Measuring extracellular volume fraction by MRI: First verification of values given by clinical sequences.

Abstract:

PURPOSE:To verify MR measurements of myocardial extracellular volume fraction (ECV) based on clinically applicable T1-mapping sequences against ECV measurements by radioisotope tracer in pigs and to relate the results to those obtained in volunteers. METHODS:Between May 2016 and March 2017, 8 volunteers (25 ± 4 years, 3 female) and 8 pigs (4 female) underwent ECV assessment with SASHA, MOLLI5(3b)3, MOLLI5(3s)3, and MOLLI5s(3s)3s. Myocardial ECV was measured independently in pigs using a radioisotope tracer method. RESULTS:In pigs, ECV in normal myocardium was not different between radioisotope (average ± standard deviation; 19 ± 2%) and SASHA (21 ± 2%; P = 0.086). ECV was higher by MOLLI5(3b)3 (26 ± 2%), MOLLI5(3s)3 (25 ± 2%), and MOLLI5s(3s)3s (25 ± 2%) compared with SASHA or radioisotope (P ≤ 0.001 for all). ECV in volunteers was higher by MOLLI5(3b)3 (26 ± 3%) and MOLLI5(3s)3 (26 ± 3%) than by SASHA (22 ± 3%; P = 0.022 and P = 0.033). No difference was found between MOLLI5s(3s)3s (25 ± 3%) and SASHA (P = 0.225). Native T1 of blood and myocardium as well as postcontrast T1 of myocardium was consistently lower using MOLLI compared with SASHA. ECV increased over time as measured by MOLLI5(3b)3 and MOLLI5(3s)3 for pigs (0.08% and 0.07%/min; P = 0.004 and P = 0.013) and by MOLLI5s(3s)3s for volunteers (0.07%/min; P = 0.032) but did not increase as measured by SASHA. CONCLUSION:Clinically available MOLLI and SASHA techniques can be used to accurately estimate ECV in normal myocardium where MOLLI-sequences show minor overestimation driven by underestimation of postcontrast T1 when compared with SASHA. The timing of imaging after contrast administration affected the measurement of ECV using some variants of the MOLLI sequence.

journal_name

Magn Reson Med

authors

Nordlund D,Xanthis C,Bidhult S,Jablonowski R,Kanski M,Kopic S,Carlsson M,Engblom H,Aletras AH,Arheden H

doi

10.1002/mrm.27938

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

662-672

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

83

pub_type

杂志文章
  • 3D-printed Shepp-Logan phantom as a real-world benchmark for MRI.

    abstract:PURPOSE:As prescribed and reliable geometrical entities, phantoms have served as indispensable validation tools in a variety of MR-related topics. Though a number of phantoms have been conceived, certain applications may warrant highly customized geometries. The purpose of this study was to demonstrate the expediency o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25593

    authors: Kasten JA,Vetterli T,Lazeyras F,Van De Ville D

    更新日期:2016-01-01 00:00:00

  • Pharmacological MRI of the choroid and retina: blood flow and BOLD responses during nitroprusside infusion.

    abstract::Nitroprusside, a vasodilatory nitric oxide donor, is clinically used during vascular surgery and to lower blood pressure in acute hypertension. This article reports a novel application of blood flow (BF) and blood oxygenation level dependent (BOLD) MRI on an 11.7T scanner to image the rat chorioretinal BF and BOLD cha...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24112

    authors: Shih YY,Li G,Muir ER,De La Garza BH,Kiel JW,Duong TQ

    更新日期:2012-10-01 00:00:00

  • Aldehyde fixative solutions alter the water relaxation and diffusion properties of nervous tissue.

    abstract::Chemically-fixed nervous tissues are well-suited for high-resolution, time-intensive MRI acquisitions without motion artifacts, such as those required for brain atlas projects, but the aldehyde fixatives used may significantly alter tissue MRI properties. To test this hypothesis, this study characterized the impact of...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21977

    authors: Shepherd TM,Thelwall PE,Stanisz GJ,Blackband SJ

    更新日期:2009-07-01 00:00:00

  • Differentiation between cortical atrophy and hydrocephalus using 1H MRS.

    abstract::Quantitative 1H MRS to determine cerebral metabolite patterns and MRI to determine CSF flow were applied to 12 patients with ventricular dilation-Group A, cortical atrophy (N = 5); or Group B, hydrocephalus (N = 7)- and in 9 normal controls. While mean brain water (Group A = 80% +/- 6; Group B = 86% +/- 5; normal = 85...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910370317

    authors: Bluml S,McComb JG,Ross BD

    更新日期:1997-03-01 00:00:00

  • In vivo quantitative three-dimensional motion mapping of the murine myocardium with PC-MRI at 17.6 T.

