Diffusion sensitivity of 3D-GRASE in arterial spin labeling perfusion.

Abstract:

PURPOSE:To evaluate the role of true diffusion and flow-related pseudodiffusion in cerebral blood flow (CBF) quantification using arterial spin labeling (ASL) with single-shot or segmented 3D gradient and spin echo (GRASE) readouts. THEORY:The extended phase graph (EPG) algorithm, originally designed to model the effects of T1 /T2 relaxation and true diffusion in MRI acquisitions utilizing multiple refocusing RF pulses, was augmented (aEPG). This augmentation accounted for flow-related pseudodiffusion attenuation of intravascular MRI signal in the k-space domain during 3D-GRASE acquisition, which leads to blur along the partition direction in the image domain. Blurring of ASL signal into neighboring voxels can lead to underestimation of CBF in small, high-flow structures such as cortical gray matter (GM). METHODS:The diffusion sensitivity of 3D-GRASE was evaluated through aEPG simulations and in vivo experiments in 13 healthy subjects. The CBF estimation bias for different postlabeling delays, crusher gradient strengths, and segmentation factors along the partition (PAR) and phase-encoding (PE) directions was numerically assessed by simulations and experimentally validated. RESULTS:In vivo experiments demonstrated systematic underestimation of mean GM CBF measured with segmented 3D-GRASE. The GM CBF underestimation depended on ASL preparation and imaging parameters; it reached up to 25% at low-segmentation schemes (1PAR  × 2PE ) but was considerably lower at high-segmentation schemes (4PAR  × 2PE or 8PAR  × 2PE ). Theoretical predictions showed that conventional T1 /T2 relaxation and true diffusion may account for at most ∼25% of GM CBF estimation bias, whereas the pseudodiffusion effect constituted the major fraction in a typical ASL experiment. CONCLUSION:The pseudodiffusion effect leads to considerable estimation bias in ASL-based CBF quantification using 3D-GRASE readouts. This bias can be substantially reduced by increasing the segmentation factors. Magn Reson Med 80:736-747, 2018. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.

journal_name

Magn Reson Med

authors

He X,Wengler K,Schweitzer ME

doi

10.1002/mrm.27058

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

736-747

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

80

pub_type

杂志文章
  • Dehydration assessment via a portable, single sided magnetic resonance sensor.

    abstract:PURPOSE:Undiagnosed dehydration compromises health outcomes across many populations. Existing dehydration diagnostics require invasive bodily fluid sampling or are easily confounded by fluid and electrolyte intake, environment, and physical activity limiting widespread adoption. We present a portable MR sensor designed...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28004

    authors: Bashyam A,Frangieh CJ,Li M,Cima MJ

    更新日期:2020-04-01 00:00:00

  • Single-Voxel 1 H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD+ ) in humans at 7T using a 32-channel volume coil.

    abstract:PURPOSE:Reliable monitoring of tissue nicotinamide adenine dinucleotide (NAD+ ) concentration may provide insights on its roles in normal and pathological aging. In the present study, we report a 1 H MRS pulse sequence for the in vivo, localized 1 H MRS detection of NAD+ from the human brain. METHODS:Studies were carr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27971

    authors: Bagga P,Hariharan H,Wilson NE,Beer JC,Shinohara RT,Elliott MA,Baur JA,Marincola FM,Witschey WR,Haris M,Detre JA,Reddy R

    更新日期:2020-03-01 00:00:00

  • Saturated double-angle method for rapid B1+ mapping.

    abstract::For in vivo magnetic resonance imaging at high field (> or =3 T) it is essential to consider the homogeneity of the active B(1) field (B(1)+), particularly if surface coils are used for RF transmission. A new method is presented for highly rapid B(1)+ magnitude mapping. It combines the double angle method with a B(1)-...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20896

    authors: Cunningham CH,Pauly JM,Nayak KS

    更新日期:2006-06-01 00:00:00

  • Multiple inversion recovery MR subtraction imaging of human ventilation from inhalation of room air and pure oxygen.

    abstract::The feasibility of MR subtraction imaging of lung ventilation using air against oxygen using a multiple inversion recovery half-Fourier single-shot turbo spin echo (MIR-HASTE) sequence was investigated. Eight healthy, nonsmoking volunteers (3 males, 5 females; from 27 to 48 years of age) were studied on a 1.5 T MR uni...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/1522-2594(200006)43:6<913::aid-mrm21>3.0.c

    authors: Mai VM,Chen Q,Bankier AA,Edelman RR

    更新日期:2000-06-01 00:00:00

  • Electromagnetic fields of surface coil in vivo NMR at high frequencies.

    abstract::A high frequency solution of the electromagnetic field produced by a circular surface coil adjacent to a homogeneous conducting, dielectric sphere is used to predict the attainable signal to noise ratio (S/N) and specific absorption rate (SAR) for in vivo 1H NMR spectroscopy experiments from 200 to 430 MHz (4.7-10 T)....

