Evidence for a contribution of paramagnetic ions to water proton spin-lattice relaxation in normal and malignant mouse tissues.

Abstract:

:Paramagnetic ions complexed to proteins may lose, retain, or enhance solvent paramagnetic relaxation (SPR) relative to free solution. We measured T1 and T2 of three mouse cancers, their normal counterparts, and six additional tissues. Long T1 of cancers was not caused by necrosis or by different contents of water, fat, or blood. Dissociable (TCA-extractable) and nondissociable (ashed) Mn, Cu, and Fe were measured by AA. Cancers had less Mn, Cu, and Fe than did normal counterparts. All 12 tissues had inverse correlations between T1 and dissociable Mn and Cu. For Mn alone to account for reduced T1, the extent to which SPR of the Mn-protein complexes would be enhanced is by factors of 0.6 to 13, below the maximum observed in Mn-enzymes. Different amounts of paramagnetic ion-protein complexes may account for part of the differences in T1 of water protons in different tissues, and the longer T1 of cancer cell water may be caused in part by reduced amounts of such complexes.

journal_name

Magn Reson Med

authors

Negendank W,Corbett T,Crowley M,Kellogg C

doi

10.1002/mrm.1910180204

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

280-93

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

18

pub_type

杂志文章
  • Inversion recovery radial MRI with interleaved projection sets.

    abstract::The radial trajectory has found applications in cardiac imaging because of its resilience to undersampling and motion artifacts. Recent work has shown that interleaved and weighted radial imaging can produce images with multiple contrasts from a single data set. This feature was investigated for inversion recovery ima...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20865

    authors: Peters DC,Botnar RM,Kissinger KV,Yeon SB,Appelbaum EA,Manning WJ

    更新日期:2006-05-01 00:00:00

  • An analytical solution for the SSFP signal in MRI.

    abstract::Among previous analyses of the steady-state free-precession (SSFP) signal in rapid MRI, one treatment resulted in equations that require the evaluation of infinite binomial series. Here, an analytical solution is derived by a transformation into the power series expansion of the derivative of the inverse sine function...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10410

    authors: Hänicke W,Vogel HU

    更新日期:2003-04-01 00:00:00

  • Effects of the acoustic noise of the gradient systems on fMRI: a study on auditory, motor, and visual cortices.

    abstract::MR acoustic, or sound, noise due to gradient pulsing has been one of the problems in MRI, both in patient scanning as well as in many areas of psychiatric and neuroscience research, such as brain fMRI. Especially in brain fMRI, sound noise is one of the serious noise sources that obscures the small signals obtainable ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910390224

    authors: Cho ZH,Chung SC,Lim DW,Wong EK

    更新日期:1998-02-01 00:00:00

  • Self-degrading, MRI-detectable hydrogel sensors with picomolar target sensitivity.

    abstract::Nanostructured hydrogels have been developed as synthetic tissues and scaffolds for cell and drug delivery, and as guides for tissue regeneration. A fundamental problem in the development of synthetic hydrogels is that implanted gel structure is difficult to monitor noninvasively. This work demonstrates that the aggre...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22570

    authors: Colomb J,Louie K,Massia SP,Bennett KM

    更新日期:2010-12-01 00:00:00

  • Perfusion mapping with multiecho multishot parallel imaging EPI.

    abstract::Echo-planar imaging (EPI) is the standard technique for dynamic susceptibility-contrast (DSC) perfusion MRI. However, EPI suffers from well-known geometric distortions, which can be reduced by increasing the k-space phase velocity. Moreover, the long echo times (TEs) used in DSC lead to signal saturation of the arteri...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21255

    authors: Newbould RD,Skare ST,Jochimsen TH,Alley MT,Moseley ME,Albers GW,Bammer R

    更新日期:2007-07-01 00:00:00

  • Characterization of white matter alterations in phenylketonuria by magnetic resonance relaxometry and diffusion tensor imaging.

    abstract::A multimodal MR study including relaxometry, diffusion tensor imaging (DTI), and MR spectroscopy was performed on patients with classical phenylketonuria (PKU) and matched controls, to improve our understanding of white matter (WM) lesions. Relaxometry yields information on myelin loss or malformation and may substant...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21422

    authors: Vermathen P,Robert-Tissot L,Pietz J,Lutz T,Boesch C,Kreis R

    更新日期:2007-12-01 00:00:00

  • Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis.