    abstract::This work presents a method that allows for the assessment of 3D murine myocardial motion in vivo at microscopic resolution. Phase-contrast (PC) magnetic resonance imaging (MRI) at 17.6 T was applied to map myocardial motion in healthy mice along three gradient directions. High-resolution velocity maps were acquired a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20866

    authors: Herold V,Mörchel P,Faber C,Rommel E,Haase A,Jakob PM

    更新日期:2006-05-01 00:00:00

  • Results for diffusion-weighted imaging with a fourth-channel gradient insert.

    abstract::Diffusion-weighted imaging suffers from motion artifacts and relatively low signal quality due to the long echo times required to permit the diffusion encoding. We investigated the inclusion of a noncylindrical fourth gradient coil, dedicated entirely to diffusion encoding, into the imaging system. Standard three-axis...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22971

    authors: Feldman RE,Scholl TJ,Alford JK,Handler WB,Harris CT,Chronik BA

    更新日期:2011-12-01 00:00:00

  • Self-calibrating parallel imaging with automatic coil sensitivity extraction.

    abstract::Calibration of the spatial sensitivity functions of coil arrays is a crucial element in parallel magnetic resonance imaging (PMRI). The most common approach has been to measure coil sensitivities directly using one or more low-resolution images acquired before or after accelerated data acquisition. However, since it i...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10087

    authors: McKenzie CA,Yeh EN,Ohliger MA,Price MD,Sodickson DK

    更新日期:2002-03-01 00:00:00

  • Correction of phase errors in quantitative water-fat imaging using a monopolar time-interleaved multi-echo gradient echo sequence.

    abstract:PURPOSE:To propose a phase error correction scheme for monopolar time-interleaved multi-echo gradient echo water-fat imaging that allows accurate and robust complex-based quantification of the proton density fat fraction (PDFF). METHODS:A three-step phase correction scheme is proposed to address a) a phase term induce...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26485

    authors: Ruschke S,Eggers H,Kooijman H,Diefenbach MN,Baum T,Haase A,Rummeny EJ,Hu HH,Karampinos DC

    更新日期:2017-09-01 00:00:00

  • Potassium transport in Langendorff-perfused mouse hearts assessed by 87Rb NMR spectroscopy.

    abstract::We studied the fluxes of a potassium congener (Rb(+)) in mouse hearts by (87)Rb MRS at 8.4T. The hearts were loaded with Rb(+) by perfusion with Krebs-Henseleit buffer, in which 50% of K(+) was substituted with Rb(+). We initiated Rb(+) efflux by changing the perfusion medium to Rb(+)-free buffer. Spectra were acquire...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20450

    authors: Jilkina O,Xiang B,Kuzio B,Rendell J,Kupriyanov VV

    更新日期:2005-05-01 00:00:00

  • A numerical approach to non-circular birdcage RF coil optimization: verification with a fourth-order coil.

    abstract::It is demonstrated that birdcage resonators, satisfying conditions of quadrature operation and radiofrequency field homogeneity, can be realized in practice on formers of non-circular cross section described by an equation of the form (x/a)n + (y/b)n = 1 where a and b are constants and n > or = 2 is an integer. Using ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199906)41:6<1180::aid-mrm1

    authors: Riauka TA,De Zanche NF,Thompson R,Vermeulen FE,Capjack CE,Allen PS

    更新日期:1999-06-01 00:00:00

  • A fast, analytically based method to optimize local transmit efficiency for a transmit array.

    abstract:PURPOSE:To develop an analytically based algorithm for rapid optimization of the local radiofrequency magnetic (B1+) field intensity for a given radiofrequency power through a transmit array. The analytical nature of the method will yield insight to optimization requirements and provides a valuable reference for numeri...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24653

    authors: Carluccio G,Collins CM,Erricolo D

    更新日期:2014-01-01 00:00:00

  • Evaluation of coils for imaging histological slides: signal-to-noise ratio and filling factor.

    abstract:PURPOSE:To investigate the relative gain in sensitivity of five histology coils designed in-house to accommodate tissue sections of various sizes and compare with commercial mouse head coils. METHODS:The coil set was tailored to house tissue sections ranging from 5 to1000 µm encased in either glass slides or coverslip...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24841

    authors: Hoang DM,Voura EB,Zhang C,Fakri-Bouchet L,Wadghiri YZ

    更新日期:2014-05-01 00:00:00

  • High-order coils as transmitters for NMR imaging.

