Proton NMR spectroscopy of solvent-saturable resonances: a new approach to study pH effects in situ.

Abstract:

:It is shown that the effect of pH changes can be measured in proton NMR spectra through the pH sensitivity of the signal intensities of metabolite protons exchanging with water. To observe this phenomenon, pulse sequences must be used that can sensitively observe these exchangeable protons under physiological conditions, which is achieved by avoiding magnetization transfer signal losses due to water saturation for solvent suppression purposes. These methods provide an order-of-magnitude enhancement of many signals between 5 and 10 ppm, containing both N-bound protons as well as aromatic C-H protons coupled to them, the intensity of which is influenced by exchange-relayed saturation. As a first application, the effects of pH change on these resonances are studied ex vivo (perfused cells) and in vivo (cat brain).

journal_name

Magn Reson Med

authors

Mori S,Eleff SM,Pilatus U,Mori N,van Zijl PC

doi

10.1002/mrm.1910400105

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

36-42

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

40

pub_type

杂志文章
  • Sensitivity of MR diffusion measurements to variations in intracellular structure: effects of nuclear size.

    abstract::Magnetic resonance imaging measurements of the apparent rate of water diffusion in tumors are sensitive to variations in tissue cellularity, which have been shown useful for characterizing tumors and their responses to treatments. However, because of technical limitations on most MRI systems, conventional pulse gradie...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21793

    authors: Xu J,Does MD,Gore JC

    更新日期:2009-04-01 00:00:00

  • Rigid-body motion correction with self-navigation MRI.

    abstract::The use of phase correlation to detect rigid-body translational motion is reviewed and applied to individual echotrains in turbo-spin-echo data acquisition. It is shown that when the same echotrain is acquired twice, the subsampled correlation provides an array of delta-functions, from which the motion that occurred b...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21883

    authors: Mendes J,Kholmovski E,Parker DL

    更新日期:2009-03-01 00:00:00

  • Fast oxygen-enhanced multislice imaging of the lung using parallel acquisition techniques.

    abstract::The purpose of this study was to evaluate an optimized multislice acquisition technique for oxygen-enhanced MRI of the lung using slice-selective inversion and refocusing pulses in combination with parallel imaging. An inversion recovery HASTE sequence was implemented with respiratory triggering to perform imaging in ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20495

    authors: Dietrich O,Losert C,Attenberger U,Fasol U,Peller M,Nikolaou K,Reiser MF,Schoenberg SO

    更新日期:2005-06-01 00:00:00

  • The analytic theory, optimization, and performance of transparent pulses.

    abstract::Transparent pulses are defined by the property of having no net effect on stationary spins, while selectively nutating and dephasing flowing spins. They are derived from the inverse scattering transform, a nonlinear extension of the inverse Fourier transform. They can be used as presaturation pulses to suppress select...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910240212

    authors: Buonocore MH

    更新日期:1992-04-01 00:00:00

  • Identification of signal bias in the variable flip angle method by linear display of the algebraic Ernst equation.

    abstract::A novel linear parameterization for the variable flip angle method for longitudinal relaxation time T(1) quantification from spoiled steady state MRI is derived from the half angle tangent transform, τ, of the flip angle. Plotting the signal S at coordinates x=Sτ and y=S/τ, respectively, establishes a line that render...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22849

    authors: Helms G,Dathe H,Weiskopf N,Dechent P

    更新日期:2011-09-01 00:00:00

  • Quantification of perfusion in murine myocardium: A retrospectively triggered T1 -based ASL method using model-based reconstruction.

    abstract:PURPOSE:A method for the quantification of perfusion in murine myocardium is demonstrated. The method allows for the reconstruction of perfusion maps on arbitrary time points in the heart cycle while addressing problems that arise due to the irregular heart beat of mice. METHODS:A flow-sensitive alternating inversion ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25526

    authors: Gutjahr FT,Kampf T,Winter P,Meyer CB,Williams T,Jakob PM,Bauer WR,Ziener CH,Helluy X

    更新日期:2015-12-01 00:00:00

  • Cardiac tagging with breath-hold cine MRI.

