MRI evaluation of myocardial perfusion without a contrast agent using magnetization transfer.

Abstract:

:We propose a new magnetic resonance imaging (MRI) technique that is sensitive to myocardial tissue perfusion that obviates the use of an extrinsic contrast agent. Significant advantages of such a technique are that it avoids accumulation of contrast agent when repeated studies are performed on the same subject and that it is completely noninvasive. The method makes use of a combination of magnetization transfer (MT) and T1sat (measured spin-lattice relaxation time in the presence of MT) weighting. In this Communication, we present observations from experiments with an isolated rat heart model that demonstrate increase of MT-weighted signal intensity and T1sat with flow. Also included are data showing that these effects can be made synergistic for enhancing the sensitivity to perfusion. We have observed about a 3% change in MT-weighted intensity and up to 10% change in MTT1sat-weighted intensity for a change of 1 ml/min in global flow rate.

journal_name

Magn Reson Med

authors

Prasad PV,Burstein D,Edelman RR

doi

10.1002/mrm.1910300219

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

267-70

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

30

pub_type

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