    abstract::Magnetization transfer imaging (MT) and localized proton spectroscopy (1H-MRS) were utilized in the evaluation of lesions (high signal abnormalities on T2-weighted images) and normal-appearing white matter (NAWM) in multiple sclerosis (MS). Eleven patients with a clinical diagnosis of MS were independently evaluated w...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320303

    authors: Hiehle JF Jr,Lenkinski RE,Grossman RI,Dousset V,Ramer KN,Schnall MD,Cohen JA,Gonzalez-Scarano F

    更新日期:1994-09-01 00:00:00

  • Joint image reconstruction and sensitivity estimation in SENSE (JSENSE).

    abstract::Parallel magnetic resonance imaging (pMRI) using multichannel receiver coils has emerged as an effective tool to reduce imaging time in various applications. However, the issue of accurate estimation of coil sensitivities has not been fully addressed, which limits the level of speed enhancement achievable with the tec...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21245

    authors: Ying L,Sheng J

    更新日期:2007-06-01 00:00:00

  • Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy.

    abstract::Cerebral metabolite concentrations and water content were measured by means of localized proton magnetic resonance spectroscopy in 50 children, while metabolite peak ratios in short echo time spectra were evaluated in 173 examinations. Normative curves for normal development were established for two cerebral locations...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910300405

    authors: Kreis R,Ernst T,Ross BD

    更新日期:1993-10-01 00:00:00

  • Specific absorption rate benefits of including measured electric field interactions in parallel excitation pulse design.

    abstract::Specific absorption rate management and excitation fidelity are key aspects of radiofrequency pulse design for parallel transmission at ultra-high magnetic field strength. The design of radiofrequency pulses for multiple channels is often based on the solution of regularized least-squares optimization problems for whi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23004

    authors: Deniz CM,Alon L,Brown R,Sodickson DK,Zhu Y

    更新日期:2012-01-01 00:00:00

  • Transverse relaxivity of iron oxide nanocrystals clustered in nanoemulsions: Experiment and theory.

    abstract:PURPOSE:To compare experimental transverse relaxivities of iron oxide nanocrystals (IONC) as a function of clustering and magnetic field strength with different theoretical model predictions. THEORY AND METHODS:Well-defined IONC clusters in nanoemulsions (NEs) of which both size and IONC loading could be judiciously t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25465

    authors: Hak S,Goa PE,Stenmark S,Bjerkholt FF,Haraldseth O

    更新日期:2015-09-01 00:00:00

  • Infimal convolution of total generalized variation functionals for dynamic MRI.

    abstract:PURPOSE:To accelerate dynamic MR applications using infimal convolution of total generalized variation functionals (ICTGV) as spatio-temporal regularization for image reconstruction. THEORY AND METHODS:ICTGV comprises a new image prior tailored to dynamic data that achieves regularization via optimal local balancing b...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26352

    authors: Schloegl M,Holler M,Schwarzl A,Bredies K,Stollberger R

    更新日期:2017-07-01 00:00:00

  • A highly sensitive lactate editing technique for surface coil spectroscopic imaging in vivo.

    abstract::A lactate editing sequence based on the use of spin-locking pulses with surface coils is described. The sequence retains more than 90% of the available lactate magnetization and suppresses at least 95% of the lipid signal in a single scan and ca. 99.5% after a simple two step cycle. The technique allows simultaneous o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290320

    authors: Bourgeois D,Kozlowski P

    更新日期:1993-03-01 00:00:00

  • Lactate imaging with Hadamard-encoded slice-selective multiple quantum coherence chemical-shift imaging.

    abstract::The ability to generate in vivo maps of lactate may have significant diagnostic utility in staging and treatment planning of a wide variety of cancers. The double selective multiple quantum filter technique (SelMQC) has been shown to be effective for nonlocalized detection of lactate with little or no interference fro...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21659

    authors: Pickup S,Lee SC,Mancuso A,Glickson JD

    更新日期:2008-08-01 00:00:00

  • Phosphonate-modified GdDTPA complexes. I. NMRD study of the solution behavior of new tissue-specific contrast agents.