    abstract::A method is presented for measuring myocardial deformation in a breath-hold with tagged cine MRI. Tagged cine images of human hearts are obtained in arbitrary oblique planes on a standard imager with as few as four heartbeats. The scan time has been reduced 16- to 64-fold from previous techniques. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910280214

    authors: McVeigh ER,Atalar E

    更新日期:1992-12-01 00:00:00

  • On the origin of paramagnetic inhomogeneity effects in blood.

    abstract::Hydrogen, sodium, and fluorine (added F-) NMR spectra of venous and oxygenated blood were measured. The fluorine resonance was seen as a single peak in both samples, and all three resonances exhibited the same deoxy-oxy shift. Because F- exchanges slowly across the red cell membrane, and because sodium is 95% extracel...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910120210

    authors: Brooks RA,Brunetti A,Alger JR,Di Chiro G

    更新日期:1989-11-01 00:00:00

  • S5FP: spectrally selective suppression with steady state free precession.

    abstract::A method is presented that employs the inherent spectral selectivity of the Steady-State Free Precession (SSFP) pulse sequence to provide a spectral band of suppression. At TE = TR/2, SSFP partitions the magnetization into two phase-opposed spectral components. Z-storing one of these components simultaneously further ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20633

    authors: Derbyshire JA,Herzka DA,McVeigh ER

    更新日期:2005-10-01 00:00:00

  • Quantitative MRI of Gd-DTPA uptake in tumors: response to photodynamic therapy.

    abstract::A partial saturation method is described for obtaining rapid images of tissue 1H spin-lattice relaxation rates following administration of the paramagnetic contrast agent gadolinium-diethylenetriaminepentaacetate. The paramagnetic contribution to the relaxation rates is proportional to the concentration of contrast ag...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310308

    authors: Kennedy SD,Szczepaniak LS,Gibson SL,Hilf R,Foster TH,Bryant RG

    更新日期:1994-03-01 00:00:00

  • Extended ISIS sequences insensitive to T(1) smearing.

    abstract::Image selected in vivo spectroscopy (ISIS) is a volume selection method often used for in vivo (31)P MRS, since it is suitable for measurements of substances with short T(2). However, ISIS can suffer from significant signal contributions caused by T(1) smearing from regions outside the VOI. A computer model was develo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200010)44:4<546::aid-mrm8>3.0.co

    authors: Ljungberg M,Starck G,Vikhoff-Baaz B,Alpsten M,Ekholm S,Forssell-Aronsson E

    更新日期:2000-10-01 00:00:00

  • Radial single-shot STEAM MRI.

    abstract::Rapid MR imaging using the stimulated echo acquisition mode (STEAM) technique yields single-shot images without any sensitivity to resonance offset effects. However, the absence of susceptibility-induced signal voids or geometric distortions is at the expense of a somewhat lower signal-to-noise ratio than EPI. As a co...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21401

    authors: Block KT,Frahm J

    更新日期:2008-04-01 00:00:00

  • Transmit SENSE.

    abstract::The idea of using parallel imaging to shorten the acquisition time by the simultaneous use of multiple receive coils can be adapted for the parallel transmission of a spatially-selective multidimensional RF pulse. As in data acquisition, a multidimensional RF pulse follows a certain k-space trajectory. Shortening this...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10353

    authors: Katscher U,Börnert P,Leussler C,van den Brink JS

    更新日期:2003-01-01 00:00:00

  • Fast mapping of myocardial blood flow with MR first-pass perfusion imaging.

    abstract::Accurate and fast quantification of myocardial blood flow (MBF) with MR first-pass perfusion imaging techniques on a pixel-by-pixel basis remains difficult due to relatively long calculation times and noise-sensitive algorithms. In this study, Zierler's central volume principle was used to develop an algorithm for the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21559

    authors: Goldstein TA,Jerosch-Herold M,Misselwitz B,Zhang H,Gropler RJ,Zheng J

    更新日期:2008-06-01 00:00:00

  • Chemically induced analgesic nephropathy in the rat monitored by proton-electron double-resonance imaging (PEDRI).

