Abstract:
PURPOSE:Nicotinamide adenine dinucleotide (NAD), in oxidized (NAD(+) ) or reduced (NADH) form, plays key roles in cellular metabolism. Intracellular NAD(+) /NADH ratio represents the cellular redox state; however, it is difficult to measure in vivo. We report here a novel in vivo (31) P MRS method for noninvasive measurement of intracellular NAD concentrations and NAD(+) /NADH ratio in the brain. METHODS:It uses a theoretical model to describe the NAD spectral patterns at a given field for quantification. Standard NAD solutions and independent cat brain measurements at 9.4 T and 16.4 T were used to evaluate this method. We also measured T1 values of brain NAD. RESULTS:Model simulation and studies of solutions and brains indicate that the proposed method can quantify submillimolar NAD concentrations with reasonable accuracy if adequate (31) P MRS signal-to-noise ratio and linewidth were obtained. The NAD concentrations and NAD(+) /NADH ratio of cat brains measured at 16.4 T and 9.4 T were consistent despite the significantly different T1 values and NAD spectra patterns at two fields. CONCLUSION:This newly established (31) P MRS method makes it possible for the first time to noninvasively study the intracellular redox state and its roles in brain functions and diseases, and it can potentially be applied to other organs.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Lu M,Zhu XH,Zhang Y,Chen Wdoi
10.1002/mrm.24859subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1959-72issue
6eissn
0740-3194issn
1522-2594journal_volume
71pub_type
杂志文章abstract::IVIM MR imaging is a method which generates images of diffusion and perfusion in vivo. Until now, intravoxel incoherent motion (IVIM) images have been obtained using spin-echo sequences with extragradient pulses, resulting in long acquisition times (typically 2 x 8 min 32 s). A new method is proposed here, using stead...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910070312
更新日期:1988-07-01 00:00:00
abstract::The concept of temporal echo multiplexing is defined and used to develop rapid biphasic spin-echo sequences for imaging the heart. Three imaging sequences, based on four-echo and two-echo multiplexing and rapid single echo (i.e., conventional spin-echo imaging), are compared. Preliminary results indicate that two-echo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910110109
更新日期:1989-07-01 00:00:00
abstract::The remarkable success of magnetic resonance imaging of adult brain relates to the unusually large ratio of the longitudinal relaxation rates 1/T1 of white and gray matter, approximately 2:1 at physiological temperature and traditional imaging fields. Several investigators have conjectured that myelin is the source of...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910140306
更新日期:1990-06-01 00:00:00
abstract::Velocity-encoded phase contrast imaging is being used increasingly in clinical imaging for quantization of blood flow. In this study, the accuracy and precision of ascending aorta flow measurements were found to depend on several subtle aspects of the scan prescription and image analysis. While the usual scan paramete...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910260115
更新日期:1992-07-01 00:00:00
abstract::Parallel transmission has emerged as an efficient means for implementing multidimensional spatially selective radiofrequency excitation pulses. To date, most theoretical and experimental work on parallel transmission radiofrequency (RF) pulse design is based on the small-tip-angle approximation to the Bloch equation. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22827
更新日期:2011-09-01 00:00:00
abstract::Quantitative artificial neural network analysis for 1550 ex vivo 31P nuclear magnetic resonance spectra from hypothermically reperfused pig livers was assessed. These spectra show wide ranges of metabolite concentrations and have been analyzed using metabolite prior knowledge based lineshape fitting analysis which had...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910380522
更新日期:1997-11-01 00:00:00
abstract::SENSitivity Encoding (SENSE) greatly enhances the quality of diffusion-weighted echo-planar imaging (EPI) by reducing blurring and off-resonance artifacts. Such improvement would also be desirable for diffusion tensor imaging (DTI), but measures derived from the diffusion tensor can be extremely sensitive to any kind ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10184
更新日期:2002-07-01 00:00:00
abstract:PURPOSE:This study aims to (i) develop a new high-speed MRI approach by implementing correlation imaging in wavelet-space, and (ii) demonstrate the ability of wavelet-space correlation imaging to image human anatomy with involuntary or physiological motion. METHODS:Correlation imaging is a high-speed MRI framework in ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25546
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:An increasing number of studies show that magnetic susceptibility in white matter fibers is anisotropic and may be described by a tensor. However, the limited head rotation possible for in vivo human studies leads to an ill-conditioned inverse problem in susceptibility tensor imaging (STI). Here we suggest the ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25322
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To design, evaluate, and apply a bow tie antenna transceiver radiofrequency (RF) coil array tailored for cardiac MRI at 7.0 Tesla (T). METHODS:The radiofrequency (RF) coil array comprises 16 building blocks each containing a bow tie shaped λ/2-dipole antenna. Numerical simulations were used for transmission fi...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25840
更新日期:2016-06-01 00:00:00
abstract::Cortical bone in the mature skeleton has a short T(2)* and produces no detectable signal with conventional MR sequences. A two-dimensional ultrashort echo time (UTE) sequence employing half radio frequency (RF) pulse excitations and radial ramp sampling reduces the effective TE to 8 micros and is capable of detecting ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21397
更新日期:2007-11-01 00:00:00
abstract::We applied MRI to the in vivo detection of spontaneous colorectal tumors in a unique mouse model, the Fox Chase Cancer Center (FCCC) ApcMIN mouse. Unlike other Min (multiple intestinal neoplasia) strains, FCCC ApcMIN animals develop an appreciable number of tumors in the large intestine, which makes them an appropriat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20175
更新日期:2004-09-01 00:00:00
abstract::The chemical shift of water and fat resonances in proton MRI allows separation of water and fat signal from chemical shift encoded data. This work describes an automatic method that produces separate water and fat images as well as quantitative maps of fat signal fraction and T2* from complex multiecho gradient-recall...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.23185
更新日期:2012-06-01 00:00:00