    abstract::NMRD profiles, the magnetic field dependence of the water proton longitudinal relaxation rates, have been acquired for two new diphosphonate-modified GdDTPA complexes currently under evaluation as relaxation agents for the MRI detection of soft-tissue calcifications. Fresh dilute solutions show profiles identical to t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910170118

    authors: Adzamli IK,Blau M

    更新日期:1991-01-01 00:00:00

  • A one-step biomarker quantification methodology for DCE-MRI of adnexal masses: Capturing kinetic pattern from early to late enhancement.

    abstract:PURPOSE:To develop a one-step quantification approach that accounts for joint preprocessing and quantification of whole-range kinetics (early and late-phase washout) of dynamic contrast-enhanced (DCE) MRI of indeterminate adnexal masses. METHODS:Preoperative DCE-MRI of 43 (24 benign, 19 malignant) sonographically inde...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26743

    authors: Fathi Kazerooni A,Nabil M,Haghighat Khah H,Parviz S,Gity M,Saligheh Rad H

    更新日期:2018-02-01 00:00:00

  • Aortic 4D flow: quantification of signal-to-noise ratio as a function of field strength and contrast enhancement for 1.5T, 3T, and 7T.

    abstract:PURPOSE:To investigate for the first time the feasibility of aortic four-dimensional (4D) flow at 7T, both contrast enhanced (CE) and non-CE. To quantify the signal-to-noise ratio (SNR) in aortic 4D flow as a function of field strength and CE with gadobenate dimeglumine (MultiHance). METHODS:Six healthy male volunteer...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25317

    authors: Hess AT,Bissell MM,Ntusi NA,Lewis AJ,Tunnicliffe EM,Greiser A,Stalder AF,Francis JM,Myerson SG,Neubauer S,Robson MD

    更新日期:2015-05-01 00:00:00

  • Sweep MRI with algebraic reconstruction.

    abstract::In the recently proposed technique Sweep Imaging with Fourier Transform (SWIFT), frequency-modulated radiofrequency pulses are used in concert with simultaneous acquisition to facilitate MRI of samples with very short transverse relaxation time. In the present work, sweep MRI is reviewed from a reconstruction perspect...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22516

    authors: Weiger M,Hennel F,Pruessmann KP

    更新日期:2010-12-01 00:00:00

  • In vivo imaging of insulin-secreting human pancreatic ductal cells using MRI reporter gene technique: A feasibility study.

    abstract:PURPOSE:The purpose of this study was to investigate the feasibility of in vivo imaging of human pancreatic ductal cells by OATP1B3 reporter gene under MRI. METHODS:A human cell line (PANC-1) derived from the pancreatic ductal epithelium was used in this study. After transduction of OATP1B3, the cellular physiological...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27749

    authors: Wu MR,Hsiao JK,Liu HM,Huang YY,Tseng YJ,Chou PT,Weng TI,Yang CY

    更新日期:2019-08-01 00:00:00

  • Fast mapping of myocardial blood flow with MR first-pass perfusion imaging.

    abstract::Accurate and fast quantification of myocardial blood flow (MBF) with MR first-pass perfusion imaging techniques on a pixel-by-pixel basis remains difficult due to relatively long calculation times and noise-sensitive algorithms. In this study, Zierler's central volume principle was used to develop an algorithm for the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21559

    authors: Goldstein TA,Jerosch-Herold M,Misselwitz B,Zhang H,Gropler RJ,Zheng J

    更新日期:2008-06-01 00:00:00

  • Impact of transcytolemmal water exchange on estimates of tissue microstructural properties derived from diffusion MRI.

    abstract:PURPOSE:To investigate the influence of transcytolemmal water exchange on estimates of tissue microstructural parameters derived from diffusion MRI using conventional PGSE and IMPULSED methods. METHODS:Computer simulations were performed to incorporate a broad range of intracellular water life times τin (50-∞ ms), cel...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26309

    authors: Li H,Jiang X,Xie J,Gore JC,Xu J

    更新日期:2017-06-01 00:00:00

  • Modulation of the pharmacokinetics of macromolecular contrast material by avidin chase: MRI, optical, and inductively coupled plasma mass spectrometry tracking of triply labeled albumin.

    abstract::The goal of this work was to develop an MRI method for mapping the clearance of interstitial macromolecular plasma proteins after their extravasation from permeable blood vessels. To that end, a well-defined window of exposure to elevated blood levels was generated by inducing rapid clearance of macromolecular contras...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10638

    authors: Dafni H,Gilead A,Nevo N,Eilam R,Harmelin A,Neeman M

    更新日期:2003-11-01 00:00:00

  • Intersubject specific absorption rate variability analysis through construction of 23 realistic body models for prostate imaging at 7T.