    abstract::High-order radiofrequency transmitter coils are described that permit, in the context of NMR imaging, a knowledgeable trade-off between coil complexity and the degree of inhomogeneity over a specified volume of space. A mathematical formulation of high-order coils is developed for an axially symmetric polarizing dc fi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910030108

    authors: Sotgiu A,Hyde JS

    更新日期:1986-02-01 00:00:00

  • Unambiguous assignment of the H3S and H3R deuterations of cerebral (2-13C) glutamate by 13C NMR at 18.8 Tesla.

    abstract::We used high-field (13)C NMR (18.8 T) to assign unambiguously the isotopic shifts induced by the deuterium substitutions of the H3(proR) and H3(proS) hydrogens of (2-(13)C) glutamate in extracts of the brain from deuterated animals. Monodeuterated H3R or H3S glutamate diastereoisomers were produced stereospecifically ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22277

    authors: Rodrigues TB,Violante IR,Cerdán S

    更新日期:2010-04-01 00:00:00

  • Echo-planar spin-echo and inversion pulses.

    abstract::The echo-planar k-space trajectory can be used as the basis for any two-dimensional selective pulse. The main application is spectral-spatial pulses, which must be based on the echo-planar trajectory. In this paper we show how echo-planar spin-echo (EPSE) pulses may be designed. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290609

    authors: Pauly J,Spielman D,Macovski A

    更新日期:1993-06-01 00:00:00

  • Sampling errors in projection reconstruction MRI.

    abstract::Certain kinds of artifacts have been reported when projection reconstruction (PR) techniques are used in magnetic resonance imaging (MRI). These will occur if the spacing between samples in k-space is too large. It has been suggested that PR requires finer k-space sampling than does two-dimensional Fourier reconstruct...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910400317

    authors: Joseph PM

    更新日期:1998-09-01 00:00:00

  • Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRI.

    abstract::Simulations of dynamic susceptibility contrast (DSC) MRI are frequently performed by assuming a certain shape for the input function and the microvascular response function. However, to investigate the influence of parameters that will affect the shape of the input function, a more complex model of the human vasculatu...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10567

    authors: van Osch MJ,Vonken EJ,Wu O,Viergever MA,van der Grond J,Bakker CJ

    更新日期:2003-09-01 00:00:00

  • Comprehensive quantification of signal-to-noise ratio and g-factor for image-based and k-space-based parallel imaging reconstructions.

    abstract::Parallel imaging reconstructions result in spatially varying noise amplification characterized by the g-factor, precluding conventional measurements of noise from the final image. A simple Monte Carlo based method is proposed for all linear image reconstruction algorithms, which allows measurement of signal-to-noise r...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21728

    authors: Robson PM,Grant AK,Madhuranthakam AJ,Lattanzi R,Sodickson DK,McKenzie CA

    更新日期:2008-10-01 00:00:00

  • Continuously moving table MRI with golden angle radial sampling.

    abstract:PURPOSE:Continuously moving table (CMT) MRI is a high throughput technique that has multiple applications in whole-body imaging. In this work, CMT MRI based on golden angle (GA, 111.246° azimuthal step) radial sampling is developed at 3 Tesla (T), with the goal of increased flexibility in image reconstruction using arb...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25531

    authors: Sengupta S,Smith DS,Welch EB

    更新日期:2015-12-01 00:00:00

  • High-resolution slice-selective Fourier velocity encoding in congenital heart disease using spiral SENSE with velocity unwrap.

    abstract::Quantification of peak velocity is important in the assessment of stenotic flow jets in patients with congenital heart disease. Phase-contrast magnetic resonance underestimates peak velocities. Hence, clinically Doppler ultrasound is used as the reference standard for assessing stenoses. It is possible to accurately m...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24293

    authors: Steeden JA,Jones A,Pandya B,Atkinson D,Taylor AM,Muthurangu V

    更新日期:2012-06-01 00:00:00

  • RAPID--a new method for fast imaging using a single slice of Z-magnetization.

    abstract::A single slice of z-magnetization is used to generate high-speed images. The slice selection step is achieved using two sin-sinc pulses. This procedure eliminates the need for continual slice gradient reversal, a requirement for the FLASH technique. The RAPID imaging method has less inherent T1 and/or T2 dependence th...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910050213

    authors: Brooks WM,Brereton IM,Doddrell DM

    更新日期:1987-08-01 00:00:00

  • Comparison of k-space sampling schemes for multidimensional MR spectroscopic imaging.

