Abstract:
PURPOSE:Magnetic resonance-guided high-intensity focused ultrasound is considered to be a promising treatment for localized cancer in abdominal organs such as liver, pancreas, or kidney. Abdominal motion, anatomical arrangement, and required sustained sonication are the main challenges. METHODS:MR acquisition consisted of thermometry performed with segmented gradient-recalled echo echo-planar imaging, and a segment-based one-dimensional MR navigator parallel to the main axis of motion to track the organ motion. This tracking information was used in real-time for: (i) prospective motion correction of MR thermometry and (ii) HIFU focal point position lock-on target. Ex vivo experiments were performed on a sheep liver and a turkey pectoral muscle using a motion demonstrator, while in vivo experiments were conducted on two sheep liver. RESULTS:Prospective motion correction of MR thermometry yielded good signal-to-noise ratio (range, 25 to 35) and low geometric distortion due to the use of segmented EPI. HIFU focal point lock-on target yielded isotropic in-plane thermal build-up. The feasibility of in vivo intercostal liver treatment was demonstrated in sheep. CONCLUSION:The presented method demonstrated in moving phantoms and breathing sheep accurate motion-compensated MR thermometry and precise HIFU focal point lock-on target using only real-time pencil-beam navigator tracking information, making it applicable without any pretreatment data acquisition or organ motion modeling.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Celicanin Z,Auboiroux V,Bieri O,Petrusca L,Santini F,Viallon M,Scheffler K,Salomir Rdoi
10.1002/mrm.25017subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1087-95issue
4eissn
0740-3194issn
1522-2594journal_volume
72pub_type
杂志文章abstract:PURPOSE:Within multiple sclerosis (MS) lesions iron is present in chronically activated microglia. Thus, iron detection with MRI might provide a biomarker for chronic inflammation within lesions. Here, we examine contributions of iron and myelin to magnetic susceptibility of lesions on quantitative susceptibility mappi...
journal_title:Magnetic resonance in medicine
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abstract::Gadobutrol (Gd-Bt; Gadovist(R), Schering AG) is a 1-M Gadolinium (Gd)-based contrast agent. Its higher Gd concentration allows for reduction of injection volumes in first pass contrast-enhanced MR angiography (CE-MRA) and should increase bolus sharpness and image quality. However, ambivalent results were reported. In ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21345
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.22169
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abstract::A multiple quantum filter strategy is presented for spectrally discriminating metabolites with strongly coupled spins from those whose spins are either uncoupled or weakly coupled. The strategy also includes a means for selectively suppressing the background multiplets of metabolites that also have strongly coupled sp...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10697
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910340608
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abstract::In order to obtain proton magnetic resonance spectra from the normal human kidney in vivo, we employed a STEAM sequence with delay times TE = 10 ms and TM = 30 ms. Signals are attenuated during STEAM sequences by J-coupling effects and by macroscopic movement of the sample. The combination of short echo times and resp...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910310503
更新日期:1994-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
abstract::Phase-contrast (PC) MRI is a noninvasive method for imaging blood and tissue velocity. PC experiments are typically segmented into many cardiac cycles in order to obtain sufficient spatial and temporal resolution, and thus require a gating signal to properly combine the data from multiple cardiac cycles. Although the ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20187
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:This study evaluates biochemical imbalances in a rat model that reflects dysfunctional pathways in migraine. The high sensitivity and spectral dispersion available to 1 H MRS at 21.1 T expands metabolic profiling in this migraine model to include lactate (Lac), taurine (Tau), aspartate, and Gly-a mixture of gly...