    abstract::Proton-electron double-resonance imaging (PEDRI) was used to assess renal function by monitoring the flow of the exogenous nitroxide free radical proxyl carboxylic acid (PCA) through normal and injured kidneys in the living rat. Kidney damage was induced by treatment with 2-bromoethylamine (BEA), which provides a well...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910400214

    authors: Seimenis I,Foster MA,Lurie DJ,Hutchison JM,Whiting PH,Payne S

    更新日期:1998-08-01 00:00:00

  • Localized 1H NMR measurements of 2-pyrrolidinone in human brain in vivo.

    abstract::Localized 1H NMR homonuclear J editing spectroscopy was used to measure the concentration of 2-pyrrolidinone (PRDN) in the human occipital lobe of five normal and six epileptic subjects taking vigabatrin. PRDN is a lactam cyclization product of gamma-aminobutyric acid (GABA). From a localized volume of 13.5 cm3 in the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199905)41:5<889::aid-mrm6>

    authors: Hyder F,Petroff OA,Mattson RH,Rothman DL

    更新日期:1999-05-01 00:00:00

  • Ultra-rapid gradient echo imaging.

    abstract::A novel ultra-rapid gradient echo (URGE) NMR imaging technique is introduced, which is capable of continuous high resolution 3D scanning while neither subject to fast gradient switching nor excessive RF power deposition. Sampling free induction decays instead of creating spin echoes enables maintaining a workable stea...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910330123

    authors: Heid O,Deimling M,Huk WJ

    更新日期:1995-01-01 00:00:00

  • Ultrashort echo time spectroscopic imaging (UTESI) of cortical bone.

    abstract::Cortical bone in the mature skeleton has a short T(2)* and produces no detectable signal with conventional MR sequences. A two-dimensional ultrashort echo time (UTE) sequence employing half radio frequency (RF) pulse excitations and radial ramp sampling reduces the effective TE to 8 micros and is capable of detecting ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21397

    authors: Du J,Hamilton G,Takahashi A,Bydder M,Chung CB

    更新日期:2007-11-01 00:00:00

  • A torque balance measurement of anisotropy of the magnetic susceptibility in white matter.

    abstract:PURPOSE:Recent MRI studies have suggested that the magnetic susceptibility of white matter (WM) in the human brain is anisotropic, providing a new contrast mechanism for the visualization of fiber bundles and allowing the extraction of cellular compartment-specific information. This study provides an independent confir...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25524

    authors: van Gelderen P,Mandelkow H,de Zwart JA,Duyn JH

    更新日期:2015-11-01 00:00:00

  • Novel RF coil geometry for lower extremity imaging.

    abstract::A receive-only phased-array coil was designed to image the lower extremities. The array consists of four volume coils placed on two cylindrical formers. The coil array has the ability to image both legs simultaneously over a 40 cm longitudinal field of view (FOV). Experiments using phantoms show an increase in signal-...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10712

    authors: Brown R,Mareyam A,Reid E,Wang Y

    更新日期:2004-03-01 00:00:00

  • Single-shot two-echo technique for simultaneous measurement of GABA and creatine in the human brain in vivo.

    abstract::A single-shot, two-echo method for the simultaneous detection of multiple-quantum (MQ)-filtered gamma-aminobutyric acid (GABA) and creatine (Cr) was developed and demonstrated in the human brain in vivo at 3 Tesla. The simultaneously measured Cr singlet served as a navigator for the spectral phase of GABA and any freq...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20082

    authors: Choi IY,Lee SP,Merkle H,Shen J

    更新日期:2004-06-01 00:00:00

  • Estimates of systolic and diastolic myocardial blood flow by dynamic contrast-enhanced MRI.

    abstract::Myocardial blood flow varies during the cardiac cycle in response to pulsatile changes in epicardial circulation and cyclical variation in myocardial tension. First-pass assessment of myocardial perfusion by dynamic contrast-enhanced MRI is one of the most challenging applications of MRI because of the spatial and tem...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22538

    authors: Radjenovic A,Biglands JD,Larghat A,Ridgway JP,Ball SG,Greenwood JP,Jerosch-Herold M,Plein S

    更新日期:2010-12-01 00:00:00

  • Combined dynamic contrast-enhanced liver MRI and MRA using interleaved variable density sampling.

