Abstract:
:The success in utilizing in vivo NMR to identify and/or monitor metabolic abnormalities will be determined in large part on the reliability with which the spectral parameters of the metabolites present can be measured. For these reasons it is clear that there is a need for the development of algorithms with which to obtain quantitatively reliable estimates of the spectral parameters of the peaks present. In this report we describe an adaptation of the simplex algorithm which we have found useful in fitting in vivo spectral data in the frequency domain. This simplex algorithm was implemented on an IBM-PC AT compatible computer. We evaluated the simplex algorithm on three representative kinds of spectral data: a simulated spectrum, 31P spectrum of normal calf muscle, and the 31P spectrum of a pediatric patient with a brain tumor. In each case we generated a set of spectra by adding varying amounts of noise. On the basis of our simulations and the two examples discussed, we conclude that the simplex method generates parameters which are reliable estimates of the areas of the peaks present when the signal-to-noise is above 8:1 for phosphocreatine. We found that the speed of convergence of the algorithm was improved by overestimating the linewidths of the peaks present. We also found that the method converged more rapidly in the presence of a moderate amount of noise. We conclude that the algorithm described here can provide a robust method with which to analyze in vivo spectra in a quantitative manner. Because the method requires little user intervention, it lends itself to implementation in a semi-, or fully, automated fashion.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Lenkinski RE,Allman T,Scheiner JD,Deming SNdoi
10.1002/mrm.1910100306subject
Has Abstractpub_date
1989-06-01 00:00:00pages
338-48issue
3eissn
0740-3194issn
1522-2594journal_volume
10pub_type
杂志文章abstract::MRI evaluations of intramyocardial hemorrhage in acute infarction have relied on T(2) and T(2)(*) shortening only. We propose a more comprehensive evaluation of hemorrhagic infarction based on the concept that fluctuations in T(2) and T(1) relaxation in acute reperfused infarction will reflect transient edema and hemo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21079
更新日期:2006-12-01 00:00:00
abstract::An arterial spin labeling technique using separate RF labeling and imaging coils was used to obtain multislice perfusion images of the human brain at 3 T. Continuous RF irradiation at a peak power of 0.3 W was applied to the carotid arteries to adiabatically invert spins. Labeling was achieved without producing magnet...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199906)41:6<1093::aid-mrm4
更新日期:1999-06-01 00:00:00
abstract::This work aimed to investigate the effects of administering Gd-DTPA on the BOLD effect, and to determine the feasibility of using this approach to measure fractional changes in blood volume and blood oxygenation on neuronal activation during a visual paradigm. A linear relationship between cortical R(2)(*) and the int...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10340
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:The ultimate intrinsic signal-to-noise ratio (UISNR) is normally calculated using electrodynamic simulations with a complete basis of modes. Here, we provide an exact solution for the UISNR at the center of a dielectric sphere and assess how accurately this solution approximates UISNR away from the center. MET...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27207
更新日期:2018-11-01 00:00:00
abstract::Chemical shift imaging benefits from signal-to-noise ratio (SNR) and chemical shift dispersion increases at stronger main field such as 7 Tesla, but the associated shorter radiofrequency (RF) wavelengths encountered require B1+ mitigation over both the spatial field of view (FOV) and a specified spectral bandwidth. Th...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21834
更新日期:2009-02-01 00:00:00
abstract::Chemical shifts were extracted from in vivo 3-dimensional 31P NMR CSI data and pH images were constructed. The images could spatially resolve tissue pH ranging from 5.8 to 7.2 (with uncertainty of 0.11-0.17 pH unit) in an ischemia-reperfusion model of diabetic rat calf muscles. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910290214
更新日期:1993-02-01 00:00:00
abstract:PURPOSE:To develop and demonstrate the feasibility of a new technique for respiratory-gated, fat-suppressed, three-dimensional spoiled gradient-recalled echo (3D-SPGR) with navigator gating for more accurate and robust motion detection. METHODS:A navigator-gated 3D-SPGR technique was modified to include a wait period ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24902
更新日期:2014-07-01 00:00:00
abstract::The role of relative cerebral blood volume (rCBV) in the early response of blood oxygenation level-dependent (BOLD) signal following sensory stimulation was assessed. Magnetic resonance imaging (MRI) measurements of rCBV and BOLD signal as a function of time (t) were compared with relative cerebral blood flow (rCBF) o...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199902)41:2<247::aid-mrm6>
更新日期:1999-02-01 00:00:00
abstract::Respiratory motion and pulsatile blood flow can generate artifacts in morphological and functional lung imaging. Total acquisition time, and thus the achievable signal to noise ratio, is limited when performing breath-hold and/or electrocardiogram-triggered imaging. To overcome these limitations, imaging during free r...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21846
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:To develop a method that fits a multipool model to z-spectra acquired from non-steady state sequences, taking into account the effects of variations in T1 or B1 amplitude and the results estimating the parameters for a four-pool model to describe the z-spectrum from the healthy brain. METHODS:We compared measu...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26459
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:Over the last two decades, extended criteria have promoted an increased number of donor livers available for liver transplantation. But posttransplant graft loss is still a major concern. Macrovesicular hepatic steatosis (MHS) is recognized as the most significant prognostic histologic parameter in predicting p...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28592
更新日期:2020-11-16 00:00:00
abstract::Multiple-slice perfusion imaging by continuous arterial spin labeling (CASL) is made possible by amplitude modulation (AM) of the labeling RF pulse, but perfusion sensitivity is reduced relative to the single-slice technique. A computer model of the Bloch equations for velocity driven adiabatic fast passage was develo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20604
更新日期:2005-09-01 00:00:00
abstract:PURPOSE:Breath-holding is an established strategy for reducing motion artifacts in abdominal imaging. However, the breath-holding capabilities of patients are often overstrained by scans with large coverage and high resolution. In this work, a new strategy for coping with resulting incomplete breath-holds in abdominal ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24829
