Magnetic susceptibility measurement of insoluble solids by NMR: magnetic susceptibility of bone.

Abstract:

:Measurements of the volume magnetic susceptibility of solids using the classical Gouy balance approach are hampered by variations in apparent density of the packed powder. In this paper a quantitative NMR measurement of the volume magnetic susceptibility of powdered solids is described and the volume susceptibility of bone is reported. The technique is based on the measurement of changes in incremental linewidth (1/pi T2') induced in a marker fluid whose susceptibility can be predictably modified by changing the composition, such as by addition of a soluble diamagnetic compound. The spectroscopic linewidth of the marker fluid is determined by the susceptibility difference between the fluid and the suspended solid. Changes in the linewidth are accompanied by bulk magnetic susceptibility induced frequency shifts in the fluid resonance. Correlating the two dependencies allows measurement of the absolute volume susceptibility of the solid. The susceptibility of bovine rib bone was found to be -0.9 +/- 0.02 x -10(-6) (CGS) confirming previous estimates which suggested bone to be more diamagnetic than the marrow constituents. Knowledge of the susceptibility of bone is relevant in view of the growing interest in MRI osteodensitometric techniques.

journal_name

Magn Reson Med

authors

Hopkins JA,Wehrli FW

doi

10.1002/mrm.1910370404

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

494-500

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

37

pub_type

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