    abstract::For clinical 31P MR spectroscopic imaging (MRSI) studies, where signal averaging is necessary, some improvement of sensitivity and spatial response function may be achieved by acquiring data over a spherical k-space volume and varying the number of averages acquired in proportion to the desired spatial filter. Eight d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360321

    authors: Hugg JW,Maudsley AA,Weiner MW,Matson GB

    更新日期:1996-09-01 00:00:00

  • Cerebral glucose is detectable by localized proton NMR spectroscopy in normal rat brain in vivo.

    abstract::This contribution reports the first direct and noninvasive observation of cerebral glucose in normal anesthetized rats (n = 16) using short-echo-time localized proton NMR spectroscopy (2.35 T, STEAM, TR = 6000 ms, TE = 20 ms, 125 microliters). In addition to resonances from N-acetyl aspartate (NAA), glutamate, total c...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910190243

    authors: Gyngell ML,Michaelis T,Hörstermann D,Bruhn H,Hänicke W,Merboldt KD,Frahm J

    更新日期:1991-06-01 00:00:00

  • FLAIR imaging using nonselective inversion pulses combined with slice excitation order cycling and k-space reordering to reduce flow artifacts.

    abstract::High-signal artifacts produced by cerebrospinal fluid (CSF) flow can adversely affect fluid-attenuated inversion recovery (FLAIR) imaging of the brain and spinal cord. This study explores the use of a nonslice-selective inversion pulse to eliminate CSF flow artifacts together with a technique called "K-space Reordered...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1198

    authors: Herlihy AH,Oatridge A,Curati WL,Puri BK,Bydder GM,Hajnal JV

    更新日期:2001-08-01 00:00:00

  • Apparent diffusion of water, ions, and small molecules in the Xenopus oocyte is consistent with Brownian displacement.

    abstract::The incoherent displacement of water in living tissues is of considerable interest because of the widespread use of diffusion-weighted MRI, for which image contrast is based on the water apparent diffusion coefficient (ADC). It has been hypothesized that the decrease in water ADC associated with brain injury is primar...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10181

    authors: Sehy JV,Ackerman JJ,Neil JJ

    更新日期:2002-07-01 00:00:00

  • Gradient, high-resolution, magic-angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue.

    abstract::The recently developed technique of gradient, high-resolution magic-angle spinning NMR (g-hr-MAS-NMR) spectroscopy was applied to the study of ex vivo human lipoma and liposarcoma tissue. Compared with conventional 1H-NMR, the g-hr-MAS method yielded a large improvement in spectral resolution and permitted the detecti...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910380307

    authors: Millis KK,Maas WE,Cory DG,Singer S

    更新日期:1997-09-01 00:00:00

  • Continuous assessment of relative cerebral blood volume in transient ischemia using steady state susceptibility-contrast MRI.

    abstract::The utility of a noninvasive steady state susceptibility-contrast MRI technique for continuous measurement of relative cerebral blood volume (rCBV) during global transient ischemia and subsequent hyperemia in a feline ischemia model is demonstrated. The measurements were obtained during a 10-min period of occlusion an...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910350207

    authors: Hamberg LM,Boccalini P,Stranjalis G,Hunter GJ,Huang Z,Halpern E,Weisskoff RM,Moskowitz MA,Rosen BR

    更新日期:1996-02-01 00:00:00

  • T1 measurements in the human myocardium: the effects of magnetization transfer on the SASHA and MOLLI sequences.

    abstract:PURPOSE:Quantitative mapping of the native T1 of the heart using the modified look-locker inversion recovery (MOLLI) technique provides high quality diagnostic information without requiring contrast agents. Previous work has considered the effects of T2 relaxation on MOLLI T1 measurements, finding that the T1 measured ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24867

    authors: Robson MD,Piechnik SK,Tunnicliffe EM,Neubauer S

    更新日期:2013-09-01 00:00:00

  • Improved MUSSELS reconstruction for high-resolution multi-shot diffusion weighted imaging.

    abstract:PURPOSE:MUSSELS is a one-step iterative reconstruction method for multishot diffusion weighted (msDW) imaging. The current work presents an efficient implementation, termed IRLS MUSSELS, that enables faster reconstruction to enhance its utility for high-resolution diffusion MRI studies. METHODS:The recently proposed M...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28090

    authors: Mani M,Aggarwal HK,Magnotta V,Jacob M

    更新日期:2020-06-01 00:00:00

  • Real-time dynamic frequency and shim correction for single-voxel magnetic resonance spectroscopy.

    abstract::Subject motion during brain magnetic resonance spectroscopy acquisitions generally reduces the magnetic field (B₀) homogeneity across the volume of interest or voxel. This is the case even if prospective motion correction ensures that the voxel follows the head. We introduce a novel method for rapidly mapping linear v...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24129

    authors: Keating B,Ernst T

    更新日期:2012-11-01 00:00:00