Dynamic changes in water ADC, energy metabolism, extracellular space volume, and tortuosity in neonatal rat brain during global ischemia.

Abstract:

:To obtain a better understanding of the mechanisms underlying early changes in the brain water apparent diffusion coefficient (ADC) observed in cerebral ischemia, dynamic changes in the ADC of water and in the energy status were measured at postnatal day 8 or 9 in neonatal rat brains after cardiac arrest using 1H MRS/MRI and 31P MRS, respectively. The time courses of the MR parameters were compared with changes in the extracellular space (ECS) volume fraction (alpha) and tortuosity (lambda), determined from concentration-time profiles of tetramethylammonium applied by iontophoresis. The data show a decrease of the ADC of tissue water after induction of global ischemia of which the time course strongly correlates with the time course of the decrease in the ECS volume fraction and the increase in ECS tortuosity. This indicates that cell swelling is an important cause for the ADC decrease of water.

journal_name

Magn Reson Med

authors

van der Toorn A,Syková E,Dijkhuizen RM,Vorísek I,Vargová L,Skobisová E,van Lookeren Campagne M,Reese T,Nicolay K

doi

10.1002/mrm.1910360110

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

52-60

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

36

pub_type

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