Abstract:
PURPOSE:To use quantitative susceptibility mapping (QSM) to investigate changes in cartilage canals in the distal femur of juvenile goats after their surgical transection. METHODS:Chondronecrosis was surgically induced in the right medial femoral condyles of four 4-day-old goats. Both the operated and control knees were harvested at 2, 3, 5, and 10 weeks after the surgeries. Ex vivo MRI scans were conducted at 9.4 Tesla using TRAFF (relaxation time along a fictitious field)-weighted fast spin echo imaging and QSM to detect areas of chondronecrosis and investigate cartilage canal abnormalities. Histological sections from these same areas stained with hematoxylin and eosin and safranin O were evaluated to assess the affected tissues. RESULTS:Both the histological sections and the TRAFF -weighted images of the femoral condyles demonstrated focal areas of chondronecrosis, evidenced by pyknotic chondrocyte nuclei, loss of matrix staining, and altered MR image contrast. At increasing time points after surgery, progressive changes and eventual disappearance of abnormal cartilage canals were observed in areas of chondronecrosis by using QSM. CONCLUSION:Abnormal cartilage canals were directly visualized in areas of surgically induced chondronecrosis. Quantitative susceptibility mapping enabled investigation of the vascular changes accompanying chondronecrosis in juvenile goats. Magn Reson Med 77:1276-1283, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Wang L,Nissi MJ,Toth F,Johnson CP,Garwood M,Carlson CS,Ellermann Jdoi
10.1002/mrm.26214subject
Has Abstractpub_date
2017-03-01 00:00:00pages
1276-1283issue
3eissn
0740-3194issn
1522-2594journal_volume
77pub_type
杂志文章abstract::The resolution and homogeneity limitations of echo-planar imaging (EPI) are overcome by zoom imaging of an easily shimmed localized volume. Use of the stimulated echo enables single-shot localization. In vivo 0.5-mm resolution EPI images of selected regions of a cat brain at 4.7 T are presented. ...
journal_title:Magnetic resonance in medicine
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