Spectroscopic imaging of glutamate C4 turnover in human brain.

Abstract:

:One-dimensional spectroscopic imaging of (13)C-4-glutamate turnover is performed in the human brain with a 6 cc nominal voxel resolution at 4T. Data were acquired with an indirect detection approach using a short spin echo single quantum (1)H-(13)C heteronuclear editing method and a 7 cm surface coil with quadrature (13)C decoupling coils. To analyze the data as a function of tissue type, T(1)-based image segmentation through the surface coil was performed to determine the gray and white matter contributions to each voxel. The tricarboxylic acid (TCA) cycle rate in gray and white matter was then determined using a two-compartment model with the tissue fractionation derived from the image segmentation. The mean values for the TCA cycle rate for occipital gray and white matter from three volunteers was 0.88 +/- 0.12 and 0.28 +/- 0.13 respectively, in agreement with literature data.

journal_name

Magn Reson Med

authors

Pan JW,Stein DT,Telang F,Lee JH,Shen J,Brown P,Cline G,Mason GF,Shulman GI,Rothman DL,Hetherington HP

doi

10.1002/1522-2594(200011)44:5<673::aid-mrm3>3.0.co

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

673-9

issue

5

eissn

0740-3194

issn

1522-2594

pii

10.1002/1522-2594(200011)44:5<673::AID-MRM3>3.0.CO

journal_volume

44

pub_type

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