Abstract:
:Saline solutions of manganese ions (Mn2+) were used as articular contrast agents in magnetic resonance microscopy (9.4 T) of cartilage of chicken femoral condyles and pig temporomandibular joints. The diffusion of Mn2+ from the articular surface into the cartilage matrix led to a strong contrast enhancement in the cartilage. The combination of the high spatial resolution and the contrast enhancement allowed the visualization of fine structures (tissue types) in the cartilage, which correlate with the tissue zones in histological sections stained with cationic dyes. We assume that the electrostatic interactions between the negatively charged groups of the proteoglycans and Mn2+ are most important for the mechanism of contrast enhancement. Hence, the different signal intensities of the various zones of cartilage indicate differences in density of proteoglycans. The intraarticular injection of the cationic contrast agent could improve the possibility of an early diagnosis of cartilage dysfunction and degeneration.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Kusaka Y,Gründer W,Rumpel H,Dannhauer KH,Gersonde Kdoi
10.1002/mrm.1910240114subject
Has Abstractpub_date
1992-03-01 00:00:00pages
137-48issue
1eissn
0740-3194issn
1522-2594journal_volume
24pub_type
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