Abstract:
:In vivo, cardiac-gated, black-blood, and ex vivo magnetic resonance microscopy (MRM) images of the aortic root, and histopathology data were obtained from 12 transgenic and wild-type (WT) mice. MRM was performed using a black-blood imaging spin-echo sequence with upstream and downstream in-flow saturation pulses to obtain aortic root images in three contrast techniques: proton density-weighted (PDW), T(1)- (T(1)W), and T(2)-weighted (T(2)W). Aortic wall thickness and area were measured and correlated with histopathology data (R > 0.90). Ex vivo lesion components (lipid core, fibrous tissue, and cell tissue) were identified and characterized by differing image contrast in PDW, T(1)W, and T(2)W MRM, and by histopathology. The differences between WT and transgenic mice for maximal wall thickness and area were statistically significant (P < 0.05). This study demonstrates the feasibility of in vivo murine aortic root lesion assessment and ex vivo plaque characterization by MRM.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Itskovich VV,Choudhury RP,Aguinaldo JG,Fallon JT,Omerhodzic S,Fisher EA,Fayad ZAdoi
10.1002/mrm.10360subject
Has Abstractpub_date
2003-02-01 00:00:00pages
381-5issue
2eissn
0740-3194issn
1522-2594journal_volume
49pub_type
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:1997-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2019-02-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2015-08-01 00:00:00
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:2004-08-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2006-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1126
更新日期:2001-06-01 00:00:00
abstract::The pulse wave velocity (PWV) of aortic blood flow is considered a surrogate for aortic compliance. A new method using phase-contrast (PC)-MRI is presented whereby the spatial and temporal profiles of axial velocity along the descending aorta can be analyzed. Seventeen young healthy volunteers (the YH group), six olde...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21034
更新日期:2006-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910400115
更新日期:1998-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.26647
更新日期:2018-01-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350620
更新日期:1996-06-01 00:00:00
abstract:PURPOSE:MR-based quantification of liver magnetic susceptibility may enable field strength-independent measurement of liver iron concentration (LIC). However, susceptibility quantification is challenging, due to nonlocal effects of susceptibility on the B0 field. The purpose of this work is to demonstrate feasibility o...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24848
更新日期:2013-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910390204
更新日期:1998-02-01 00:00:00
abstract:PURPOSE:To exploit the improved comparability and hardware independency of quantitative MRI, databases of MR physical parameters in healthy tissue are required, to which tissue properties of patients can be compared. In this work, normative values for longitudinal and transverse relaxation times in the brain were estab...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27927
更新日期:2020-01-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910140225
更新日期:1990-05-01 00:00:00
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doi:10.1002/mrm.27343
更新日期:2019-01-01 00:00:00
abstract::Elastase-induced changes in lung morphology and function were detected in spontaneously breathing rats using conventional proton MRI at 4.7 T. A single dose of porcine pancreatic elastase (75 U/100 g body weight) or vehicle (saline) was administered intratracheally (i.t.) to male Brown Norway (BN) rats. MRI fluid sign...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
abstract::Prepolarized MRI uses pulsed magnetic fields to produce MR images by polarizing the sample at one field strength (approximately 0.5 T) before imaging at a much lower field (approximately 50 mT). Contrast reflecting the T(1) of the sample at an intermediate field strength is achieved by polarizing the sample and then a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20910
更新日期:2006-06-01 00:00:00
abstract::Standard MRI cine exams for the study of cardiac function are segmented over several heartbeats and thus require a breath-hold to minimize breathing motion artifacts, which is a current limitation of this approach. The purpose of this study was to develop a method for the measurement and correction of respiratory moti...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21711
更新日期:2008-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
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更新日期:2006-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22428
更新日期:2010-08-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199903)41:3<479::aid-mrm9>
更新日期:1999-03-01 00:00:00