    abstract:PURPOSE:To develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent. METHODS:An interleaved variable density (IVD) undersampling pattern was implemented i...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25195

    authors: Salmani Rahimi M,Korosec FR,Wang K,Holmes JH,Motosugi U,Bannas P,Reeder SB

    更新日期:2015-03-01 00:00:00

  • Modification of embolic-PVA particles with MR contrast agents.

    abstract::We report the synthesis and characterization of polyvinyl alcohol (PVA) embolic particles modified with a clinically approved magnetic resonance (MR) contrast agent. PVA particles are used during transcatheter arterial embolization (TAE) procedures and this minimally invasive technique is a widely employed treatment f...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21518

    authors: Cilliers R,Song Y,Kohlmeir EK,Larson AC,Omary RA,Meade TJ

    更新日期:2008-04-01 00:00:00

  • Temporal frequency analysis of dynamic MRI techniques.

    abstract::Dynamic imaging strategies often involve updating certain areas of k-space (i.e., the low spatial frequencies) more frequently than others. However, important dynamic signal changes may occur anywhere in k-space. In this study, a dynamic k-space sampling analysis method was developed to determine the energy error asso...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1074

    authors: Wu Y,Alexander AL

    更新日期:2001-04-01 00:00:00

  • Fast nonlinear susceptibility inversion with variational regularization.

    abstract:PURPOSE:Quantitative susceptibility mapping can be performed through the minimization of a function consisting of data fidelity and regularization terms. For data consistency, a Gaussian-phase noise distribution is often assumed, which breaks down when the signal-to-noise ratio is low. A previously proposed alternative...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27073

    authors: Milovic C,Bilgic B,Zhao B,Acosta-Cabronero J,Tejos C

    更新日期:2018-08-01 00:00:00

  • Shielded-coaxial-cable coils as receive and transceive array elements for 7T human MRI.

    abstract:PURPOSE:To investigate the use of shielded-coaxial-cable (SCC) coils as elements for multi-channel receive-only and transceive arrays for 7T human MRI and to compare their performance with equivalently sized conventional loop coils. METHODS:The SCC coil element consists of a coaxial loop with interrupted central condu...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27964

    authors: Ruytenberg T,Webb A,Zivkovic I

    更新日期:2020-03-01 00:00:00

  • Atraumatic quantitation of cerebral perfusion in cats by 19F magnetic resonance imaging.

    abstract::We have noninvasively produced low-resolution, quantitative nuclear magnetic resonance images of cerebral blood flow in 2-ml voxels in eight cats. Typical signal-to-noise of 4 to 1 was obtained in cerebral voxels in 16.5-s epochs. Mean flow during normocapnia (paCO2 = 39 +/- 4 mm Hg) and hypercapnia (paCO2 = 62 +/- 4 ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910280105

    authors: Branch CA,Ewing JR,Helpern JA,Ordidge RJ,Butt S,Welch KM

    更新日期:1992-11-01 00:00:00

  • Diffusion-weighted imaging of the human optic nerve: a new approach to evaluate optic neuritis in multiple sclerosis.

    abstract::The apparent diffusion coefficient (ADC) in the optic nerve was measured from diffusion-weighted magnetic resonance imaging using an intravoxel incoherent motion (IVIM) sequence. The subjects were seven normal volunteers and eight patients with multiple sclerosis (MS) with a total of four optic nerves with acute neuri...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910380317

    authors: Iwasawa T,Matoba H,Ogi A,Kurihara H,Saito K,Yoshida T,Matsubara S,Nozaki A

    更新日期:1997-09-01 00:00:00

  • Absolute quantification of myocardial perfusion under adenosine stress.

    abstract::The prebolus technique allows one to quantify perfusion in the human heart with a low variability by means of MRI. In this study the prebolus technique was used to determine quantitative perfusion values in the human heart under adenosine stress and to measure the myocardial perfusion reserve (MPR). Twelve healthy vol...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21020

    authors: Ritter C,Brackertz A,Sandstede J,Beer M,Hahn D,Köstler H

    更新日期:2006-10-01 00:00:00