Abstract:
:The utility of a noninvasive steady state susceptibility-contrast MRI technique for continuous measurement of relative cerebral blood volume (rCBV) during global transient ischemia and subsequent hyperemia in a feline ischemia model is demonstrated. The measurements were obtained during a 10-min period of occlusion and 1-h period of reperfusion. Maximal hyperemic responses in gray matter, basal ganglia, and white matter (observed at 7,7, and 5 min, respectively) were 1.9 +/- 0.5, 1.8 +/- 0.3, and 1.7 +/- 0.6 times greater than baseline CBV (mean +/- SEM). Thirty to forty minutes after onset of reperfusion, CBV returned to normal. Thereafter, it decreased below baseline, nearing the control level by 1 h after onset of reperfusion. Steady state susceptibility-contrast MRI permits continuous, in vivo mapping of alterations in CBV.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Hamberg LM,Boccalini P,Stranjalis G,Hunter GJ,Huang Z,Halpern E,Weisskoff RM,Moskowitz MA,Rosen BRdoi
10.1002/mrm.1910350207subject
Has Abstractpub_date
1996-02-01 00:00:00pages
168-73issue
2eissn
0740-3194issn
1522-2594journal_volume
35pub_type
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