abstract::Fluid-attenuated inversion recovery (FLAIR) images obtained during the administration of supplemental oxygen demonstrate a hyperintense signal within the cerebrospinal fluid (CSF) that is likely caused by T1 changes induced by paramagnetic molecular oxygen. Previous studies demonstrated a linear relationship between t...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/mrm.20546
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:To illustrate the potential bias caused by imaging gradients in correlation MRI sequences using longitudinal magnetization storage (LS) and examine the case of filter exchange imaging (FEXI) yielding maps of the apparent exchange rate (AXR). METHODS:The effects of imaging gradients in FEXI were observed on yea...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26856
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:To use quantitative susceptibility mapping (QSM) to investigate changes in cartilage canals in the distal femur of juvenile goats after their surgical transection. METHODS:Chondronecrosis was surgically induced in the right medial femoral condyles of four 4-day-old goats. Both the operated and control knees we...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26214
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:To obtain three-dimensional (3D) MR angiography having high contrast between vessel and stationary background tissue, a novel technique called sliding time of flight (TOF) is proposed. METHODS:The proposed method relies on the property that flow-related enhancement (FRE) is maximized at the blood-entering slic...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25215
更新日期:2015-03-01 00:00:00
abstract::Optimization of experimental settings of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), like the contrast administration protocol, is of great importance for reliable quantification of the microcirculatory properties, such as the volume transfer-constant K(trans). Using system identification theory an...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21575
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:To develop a new parallel transmit (pTx) pulse design for simultaneous multiband (MB) excitation in order to tackle simultaneously the problems of transmit B1 (B1+) inhomogeneity and total radiofrequency (RF) power, so as to allow for optimal RF excitation when using MB pulses for slice acceleration for high an...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24828
更新日期:2013-09-01 00:00:00
abstract::A new approach to spin-echo imaging is presented in which the 180 degrees RF pulse refocuses two or more spin-echoes at different positions in the readout period. When simultaneous echo refocusing (SER) is implemented using multiple 180 degrees pulses, an undesirable mixing of stimulated echoes and primary echoes from...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20587
更新日期:2005-09-01 00:00:00
abstract:PURPOSE:Oscillating gradient spin-echo (OGSE) diffusion MRI provides information about the microstructure of biological tissues by means of the frequency dependence of the apparent diffusion coefficient (ADC). ADC dependence on OGSE frequency has been explored in numerous rodent studies, but applications in the human b...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28083
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:Real-time assessment of ventricular volumes requires high acceleration factors. Residual convolutional neural networks (CNN) have shown potential for removing artifacts caused by data undersampling. In this study, we investigated the ability of CNNs to reconstruct highly accelerated radial real-time data in pat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27480
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:We demonstrate the feasibility of MRI with missing-pulse steady-state free precession (MP-SSFP) in a 4T magnet with artificially degraded homogeneity. METHODS:T1 , T2 , and diffusion contrast of MP-SSFP was simulated with constant and alternate radiofrequency (RF) phase using an extended phase graph. To valida...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28469
更新日期:2021-02-01 00:00:00
abstract::This work helps elucidate how background noise introduces statistical artifacts in the distribution of the sorted eigenvalues and eigenvectors in diffusion tensor MRI (DT-MRI) data. Although it was known that sorting eigenvalues (principal diffusivities) by magnitude introduces a bias in their sample mean within a hom...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200007)44:1<41::aid-mrm8>3.0.co;
更新日期:2000-07-01 00:00:00
abstract::Adipose tissue as well as other depots of fat (triglycerides) are increasingly being recognized as active contributors to the human function and metabolism. In addition to the fat concentration, also the fatty acid chemical composition (FAC) of the triglyceride molecules may play an important part in diseases such as ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章,评审
doi:10.1002/mrm.28471
更新日期:2021-01-01 00:00:00
abstract::Nonlinear feedback interactions have been shown to amplify contrast due to small differences in resonance frequency arising from microscopic susceptibility variations. Determining whether the selectivity of feedback-based contrast enhancement for small resonance frequency variations remains valid even in the presence ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21584
更新日期:2009-04-01 00:00:00
abstract::Functional MRI (fMRI) was used to assess proprioceptive-associated cervical cord activity in 24 relapsing multiple sclerosis (MS) patients and 10 controls. Cord and brain conventional and diffusion tensor (DT) MRI were also acquired. fMRI was performed using a block design during a proprioceptive stimulation consistin...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21595
更新日期:2008-05-01 00:00:00
abstract::Continuously moving table (CMT) MRI is a new method that is capable of generating 3D, seamless, large field-of-view (FOV) images by acquiring readouts along the patient superior-inferior axis as the subject is translated through the scanner. For applications that require artifact-free images, such as arterial-phase co...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20848
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:To optimize 3D radial ultrashort echo time MRI for high resolution whole-lung imaging. METHODS:3D radial ultrashort echo time was implemented on a 3T scanner to investigate the effects of: (1) limited field-of-view excitation, (2) variable density readouts, and (3) radial oversampling. Improvements in noise pe...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24570
更新日期:2013-11-01 00:00:00
abstract::In this work, substrate selection was monitored in the left ventricle of the canine myocardium by following pyruvate and lactate oxidation under in vivo conditions at basal and elevated workloads. These studies were conducted in the open chest model using dynamic 13C NMR techniques in the presence and absence of dichl...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910380608
更新日期:1997-12-01 00:00:00