Abstract:
:The ability to generate in vivo maps of lactate may have significant diagnostic utility in staging and treatment planning of a wide variety of cancers. The double selective multiple quantum filter technique (SelMQC) has been shown to be effective for nonlocalized detection of lactate with little or no interference from other signals. Here the SelMQC technique has been combined with longitudinal Hadamard slice selection and chemical shift imaging (CSI) to yield slice-selective images of lactate. The technique is shown to be effective in phantoms and in WSU-DLCL2 xenografts implanted in flanks of SCID mice. Tumors exhibited an annulus of elevated lactate concentration surrounding a necrotic tumor core.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Pickup S,Lee SC,Mancuso A,Glickson JDdoi
10.1002/mrm.21659subject
Has Abstractpub_date
2008-08-01 00:00:00pages
299-305issue
2eissn
0740-3194issn
1522-2594journal_volume
60pub_type
杂志文章abstract:PURPOSE:Banding artifacts in images acquired by balanced steady-state free precession (bSSFP) remain a challenge in MRI as they considerably reduce image quality, and diagnostic value deteriorates accordingly. As the steady-state tolerates small shifts in frequency, it is possible to acquire frequency-modulated bSSFP. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26630
更新日期:2017-12-01 00:00:00
abstract::The intra-individual and inter-individual variations of the global N-acetylaspartate (NAA) concentration were measured in a cohort of five 42+/-5 year-old normal females. The total NAA signal from the whole head was obtained with non-localized non-echo proton spectroscopy (1H-MRS) and converted into absolute mole amou...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/mrm.1910400506
更新日期:1998-11-01 00:00:00
abstract::With diffusion tensor imaging, the diffusion of water molecules through brain structures is quantified by parameters, which are estimated assuming monoexponential diffusion-weighted signal attenuation. The estimated diffusion parameters, however, depend on the diffusion weighting strength, the b-value, which hampers t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22603
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Real-time assessment of ventricular volumes requires high acceleration factors. Residual convolutional neural networks (CNN) have shown potential for removing artifacts caused by data undersampling. In this study, we investigated the ability of CNNs to reconstruct highly accelerated radial real-time data in pat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27480
更新日期:2019-02-01 00:00:00
abstract::Consideration of spatially variable noise fields is becoming increasingly necessary in MRI given recent innovations in artifact identification and statistically driven image processing. Fast imaging methods enable study of difficult anatomical targets and improve image quality but also increase the spatial variability...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22013
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:Endothelial nitric oxide synthase (eNOS) plays a central role in regulating vascular tone, blood flow, and microvascular permeability. Endothelial dysfunction, including eNOS dysfunction, is an early biomarker of vascular disease. This study aimed to show that myocardial T1 mapping during nitric oxide synthase ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26870
更新日期:2018-04-01 00:00:00
abstract::Several methods have been proposed for overcoming the effects of radiofrequency (RF) magnetic field inhomogeneity in high-field MRI. Some of these methods rely at least in part on the ability to independently control magnitude and phase of different drives in either one multielement RF coil or in different RF coils in...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21013
更新日期:2006-10-01 00:00:00
abstract::The equal-phase line (EPL) algorithm is proposed as a means of allowing rapid Fourier transform (FT) reconstruction of MR image data acquired on a non-Cartesian grid. The pixels on the image are grouped according to their positions. The pixels in a group have the same phase in the complex exponential function -exp[j2p...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10165
更新日期:2002-06-01 00:00:00
abstract::A common type of motion present in clinical magnetic resonance imaging examinations is rotational motion, such as that due to voluntary motion during head examinations. The correction scheme presented in this work offers a method for eliminating the effects of rotations within the imaging plane. Integral to the implem...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910330511
更新日期:1995-05-01 00:00:00
abstract::Aggregation of human erythrocytes at physiological hematocrit by hydroxyethyl starch (HES) was investigated with a 1H nuclear magnetic resonance method which measures the erythrocyte mean water exchange time, tau a. A relationship that takes into account the effect of the aggregate as the water-exchanging unit was use...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910050108
更新日期:1987-07-01 00:00:00
abstract:PURPOSE:Human connectomics necessitates high-throughput, whole-brain reconstruction of multiple white matter fiber bundles. Scaling up tractography to meet these high-throughput demands yields new fiber tracking challenges, such as minimizing spurious connections and controlling for gyral biases. The aim of this study ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27471
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:To test the feasibility of using the SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) technique, which uses the partial separability of spectroscopic data, for high resolution hyperpolarized (HP) 13 C spectroscopic imaging. METHODS:Numerical simulations were performed to investigate the i...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27061
更新日期:2018-08-01 00:00:00
abstract::Fe(III)meso-tetra(4-sulfonatophenyl)porphine (Fe-TPPS4) has been investigated as a potential pH-sensitive nuclear magnetic resonance (NMR) proton image contrast agent. Relaxation rates (1/T1 and 1/T2) of water protons were measured as a function of pH and concentration of Fe-TPPS4 in phosphate-buffered isotonic saline...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910050313
更新日期:1987-09-01 00:00:00
abstract::The detection of free radical reactions in a gelatin sample irradiated by a heavy-ion beam was tested using electron paramagnetic resonance (EPR) spectroscopic and MRI methods. Geometry and the amount of free radical generation in a sample are described. A reaction mixture containing glutathione and a nitroxyl radical...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21958