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910220254

    authors: Keltner JR,Carlson JW,Roos MS,Wong ST,Wong TL,Budinger TF

    更新日期:1991-12-01 00:00:00

  • Lactate imaging with Hadamard-encoded slice-selective multiple quantum coherence chemical-shift imaging.

    abstract::The ability to generate in vivo maps of lactate may have significant diagnostic utility in staging and treatment planning of a wide variety of cancers. The double selective multiple quantum filter technique (SelMQC) has been shown to be effective for nonlocalized detection of lactate with little or no interference fro...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21659

    authors: Pickup S,Lee SC,Mancuso A,Glickson JD

    更新日期:2008-08-01 00:00:00

  • In vivo GABA editing using a novel doubly selective multiple quantum filter.

    abstract::A novel multiple quantum filtering method is proposed that uses a doubly selective pulse termed Delays Alternating with Nutations for Tailored Excitation (DANTE) for multiple quantum preparation. This method selectively prepares GABA-3 and GABA-4 into a multiple quantum state and suppresses all other resonances at 3.0...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10104

    authors: Shen J,Rothman DL,Brown P

    更新日期:2002-03-01 00:00:00

  • In vivo whole-blood T2 versus HbO2 calibration by modulating blood oxygenation level in the femoral vein through intermittent cuff occlusion.

    abstract:PURPOSE:To investigate the feasibility of estimating calibration constants (K and T2o ) in vivo for converting whole-blood T2 to blood hemoglobin oxygen saturation (HbO2 ) according to the Luz-Meiboom model, 1/T2=1/T2o+K(1-HbO2)2, where K and T2o are relaxivity and transverse relaxation time of fully saturated blood, r...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26885

    authors: Langham MC,Rodríguez-Soto AE,Schwartz N,Wehrli FW

    更新日期:2018-04-01 00:00:00

  • Strategy for lipid suppression in lactate imaging using STIR-DQCT: a study of hypoxic-ischemic brain injury.

    abstract::In vivo lactate detection using gradient enhanced double quantum coherence transfer (DQCT) was significantly improved by addition of short-time-inversion-recovery (STIR). Phantom studies demonstrated lipid suppression down to the background noise level with 33% loss of lactate signal. In vivo studies using a rabbit mo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910400416

    authors: Nakai T,Rhine WD,Okada T,Stevenson DK,Spielman DM

    更新日期:1998-10-01 00:00:00

  • Accurate multislice gradient echo T(1) measurement in the presence of non-ideal RF pulse shape and RF field nonuniformity.

    abstract::A methodology is presented for estimating T(1) using a two-point technique with a standard multislice gradient echo sequence. The method explicitly corrects for the shape of the RF pulse and for spatial variations in transmitted RF field intensity. Including these factors in the calculation of T(1) gives a substantial...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1112

    authors: Parker GJ,Barker GJ,Tofts PS

    更新日期:2001-05-01 00:00:00

  • Rapid in vivo musculoskeletal MR with parallel imaging at 7T.

    abstract::The purpose of this work was to implement autocalibrating GRAPPA-based parallel imaging (PI) for in vivo high-resolution (HR) MRI of cartilage and trabecular bone micro-architecture at 7T and to evaluate its performance based on comparison of MR-derived morphology metrics between accelerated and conventional images an...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21455

    authors: Banerjee S,Krug R,Carballido-Gamio J,Kelley DA,Xu D,Vigneron DB,Majumdar S

    更新日期:2008-03-01 00:00:00

  • Evidence for enhanced functional activity of cervical cord in relapsing multiple sclerosis.

    abstract::Functional MRI (fMRI) was used to assess proprioceptive-associated cervical cord activity in 24 relapsing multiple sclerosis (MS) patients and 10 controls. Cord and brain conventional and diffusion tensor (DT) MRI were also acquired. fMRI was performed using a block design during a proprioceptive stimulation consistin...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21595

    authors: Agosta F,Valsasina P,Rocca MA,Caputo D,Sala S,Judica E,Stroman PW,Filippi M

    更新日期:2008-05-01 00:00:00

  • Relationships between tissue microstructure and the diffusion tensor in simulated skeletal muscle.