    abstract:PURPOSE:For ultrahigh field (UHF) MRI, the expected local specific absorption rate (SAR) distribution is usually calculated by numerical simulations using a limited number of generic body models and adding a safety margin to take into account intersubject variability. Assessment of this variability with a large model d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27518

    authors: Meliadò EF,van den Berg CAT,Luijten PR,Raaijmakers AJE

    更新日期:2019-03-01 00:00:00

  • Commutator filter: a novel technique for the identification of structures producing significant susceptibility inhomogeneities and its application to functional MRI.

    abstract::A robust postprocessing method to detect regions of magnetic field change is presented. High resolution gradient echo data is acquired to create a complex baseline image. From this image, two low resolution images are obtained by applying a low pass filter on the magnitude image and the complex image, respectively. Su...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360518

    authors: Lai S,Reichenbach JR,Haacke EM

    更新日期:1996-11-01 00:00:00

  • Correction of phase errors in quantitative water-fat imaging using a monopolar time-interleaved multi-echo gradient echo sequence.

    abstract:PURPOSE:To propose a phase error correction scheme for monopolar time-interleaved multi-echo gradient echo water-fat imaging that allows accurate and robust complex-based quantification of the proton density fat fraction (PDFF). METHODS:A three-step phase correction scheme is proposed to address a) a phase term induce...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26485

    authors: Ruschke S,Eggers H,Kooijman H,Diefenbach MN,Baum T,Haase A,Rummeny EJ,Hu HH,Karampinos DC

    更新日期:2017-09-01 00:00:00

  • Simulation-based investigation of partially parallel imaging with a linear array at high accelerations.

    abstract::Partially parallel imaging strategies such as SMASH, SENSE, and PILS rely on the sensitivity distribution of phased array RF coils to reduce MRI imaging time. Using an N-element phased array, these techniques allow maximum accelerations, L, such that L < or = N, with acceleration defined as the factor by which scan ti...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10113

    authors: Bankson JA,Wright SM

    更新日期:2002-04-01 00:00:00

  • Robust 4D flow denoising using divergence-free wavelet transform.

    abstract:PURPOSE:To investigate four-dimensional flow denoising using the divergence-free wavelet (DFW) transform and compare its performance with existing techniques. THEORY AND METHODS:DFW is a vector-wavelet that provides a sparse representation of flow in a generally divergence-free field and can be used to enforce "soft" ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25176

    authors: Ong F,Uecker M,Tariq U,Hsiao A,Alley MT,Vasanawala SS,Lustig M

    更新日期:2015-02-01 00:00:00

  • T2 measurement in articular cartilage: impact of the fitting method on accuracy and precision at low SNR.

    abstract::T2 relaxation time is a promising MRI parameter for the detection of cartilage degeneration in osteoarthritis. However, the accuracy and precision of the measured T2 may be substantially impaired by the low signal-to-noise ratio of images available from clinical examinations. The purpose of this work was to assess the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22178

    authors: Raya JG,Dietrich O,Horng A,Weber J,Reiser MF,Glaser C

    更新日期:2010-01-01 00:00:00

  • Mechanics and imaging of the macrocirculation.

    abstract::The mechanics of the macrocirculation are examined as a basis for imaging blood flow within the system. The macrocirculation is defined as that part of the circulation in which inertial forces are not negligible compared to viscous forces and as such in human subjects comprises the heart and large blood vessels. Becau...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910140204

    authors: Caro CG,Parker KH

    更新日期:1990-05-01 00:00:00

  • Ventricular shape biomarkers for Alzheimer's disease in clinical MR images.

    abstract::The aim of this work was to identify ventricular shape-based biomarkers in MR images to discriminate between patients with Alzheimer's disease (AD) and healthy elderly. Clinical MR images were collected for 58 patients and 28 age-matched healthy controls. After normalizing all the images the ventricular cerebrospinal ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21471

    authors: Ferrarini L,Palm WM,Olofsen H,van der Landen R,van Buchem MA,Reiber JH,Admiraal-Behloul F

    更新日期:2008-02-01 00:00:00