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:To improve imaging performance for body MRI with a local transmit array at 10.5T, the geometry of a dipole antenna was optimized to achieve lower peak specific absorption rate (SAR) levels and a more uniform transmit profile. METHODS:Electromagnetic simulations on a phantom were used to evaluate the SAR and ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28297
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to develop a technique for rapid collection of chemical exchange saturation transfer images with the saturation varied to modulate signal loss transfer and enhance contrast. METHODS:Multi-echo Length and Offset VARied Saturation (MeLOVARS) divides the saturation pulse of length Tsat i...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25567
更新日期:2015-02-01 00:00:00
abstract::When deoxygenated, blood behaves as an effective susceptibility contrast agent. Changes in brain oxygenation can be monitored using gradient-echo echo-planar imaging. With this technique, difference images also demonstrate that blood oxygenation is increased during periods of recovery from respiratory challenge. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910220117
更新日期:1991-11-01 00:00:00
abstract::The investigation of flow behavior in coronary arteries is of great importance for an understanding of heart failure and heart regulation mechanisms. The purpose of the present study was to demonstrate that flow velocity can be quantified in the coronary arteries of the isolated rat heart with high-resolution phase co...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10563
更新日期:2003-09-01 00:00:00
abstract::A new approach to autocalibrating, coil-by-coil parallel imaging reconstruction, is presented. It is a generalized reconstruction framework based on self-consistency. The reconstruction problem is formulated as an optimization that yields the most consistent solution with the calibration and acquisition data. The appr...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22428
更新日期:2010-08-01 00:00:00
abstract::The design of a piezoelectric-controlled trimmer capacitor and its use as a tuning element of an MRI surface coil at 63.8 MHz are described. It is found that image quality does not depend strongly on match of the coil to the transmission line but that tuning can be a significant factor. The work is intended to lead ev...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910120106
更新日期:1989-10-01 00:00:00
abstract::Multislice MR images obtained using a fast spin-echo (FSE) readout are strongly affected by magnetization transfer (MT) effects, which will cause a decrease in the observed longitudinal relaxation times for tissues with a large bound water component. This is pertinent for FSE-based inversion-recovery (IR) sequences, a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21338
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:Phosphorus spectroscopy (31 P-MRS) is a proven method to probe cardiac energetics. Studies typically report the phosphocreatine (PCr) to adenosine triphosphate (ATP) ratio. We focus on another 31 P signal: inorganic phosphate (Pi), whose chemical shift allows computation of myocardial pH, with Pi/PCr providing ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28494
更新日期:2021-03-01 00:00:00
abstract::A 3D sequence for dynamic susceptibility imaging is proposed which combines echo-shifting principles (such as PRESTO), sensitivity encoding (SENSE), and partial-Fourier acquisition. The method uses a moderate SENSE factor of 2 and takes advantage of an alternating partial k-space acquisition in the "slow" phase encode...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10599
更新日期:2003-10-01 00:00:00
abstract::Hyperpolarized gases ((129)Xe and (3)He) are being used increasingly in both MRI and NMR spectroscopy studies. However, it has been shown that carrier agents are required to preserve the long relaxation times of gases in biological fluids. Optimized gas transport can be achieved through controlled T(1) and T(2) measur...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10476
更新日期:2003-06-01 00:00:00
abstract:PURPOSE:To assess the risk of radiofrequency (RF)-induced heating in patients with MR-conditional pacemaker (PM) systems, in the presence of another lead abandoned from a previous implant. METHODS:Four commercial pacemaker leads were placed beside a MR-conditional PM system, inside a human trunk simulator. The phantom...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25106
更新日期:2015-01-01 00:00:00
abstract::For clinical 31P MR spectroscopic imaging (MRSI) studies, where signal averaging is necessary, some improvement of sensitivity and spatial response function may be achieved by acquiring data over a spherical k-space volume and varying the number of averages acquired in proportion to the desired spatial filter. Eight d...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910360321
更新日期:1996-09-01 00:00:00
abstract::Multiple receivers can be utilized to enhance the spatiotemporal resolution of MRI by employing the parallel imaging technique. Previously, we have reported the L-curve Tikhonov regularization technique to mitigate noise amplification resulting from the geometrical correlations between channels in a coil array. Nevert...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21356
更新日期:2007-10-01 00:00:00
abstract::The apparent diffusion coefficient (ADC) in the optic nerve was measured from diffusion-weighted magnetic resonance imaging using an intravoxel incoherent motion (IVIM) sequence. The subjects were seven normal volunteers and eight patients with multiple sclerosis (MS) with a total of four optic nerves with acute neuri...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910380317
更新日期:1997-09-01 00:00:00
abstract::A single-shot, two-echo method for the simultaneous detection of multiple-quantum (MQ)-filtered gamma-aminobutyric acid (GABA) and creatine (Cr) was developed and demonstrated in the human brain in vivo at 3 Tesla. The simultaneously measured Cr singlet served as a navigator for the spectral phase of GABA and any freq...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20082
更新日期:2004-06-01 00:00:00
abstract::In in vivo phosphorus magnetic resonance spectroscopy (MRS), spectroscopic imaging (SI) can be used as a flexible localization technique, producing spectra from multiple volumes in a single examination. Presented here are phosphorus SI studies of human organs in which a selective-volume SI reconstruction was used rath...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910120302
更新日期:1989-12-01 00:00:00