUSIONS:The VFA protocols with 2 to 3 flip angles optimized for different applications achieved acceptable balance of extensive spatial coverage, accuracy, and repeatability in T1 quantification (errors < 15%). Further optimization in terms of flip-angle choice for each tissue application, and the use of B1 correction, are needed to improve the robustness of VFA protocols for T1 mapping. Magn Reson Med 79:2564-2575, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Bane O,Hectors SJ,Wagner M,Arlinghaus LL,Aryal MP,Cao Y,Chenevert TL,Fennessy F,Huang W,Hylton NM,Kalpathy-Cramer J,Keenan KE,Malyarenko DI,Mulkern RV,Newitt DC,Russek SE,Stupic KF,Tudorica A,Wilmes LJ,Yankeelov TEdoi
10.1002/mrm.26903subject
Has Abstractpub_date
2018-05-01 00:00:00pages
2564-2575issue
5eissn
0740-3194issn
1522-2594journal_volume
79pub_type
杂志文章abstract::This article describes an EPR spectrometer specifically designed and constructed for EPR spectroscopy in humans. The spectrometer is based on a permanent magnet, suitable for measurements at 1200 MHz. The magnet has a full 50 cm gap between the poles, which facilitates accurate and comfortable placement of the subject...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/mrm.20689
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abstract::The exponential clearance rate constant, (kappa), and filtration fraction (FF) have been measured for dialysis of Gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) (Magnevist, Berlex, Wayne, NJ) solutions by using a Look-Locker imaging technique under conditions of flow. The measured values of kappa for the Baxt...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910360412
更新日期:1996-10-01 00:00:00
abstract::Patient-specific radiofrequency shimming in high-field MRI strengthens the need for online, patient-specific specific absorption rate (SAR) monitoring. Numerical simulation is currently most effective for this purpose but may require a patient-specific dielectric model. To investigate whether a generic model may be co...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.24378
更新日期:2013-05-01 00:00:00
abstract::High-field MRI scanners are, in principle, well suited for mouse studies; however, many high-field magnets employ a vertical design that may influence the physiological state of the rodent. The purpose of this study was to investigate the orthostatic response of cerebral blood flow (CBF) in mice during a prolonged MR ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.20621
更新日期:2005-10-01 00:00:00
abstract::The investigation of flow behavior in coronary arteries is of great importance for an understanding of heart failure and heart regulation mechanisms. The purpose of the present study was to demonstrate that flow velocity can be quantified in the coronary arteries of the isolated rat heart with high-resolution phase co...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.10563
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abstract::A fast, two-coil, pseudo-continuous labeling scheme is presented. This new scheme permits the collection of a multislice subtraction pair in <3 s, depending on the subject's arterial transit times. The method consists of acquiring both control and tag images immediately after a labeling period that matches the arteria...
journal_title:Magnetic resonance in medicine
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abstract::This communication describes the design and application of a receiver coil operating at liquid nitrogen temperature and intended as a surface coil in a whole-body imager. Its particular application is seen as the external receiver for parasitic internal or implanted detectors. ...
journal_title:Magnetic resonance in medicine
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abstract::Phased-array coils distribute the high signal-to-noise ratio (SNR) performance of their small component surface coils over the larger area covered by the entire array. The inhomogeneous sensitivity profiles of the component surface coils result in images with very high signal near the phased-array and decreased signal...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910350419
更新日期:1996-04-01 00:00:00
abstract:PURPOSE:The optic nerve (ON) represents the sole pathway between the eyes and brain; consequently, diseases of the ON can have dramatic effects on vision. However, quantitative magnetization transfer (qMT) applications in the ON have been limited to ex vivo studies, in part because of the fatty connective tissue that s...
journal_title:Magnetic resonance in medicine
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abstract:PURPOSE:To develop a pulsed CEST magnetization-transfer method for rapidly acquiring relayed nuclear Overhauser enhancement (rNOE)-weighted images with magnetic transfer contrast (MTC) suppression at clinical field strength (3 T). METHODS:Using a pulsed CEST magnetization-transfer method with low saturation powers (B1...