    abstract:PURPOSE:To establish a series of relationships defining how muscle microstructure and diffusion tensor imaging (DTI) are related. METHODS:The relationship among key microstructural features of skeletal muscle (fiber size, fibrosis, edema, and permeability) and the diffusion tensor were systematically simulated over ph...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26993

    authors: Berry DB,Regner B,Galinsky V,Ward SR,Frank LR

    更新日期:2018-07-01 00:00:00

  • Real-time MR elastography for viscoelasticity quantification in skeletal muscle during dynamic exercises.

    abstract:PURPOSE:To develop and test real-time MR elastography for viscoelastic parameter quantification in skeletal muscle during dynamic exercises. METHODS:In 15 healthy participants, 6 groups of lower-leg muscles (tibialis anterior, tibialis posterior, peroneus, extensor digitorum longus, soleus, gastrocnemius) were investi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28095

    authors: Schrank F,Warmuth C,Görner S,Meyer T,Tzschätzsch H,Guo J,Uca YO,Elgeti T,Braun J,Sack I

    更新日期:2020-07-01 00:00:00

  • High-frequency subband compressed sensing MRI using quadruplet sampling.

    abstract:PURPOSE:To present and validate a new method that formalizes a direct link between k-space and wavelet domains to apply separate undersampling and reconstruction for high- and low-spatial-frequency k-space data. THEORY AND METHODS:High- and low-spatial-frequency regions are defined in k-space based on the separation o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24592

    authors: Sung K,Hargreaves BA

    更新日期:2013-11-01 00:00:00

  • Validation of 13C NMR measurements of liver glycogen in vivo.

    abstract::The natural abundance 13C NMR intensity of the glycogen C1 resonance was measured in the surgically exposed liver of rabbits in vivo (n = 17) by integration from 98 to 104 ppm and compared double blindedly to the subsequent biochemical measurement. Coil loading was measured each time from a reference sphere at the coi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310602

    authors: Gruetter R,Magnusson I,Rothman DL,Avison MJ,Shulman RG,Shulman GI

    更新日期:1994-06-01 00:00:00

  • Fe(III) distribution varies substantially within and between atherosclerotic plaques.

    abstract:PURPOSE:Vulnerable atherosclerotic plaques are structurally weak and prone to rupture, presumably due to local oxidative stress. Redox active iron is linked to oxidative stress and the aim of this study was to investigate the distribution of Fe(III) in carotid plaques and its relation to vulnerability for rupture. MET...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24687

    authors: Gustafsson H,Hallbeck M,Norell M,Lindgren M,Engström M,Rosén A,Zachrisson H

    更新日期:2014-02-01 00:00:00

  • Comprehensive approach for correction of motion and distortion in diffusion-weighted MRI.

    abstract::Patient motion and image distortion induced by eddy currents cause artifacts in maps of diffusion parameters computed from diffusion-weighted (DW) images. A novel and comprehensive approach to correct for spatial misalignment of DW imaging (DWI) volumes acquired with different strengths and orientations of the diffusi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10677

    authors: Rohde GK,Barnett AS,Basser PJ,Marenco S,Pierpaoli C

    更新日期:2004-01-01 00:00:00

  • Investigation of a whole-body receiver coil operating at liquid nitrogen temperatures.

    abstract::This communication describes the design and application of a receiver coil operating at liquid nitrogen temperature and intended as a surface coil in a whole-body imager. Its particular application is seen as the external receiver for parasitic internal or implanted detectors. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910070211

    authors: Hall AS,Barnard B,McArthur P,Gilderdale DJ,Young IR,Bydder GM

    更新日期:1988-06-01 00:00:00

  • Novel pH-sensitive paramagnetic liposomes with improved MR properties.

    abstract::The use of paramagnetic pH-sensitive liposomes was recently suggested as a new approach for monitoring pathologic changes in pH by MRI. Such liposomes must be stable in blood and selectively release the encapsulated paramagnetic agent when exposed to lower pH in the target tissue. In the present study, different lipos...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20009

    authors: Løkling KE,Skurtveit R,Bjørnerud A,Fossheim SL

    更新日期:2004-04-01 00:00:00

  • A fuse for magnetic resonance imaging probes.

    abstract::In a research environment, a magnetic resonance imaging system's manufacturer-supplied protection against excessive rf power deposition in the sample is often compromised. This paper presents a widely applicable scheme, based on a commonly available fuse, that simply and effectively limits the average rf power into a ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910090213

    authors: Hedges LK

    更新日期:1989-02-01 00:00:00

  • Robust water fat separated dual-echo MRI by phase-sensitive reconstruction.

