MRI evaluation of myocardial perfusion without a contrast agent using magnetization transfer.


:We propose a new magnetic resonance imaging (MRI) technique that is sensitive to myocardial tissue perfusion that obviates the use of an extrinsic contrast agent. Significant advantages of such a technique are that it avoids accumulation of contrast agent when repeated studies are performed on the same subject and that it is completely noninvasive. The method makes use of a combination of magnetization transfer (MT) and T1sat (measured spin-lattice relaxation time in the presence of MT) weighting. In this Communication, we present observations from experiments with an isolated rat heart model that demonstrate increase of MT-weighted signal intensity and T1sat with flow. Also included are data showing that these effects can be made synergistic for enhancing the sensitivity to perfusion. We have observed about a 3% change in MT-weighted intensity and up to 10% change in MTT1sat-weighted intensity for a change of 1 ml/min in global flow rate.


Magn Reson Med


Prasad PV,Burstein D,Edelman RR




Has Abstract


1993-08-01 00:00:00












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    abstract::Magnetization transfer imaging (MT) and localized proton spectroscopy (1H-MRS) were utilized in the evaluation of lesions (high signal abnormalities on T2-weighted images) and normal-appearing white matter (NAWM) in multiple sclerosis (MS). Eleven patients with a clinical diagnosis of MS were independently evaluated w...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hiehle JF Jr,Lenkinski RE,Grossman RI,Dousset V,Ramer KN,Schnall MD,Cohen JA,Gonzalez-Scarano F

    更新日期:1994-09-01 00:00:00

  • The importance of correcting for signal drift in diffusion MRI.

    abstract:PURPOSE:To investigate previously unreported effects of signal drift as a result of temporal scanner instability on diffusion MRI data analysis and to propose a method to correct this signal drift. METHODS:We investigated the signal magnitude of non-diffusion-weighted EPI volumes in a series of diffusion-weighted imag...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Vos SB,Tax CM,Luijten PR,Ourselin S,Leemans A,Froeling M

    更新日期:2017-01-01 00:00:00

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    journal_title:Magnetic resonance in medicine

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    authors: Krasnosselskaia LV,Fullerton GD,Dodd SJ,Cameron IL

    更新日期:2005-08-01 00:00:00

  • Simultaneous image acquisition from the head (or body) coil and a surface coil.

    abstract::Any number of coils can in principle be used simultaneously and independently in magnetic resonance imaging if the mutual inductances are sufficiently small. Surface coils and head or body coils have equal sensitivity at some crossover depth of the order of 6 to 10 cm. Using a 7.5-cm-diameter surface coil that was int...

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    authors: Hyde JS,Froncisz W,Jesmanowicz A,Kneeland JB

    更新日期:1988-02-01 00:00:00

  • A new susceptibility-weighted image reconstruction method for the reduction of background phase artifacts.

    abstract:PURPOSE:To significantly reduce the background phase effects, especially at the air-tissue interface, and to enhance the desirable local structures of veins in susceptibility-weighted imaging. METHODS:In the proposed reconstruction method called Magnitude of Complex Filtering, a complex-valued magnetic resonance image...

    journal_title:Magnetic resonance in medicine

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    authors: Lee Y,Han Y,Park H

    更新日期:2014-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Nosel W,Trimble LA,Shen JF,Allen PS

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    pub_type: 杂志文章


    authors: Friman O,Cedefamn J,Lundberg P,Borga M,Knutsson H

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    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hennig J

    更新日期:1990-12-01 00:00:00

  • Modulation of the pharmacokinetics of macromolecular contrast material by avidin chase: MRI, optical, and inductively coupled plasma mass spectrometry tracking of triply labeled albumin.

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    authors: Dafni H,Gilead A,Nevo N,Eilam R,Harmelin A,Neeman M

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    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Otazo R,Mueller B,Ugurbil K,Wald L,Posse S

    更新日期:2006-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Pipe JG,Zwart NR,Aboussouan EA,Robison RK,Devaraj A,Johnson KO

    更新日期:2011-11-01 00:00:00

  • Detection of subnanotesla oscillatory magnetic fields using MRI.

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  • Evaluation of multicontrast MRI including fat suppression and inversion recovery spin echo for identification of intra-plaque hemorrhage and lipid core in human carotid plaque using the mahalanobis distance measure.

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    authors: te Boekhorst BC,van 't Klooster R,Bovens SM,van de Kolk KW,Cramer MJ,van Oosterhout MF,Doevendans PA,van der Geest RJ,Pasterkamp G,van Echteld CJ

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  • Development of an inductively coupled MR coil system for imaging and spectroscopic analysis of an implantable bioartificial construct at 11.1 T.

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    authors: Volland NA,Mareci TH,Constantinidis I,Simpson NE

    更新日期:2010-04-01 00:00:00

  • Direct CSF injection of MnCl(2) for dynamic manganese-enhanced MRI.

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  • Proton exchange rates from amino acid side chains--implications for image contrast.

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    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Liepinsh E,Otting G

    更新日期:1996-01-01 00:00:00

  • Relationships between tissue microstructure and the diffusion tensor in simulated skeletal muscle.

    abstract:PURPOSE:To establish a series of relationships defining how muscle microstructure and diffusion tensor imaging (DTI) are related. METHODS:The relationship among key microstructural features of skeletal muscle (fiber size, fibrosis, edema, and permeability) and the diffusion tensor were systematically simulated over ph...

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    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Gudino N,Griswold MA

    更新日期:2013-04-01 00:00:00

  • Comparison between simulated decoupling regimes for specific absorption rate prediction in parallel transmit MRI.

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    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Beqiri A,Hand JW,Hajnal JV,Malik SJ

    更新日期:2015-11-01 00:00:00

  • Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload.

    abstract:PURPOSE:MR-based quantification of liver magnetic susceptibility may enable field strength-independent measurement of liver iron concentration (LIC). However, susceptibility quantification is challenging, due to nonlocal effects of susceptibility on the B0 field. The purpose of this work is to demonstrate feasibility o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hernando D,Cook RJ,Diamond C,Reeder SB

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    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Wright SM,Magin RL,Kelton JR

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  • A flexible nested sodium and proton coil array with wideband matching for knee cartilage MRI at 3T.

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    pub_type: 杂志文章


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    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Wech T,Köstler H

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Bhave S,Koff MF,Sivaram Kaushik S,Potter HG,Koch KM

    更新日期:2019-08-01 00:00:00