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更新日期:2021-01-01 00:00:00
abstract::In vivo echo-planar MR imaging was used to measure apparent diffusion coefficients (ADC) of cerebral tissues in a comprehensive noninvasive evaluation of early ischemic brain damage induced by occlusion of the middle cerebral artery (MCA) in a cat model of acute regional stroke. Within 10 min after arterial occlusion,...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910190220
更新日期:1991-06-01 00:00:00
abstract::Gadobutrol (Gd-Bt; Gadovist(R), Schering AG) is a 1-M Gadolinium (Gd)-based contrast agent. Its higher Gd concentration allows for reduction of injection volumes in first pass contrast-enhanced MR angiography (CE-MRA) and should increase bolus sharpness and image quality. However, ambivalent results were reported. In ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21345
更新日期:2008-01-01 00:00:00
abstract::Acute normovolemic hemodilution (HD) was induced in anesthetized rats to assess the effect of changes in hematocrit (Hct) on signal intensity in T2*-weighted magnetic resonance (MR) images. Other relevant physiological parameters were maintained invariant. Two degrees of HD were induced: mild (Hct reduced from 42.6+/-...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910400611
更新日期:1998-12-01 00:00:00
abstract:PURPOSE:MR-based quantification of liver magnetic susceptibility may enable field strength-independent measurement of liver iron concentration (LIC). However, susceptibility quantification is challenging, due to nonlocal effects of susceptibility on the B0 field. The purpose of this work is to demonstrate feasibility o...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24848
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:We incorporate simultaneous multislice (SMS) acquisition into MR fingerprinting (MRF) to accelerate the MRF acquisition. METHODS:The t-Blipped SMS-MRF method is achieved by adding a Gz blip before each data acquisition window and balancing it with a Gz blip of opposing polarity at the end of each TR. Thus the ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25799
更新日期:2016-05-01 00:00:00
abstract::Aim of the study was to determine distribution and depletion patterns of intramyocellular lipids (IMCL) in leg muscles before and after two types of standardized endurance exercise. ¹H-magnetic resonance spectroscopic imaging was performed (1) in the thigh of eight-trained cyclists after exercising on an ergometer for...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/mrm.24168
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To investigate the relative gain in sensitivity of five histology coils designed in-house to accommodate tissue sections of various sizes and compare with commercial mouse head coils. METHODS:The coil set was tailored to house tissue sections ranging from 5 to1000 µm encased in either glass slides or coverslip...
journal_title:Magnetic resonance in medicine
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更新日期:2014-05-01 00:00:00
abstract::Formalin fixation of tissue is a common laboratory practice. A direct comparison of diffusion tensor imaging (DTI) parameters from mouse brains before (in vivo) and after (ex vivo) formalin fixation is reported herein. Five diffusion indices were examined in a cohort of seven mice: relative anisotropy (RA), directiona...
journal_title:Magnetic resonance in medicine
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更新日期:2003-10-01 00:00:00
abstract::Standard MRI cine exams for the study of cardiac function are segmented over several heartbeats and thus require a breath-hold to minimize breathing motion artifacts, which is a current limitation of this approach. The purpose of this study was to develop a method for the measurement and correction of respiratory moti...
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更新日期:2008-09-01 00:00:00
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更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To demonstrate how triple diffusion encoding (TDE) MRI can be applied to separately estimate the intra-axonal and extra-axonal diffusion tensors in white matter (WM). METHODS:Using a TDE pulse sequence with an axially symmetric b-matrix, diffusion MRI data were acquired at 3T for 3 healthy adults with an axial...
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更新日期:2020-06-01 00:00:00
abstract::Nuclear Overhauser effect (NOE) enhancements and relaxation times of 31P metabolites in human calf were measured in 12 volunteers (4 men and 8 women) at 1.5 T using a dual tuned four-ring birdcage. The NOE enhancements of inorganic phosphate (Pi), phosphocreatine (PCr), gamma-, alpha-, and beta-nucleoside triphosphate...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910330316
更新日期:1995-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21039
更新日期:2006-10-01 00:00:00
abstract::31P NMR spectroscopy was used to study renal allografts in rats subjected to allograft rejection, cyclosporine toxicity, ischemia, and ureteral obstruction. Parameters of relative peak areas and intracellular pH were accurately distinguished among the different causes of graft dysfunction. Ureteral obstruction was cle...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910050405
更新日期:1987-10-01 00:00:00
abstract::In this study, we report the use of a novel ultrashort echo time T(1)rhoT(1) sequence that combines a spin-lock preparation pulse with a two-dimensional ultrashort echo time sequence of a nominal echo time 8 microsec. The ultrashort echo time-T(1)rho sequence was employed to quantify T(1)rho in short T(2) tissues incl...
journal_title:Magnetic resonance in medicine
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更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To develop a wideband cardiac perfusion pulse sequence and test whether it is capable of suppressing image artifacts in patients with a cardiac implantable electronic device (CIED), while not exceeding the specific absorption rate (SAR) limit (2.0 W/kg). METHODS:A wideband perfusion pulse sequence was develope...
journal_title:Magnetic resonance in medicine
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更新日期:2019-02-01 00:00:00
abstract::It is shown that the effect of pH changes can be measured in proton NMR spectra through the pH sensitivity of the signal intensities of metabolite protons exchanging with water. To observe this phenomenon, pulse sequences must be used that can sensitively observe these exchangeable protons under physiological conditio...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910400105
更新日期:1998-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2016-10-01 00:00:00
abstract::For clinical 31P MR spectroscopic imaging (MRSI) studies, where signal averaging is necessary, some improvement of sensitivity and spatial response function may be achieved by acquiring data over a spherical k-space volume and varying the number of averages acquired in proportion to the desired spatial filter. Eight d...
journal_title:Magnetic resonance in medicine
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更新日期:1996-09-01 00:00:00
abstract::Image contrast with gradient-recalled echo sequences (GRE) used for fMRI can have both blood oxygen level-dependent (BOLD) and inflow components, and the latter is often undesirable. A dual-echo technique can be used to differentiate these mechanisms, because modulation of signal from inflow is common to both echoes, ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350306
更新日期:1996-03-01 00:00:00