Phosphorus-31 magnetic resonance spectroscopy in humans by spectroscopic imaging: localized spectroscopy and metabolite imaging.

Abstract:

:In in vivo phosphorus magnetic resonance spectroscopy (MRS), spectroscopic imaging (SI) can be used as a flexible localization technique, producing spectra from multiple volumes in a single examination. Presented here are phosphorus SI studies of human organs in which a selective-volume SI reconstruction was used rather than the usual array-format SI reconstruction. A linear predictor technique was used to estimate the initial points of the free induction decay missing because of the delay needed for phase-encoding gradients, significantly reducing the baseline artifacts which commonly complicate interpretation of SI spectra. In studies of heart, brain, liver, and kidney, the performance of SI was found to compare favorably with that of ISIS. SI phosphorus metabolite intensity images from a brain tumor patient were obtained at 2 X 2-cm in-plane resolution (with "slice" thickness of roughly 16 cm, determined by coil sensitivity) in 34 min, demonstrating the feasibility of obtaining clinically useful metabolite images in clinically reasonable examination times.

journal_name

Magn Reson Med

authors

Twieg DB,Meyerhoff DJ,Hubesch B,Roth K,Sappey-Marinier D,Boska MD,Gober JR,Schaefer S,Weiner MW

doi

10.1002/mrm.1910120302

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

291-305

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

12

pub_type

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