    abstract:PURPOSE:The purpose of this work was to develop and evaluate a robust water-fat separation method for T1-weighted symmetric two-point Dixon data. THEORY AND METHODS:A method for water-fat separation by phase unwrapping of the opposite-phase images by phase-sensitive reconstruction (PSR) is introduced. PSR consists of ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26488

    authors: Romu T,Dahlström N,Leinhard OD,Borga M

    更新日期:2017-09-01 00:00:00

  • Quantification of punctate iron sources using magnetic resonance phase.

    abstract::Iron-mediated tissue damage is present in cerebrovascular and neurodegenerative diseases and neurotrauma. Brain microbleeds are often present in these maladies and are assuming increasing clinical importance. Because brain microbleeds present a source of pathologic iron to the brain, the noninvasive quantification of ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22185

    authors: McAuley G,Schrag M,Sipos P,Sun SW,Obenaus A,Neelavalli J,Haacke EM,Holshouser B,Madácsi R,Kirsch W

    更新日期:2010-01-01 00:00:00

  • The MR tomograph as a sound generator: fMRI tool for the investigation of the auditory cortex.

    abstract::An automatic fMRI protocol for the investigation of the human auditory cortex has been developed. For the activation of the auditory system, the scanner noise itself is the source of sound. Rapid switching of B0 gradients allows the generation of tones of defined frequencies and amplitude on a conventional scanner wit...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910400621

    authors: Bilecen D,Radü EW,Scheffler K

    更新日期:1998-12-01 00:00:00

  • Validation of a new T2* algorithm and its uncertainty value for cardiac and liver iron load determination from MRI magnitude images.

    abstract:PURPOSE:To validate an automatic algorithm for offline T2* measurements, providing robust, vendor-independent T2*, and uncertainty estimates for iron load quantification in the heart and liver using clinically available imaging sequences. METHODS:A T2* region of interest (ROI)-based algorithm was developed for robustn...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25767

    authors: Bidhult S,Xanthis CG,Liljekvist LL,Greil G,Nagel E,Aletras AH,Heiberg E,Hedström E

    更新日期:2016-04-01 00:00:00

  • Mechanisms of proton spin dephasing in a system of magnetic particles.

    abstract::For protons diffusing among a system of magnetic particles, the process by which initial phase coherence is lost depends substantially on particle size. In this article, evidence for three dephasing mechanisms is presented: an incremental process at small particle sizes (motional averaging regime), a discrete process ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22966

    authors: de Haan HW

    更新日期:2011-12-01 00:00:00

  • A PRESTO-SENSE sequence with alternating partial-Fourier encoding for rapid susceptibility-weighted 3D MRI time series.

    abstract::A 3D sequence for dynamic susceptibility imaging is proposed which combines echo-shifting principles (such as PRESTO), sensitivity encoding (SENSE), and partial-Fourier acquisition. The method uses a moderate SENSE factor of 2 and takes advantage of an alternating partial k-space acquisition in the "slow" phase encode...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10599

    authors: Klarhöfer M,Dilharreguy B,van Gelderen P,Moonen CT

    更新日期:2003-10-01 00:00:00

  • Contrast-enhanced MRI of brown adipose tissue after pharmacological stimulation.

    abstract::A non-invasive method for studying the modifications induced in lipid depots by hormonal stimulation could extend knowledge of adipose tissues. We studied the effect of adrenergic stimulation on interscapular brown adipose tissue (IBAT) of rats using contrast-enhanced MRI. Controls and rats pre-treated with adrenaline...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20851

    authors: Sbarbati A,Cavallini I,Marzola P,Nicolato E,Osculati F

    更新日期:2006-04-01 00:00:00

  • Fast mapping of myocardial blood flow with MR first-pass perfusion imaging.

    abstract::Accurate and fast quantification of myocardial blood flow (MBF) with MR first-pass perfusion imaging techniques on a pixel-by-pixel basis remains difficult due to relatively long calculation times and noise-sensitive algorithms. In this study, Zierler's central volume principle was used to develop an algorithm for the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21559

    authors: Goldstein TA,Jerosch-Herold M,Misselwitz B,Zhang H,Gropler RJ,Zheng J

    更新日期:2008-06-01 00:00:00

  • NMR investigation of hydroxyethyl starch-induced aggregation of human erythrocytes.

    abstract::Aggregation of human erythrocytes at physiological hematocrit by hydroxyethyl starch (HES) was investigated with a 1H nuclear magnetic resonance method which measures the erythrocyte mean water exchange time, tau a. A relationship that takes into account the effect of the aggregate as the water-exchanging unit was use...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910050108

    authors: Caines GH,Goldstein JH

    更新日期:1987-07-01 00:00:00