更新日期:2014-05-01 00:00:00
abstract::As the static magnetic field strength used in human magnetic resonance imaging increases, the wavelength of the corresponding radiofrequency field becomes comparable to the dimensions of the coil and volume of interest. The dielectric resonance effects that arise in this full wavelength regime may be partially compens...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20583
更新日期:2005-08-01 00:00:00
abstract::Phase-sensitive inversion-recovery (PSIR) imaging may provide enhanced T(1) contrast. However, clinical implementation of PSIR imaging is hindered because image reconstruction with this method often lacks robustness and requires manual intervention, particularly for data acquired in multiple slices and with phased-arr...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20414
更新日期:2005-04-01 00:00:00
abstract::In past decades, much effort has been invested in developing therapies for spinal injuries. Lack of standardization of clinical read-out measures, however, makes direct comparison of experimental therapies difficult. Damage and therapeutic effects in vivo are routinely evaluated using rather subjective behavioral test...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20888
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:A method for the quantification of perfusion in murine myocardium is demonstrated. The method allows for the reconstruction of perfusion maps on arbitrary time points in the heart cycle while addressing problems that arise due to the irregular heart beat of mice. METHODS:A flow-sensitive alternating inversion ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25526
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:We aimed to develop a novel free-breathing cardiac diffusion tensor MRI (DT-MRI) approach, M2-MT-MOCO, capable of whole left ventricular coverage that leverages second-order motion compensation (M2) diffusion encoding and multitasking (MT) framework to efficiently correct for respiratory motion (MOCO). METHODS...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28611
更新日期:2020-11-30 00:00:00
abstract::In an effort to develop MRI methods for the evaluation of tumor angiogenesis (new blood vessel formation), MRI-derived cerebral blood volume (CBV) information has been compared to histologic measures of microvessel density (MVD). Although MVD is a standard marker of angiogenesis, it is not a direct correlate of the vo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1252
更新日期:2001-10-01 00:00:00
abstract::An in vitro study was performed to investigate the effects of B(o) inhomogeneity on magnetic resonance images of flow. Controlled inhomogeneity gradients (Gi) were applied and the magnitude of the artifacts produced was quantified for different echo delay times (TE). Both steady and pulsatile flows were examined. In t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350116
更新日期:1996-01-01 00:00:00
abstract::The image intensity in magnetic resonance magnitude images in the presence of noise is shown to be governed by a Rician distribution. Low signal intensities (SNR < 2) are therefore biased due to the noise. It is shown how the underlying noise can be estimated from the images and a simple correction scheme is provided ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910340618
更新日期:1995-12-01 00:00:00
abstract::The use of phase correlation to detect rigid-body translational motion is reviewed and applied to individual echotrains in turbo-spin-echo data acquisition. It is shown that when the same echotrain is acquired twice, the subsampled correlation provides an array of delta-functions, from which the motion that occurred b...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21883
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:We incorporate simultaneous multislice (SMS) acquisition into MR fingerprinting (MRF) to accelerate the MRF acquisition. METHODS:The t-Blipped SMS-MRF method is achieved by adding a Gz blip before each data acquisition window and balancing it with a Gz blip of opposing polarity at the end of each TR. Thus the ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25799
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:As the premiere modality for brain imaging, MRI could find wider applicability if lightweight, portable systems were available for siting in unconventional locations such as intensive care units, physician offices, surgical suites, ambulances, emergency rooms, sports facilities, or rural healthcare sites. METH...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25147
更新日期:2015-02-01 00:00:00
abstract::The sensitivity of diffusion-weighted MRI was compared to that of T2-weighted MRI following temporary middle cerebral artery occlusion (MCA-O) for 33 min followed by 4 h of reperfusion in rats. Diffusion-weighted spin-echo images using strong gradients (b value of 1413 s/mm2) demonstrated a significant increase in sig...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910180106
更新日期:1991-03-01 00:00:00
abstract::Dynamic susceptibility contrast (DSC) MRI is now increasingly used for measuring perfusion in many different applications. The quantification of DSC data requires the measurement of the arterial input function (AIF) and the deconvolution of the tissue concentration time curve. One of the most accepted deconvolution me...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200009)44:3<466::aid-mrm18>3.0.c
更新日期:2000-09-01 00:00:00
abstract::A new approach to autocalibrating, coil-by-coil parallel imaging reconstruction, is presented. It is a generalized reconstruction framework based on self-consistency. The reconstruction problem is formulated as an optimization that yields the most consistent solution with the calibration and acquisition data. The appr...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22428
更新日期:2010-08-01 00:00:00
abstract::A demonstration of MR guided thermal surgery involved experiments with imaging of focused ultrasound in an MRI system, measurements of the thermal transients and a thermal analysis of the resulting images. Both the heat distribution and the creation of focused ultrasound lesions in gel phantoms, in vitro bovine muscle...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910300115
更新日期:1993-07-01 00:00:00
abstract::Parallel imaging presents a promising approach for MRI of hyperpolarized nuclei, as the penalty in signal-to-noise ratio typically encountered with (1)H MRI due to a reduction in acquisition time can be offset by an increase in flip angle. The signal-to-noise ratio of hyperpolarized MRI generally exhibits a strong dep...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22962
更新日期:2011-12-01 00:00:00
abstract::A fast, two-coil, pseudo-continuous labeling scheme is presented. This new scheme permits the collection of a multislice subtraction pair in <3 s, depending on the subject's arterial transit times. The method consists of acquiring both control and tag images immediately after a labeling period that matches the arteria...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10733
更新日期:2004-03-01 00:00:00