A torque balance measurement of anisotropy of the magnetic susceptibility in white matter.

Abstract:

PURPOSE:Recent MRI studies have suggested that the magnetic susceptibility of white matter (WM) in the human brain is anisotropic, providing a new contrast mechanism for the visualization of fiber bundles and allowing the extraction of cellular compartment-specific information. This study provides an independent confirmation and quantification of this anisotropy. METHODS:Anisotropic magnetic susceptibility results in a torque exerted on WM when placed in a uniform magnetic field, tending to align the WM fibers with the field. To quantify the effect, excised spinal cord samples were placed in a torque balance inside the magnet of a 7 T MRI system and the magnetic torque was measured as function of orientation. RESULTS:All tissue samples (n = 5) showed orienting effects, confirming the presence of anisotropic susceptibility. Analysis of the magnetic torque resulted in reproducible values for the WM volume anisotropy that ranged from 13.6 to 19.2 ppb. CONCLUSION:The independently determined anisotropy values confirm estimates inferred from MRI experiments and validate the use of anisotropy to extract novel information about brain fiber structure and myelination.

journal_name

Magn Reson Med

authors

van Gelderen P,Mandelkow H,de Zwart JA,Duyn JH

doi

10.1002/mrm.25524

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1388-96

issue

5

eissn

0740-3194

issn

1522-2594

journal_volume

74

pub_type

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