journal_title:Magnetic resonance in medicine
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更新日期:2018-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2018-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24899
更新日期:2014-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910320603
更新日期:1994-12-01 00:00:00
abstract::MRI after a constant infusion (CI) of Gd-DTPA has been used to identify the extent of myocardial infarction (MI). However, Gd-DTPA-enhanced "viability" imaging is more commonly performed with a bolus (for "delayed-enhancement" (DE) imaging). This study sought to determine how image delay time and time postinfarction i...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20236
更新日期:2004-11-01 00:00:00
abstract:PURPOSE:Acquisition of high-resolution imaging data using multiple excitations without the sensitivity to fluctuations of the transverse magnetization phase, which is a major problem of multi-shot MRI. THEORY AND METHODS:The concept of superresolution MRI based on microscopic tagging is analyzed using an analogy with ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27209
更新日期:2018-12-01 00:00:00
abstract::A method is described for multislice imaging by means of rf pulses which contain a multifrequency excitation spectrum. These pulses label each slice by an individual signal phase and allow the separation of the signals from all the slices by subsequent add/subtract procedures. The image sensitivity corresponds to the ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910060315
更新日期:1988-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.27192
更新日期:2018-11-01 00:00:00
abstract::Techniques are described for the (31)P NMR analysis of glycerophospholipid (PL) headgroup and molecular species in brain. The (31)P NMR spectrum of PLs from human temporal cortex, solubilized in aqueous Na cholate, typically showed 3 major resonances, assigned to phosphatidylcholine (PC) molecular species containing 0...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200008)44:2<215::aid-mrm8>3.0.co
更新日期:2000-08-01 00:00:00
abstract::Magnetic resonance imaging has achieved clinical importance and has become the primary tool in the investigation of head, spinal cord, pelvis, cancellous bone, pericardium (with gating), gallbladder, lymph node masses, and very soon, in the evaluation of joints. In many areas, particularly with respiratory and ECG gat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章,评审
doi:10.1002/mrm.1910020402
更新日期:1985-08-01 00:00:00
abstract:PURPOSE:Reliable monitoring of tissue nicotinamide adenine dinucleotide (NAD+ ) concentration may provide insights on its roles in normal and pathological aging. In the present study, we report a 1 H MRS pulse sequence for the in vivo, localized 1 H MRS detection of NAD+ from the human brain. METHODS:Studies were carr...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.27971
更新日期:2020-03-01 00:00:00
abstract::The estrogen receptor (ER) is a major prognostic biomarker of breast cancer, currently determined in surgical specimens by immunohistochemistry. Two new ER-targeted probes, pyridine-tetra-acetate-Gd chelate (PTA-Gd) conjugated either to 17β-estradiol (EPTA-Gd) or to tamoxifen (TPTA-Gd), were explored as contrast agent...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.24442
更新日期:2013-07-01 00:00:00
abstract::Three-dimensional magnetization-prepared (MP) MR angiography (MRA) was applied to the carotid and vertebral arteries by using ECG triggering, a slab selective RF inversion pulse, centric phase encoding and acquisition during diastole. Both theoretically and experimentally, the MP MRA sequence was shown to perform well...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910370219
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journal_title:Magnetic resonance in medicine
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doi:10.1002/(sici)1522-2594(199905)41:5<964::aid-mrm16
更新日期:1999-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910060111
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:To evaluate proton density fat fraction (PDFF) and R2* as markers of bone marrow composition and structure in inflamed bone in patients with spondyloarthritis. METHODS:Phantoms containing fat, water, and trabecular bone were constructed with proton density fat fraction (PDFF) and bone mineral density (BMD) val...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26729
更新日期:2018-02-01 00:00:00
abstract::The use of phase correlation to detect rigid-body translational motion is reviewed and applied to individual echotrains in turbo-spin-echo data acquisition. It is shown that when the same echotrain is acquired twice, the subsampled correlation provides an array of delta-functions, from which the motion that occurred b...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21883
更新日期:2009-03-01 00:00:00
abstract::Three-dimensional spatial-spectral radiofrequency pulses using a stack-of-spirals trajectory can achieve two-dimensional spatial localization and one-dimensional spectral selection simultaneously. These pulses are useful, for example, in reduced field-of-view applications that also require frequency specificity such a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22209
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To facilitate assessment of RF power deposition and temperature rise within the breast, we present a method to seamlessly join heterogeneous breast models with standard whole-body models and demonstrate simulations at 7 T. METHODS:Finite-difference time-domain electromagnetic and bioheat simulations are perfor...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.27395
更新日期:2019-02-01 00:00:00
abstract::Vascular-space-occupancy (VASO) MRI exploits the difference between blood and tissue T1 to null blood signal and measure cerebral blood volume changes using the residual tissue signal. VASO imaging is more difficult at higher field because of sensitivity loss due to the convergence of tissue and blood T1 values and in...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.24334
更新日期:2013-04-01 00:00:00
abstract::In order to determine if an increase in myocardial oxygen consumption is accompanied by changes in high energy phosphates in normal subjects and patients with dilated cardiomyopathy, phosphorus-31 spectra were acquired under resting conditions and during dobutamine infusion. In seven normal subjects, dobutamine raised...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:1992-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26805
更新日期:2018-03-01 00:00:00