Abstract:
:To obtain a better understanding of the mechanisms underlying early changes in the brain water apparent diffusion coefficient (ADC) observed in cerebral ischemia, dynamic changes in the ADC of water and in the energy status were measured at postnatal day 8 or 9 in neonatal rat brains after cardiac arrest using 1H MRS/MRI and 31P MRS, respectively. The time courses of the MR parameters were compared with changes in the extracellular space (ECS) volume fraction (alpha) and tortuosity (lambda), determined from concentration-time profiles of tetramethylammonium applied by iontophoresis. The data show a decrease of the ADC of tissue water after induction of global ischemia of which the time course strongly correlates with the time course of the decrease in the ECS volume fraction and the increase in ECS tortuosity. This indicates that cell swelling is an important cause for the ADC decrease of water.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
van der Toorn A,Syková E,Dijkhuizen RM,Vorísek I,Vargová L,Skobisová E,van Lookeren Campagne M,Reese T,Nicolay Kdoi
10.1002/mrm.1910360110subject
Has Abstractpub_date
1996-07-01 00:00:00pages
52-60issue
1eissn
0740-3194issn
1522-2594journal_volume
36pub_type
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:2013-05-01 00:00:00
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更新日期:2015-02-01 00:00:00
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