Gradient, high-resolution, magic-angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue.

Abstract:

:The recently developed technique of gradient, high-resolution magic-angle spinning NMR (g-hr-MAS-NMR) spectroscopy was applied to the study of ex vivo human lipoma and liposarcoma tissue. Compared with conventional 1H-NMR, the g-hr-MAS method yielded a large improvement in spectral resolution and permitted the detection of metabolite resonance's in a well-differentiated liposarcoma that was not observed in spectra of similar samples obtained using nonspinning NMR methods. These findings suggest that g-hr-MAS-NMR spectroscopy provides a key improvement in spectral quality for ex vivo lipoma and liposarcoma tissue thereby permitting a more precise determination of tissue metabolite composition than conventional nonspinning NMR methods.

journal_name

Magn Reson Med

authors

Millis KK,Maas WE,Cory DG,Singer S

doi

10.1002/mrm.1910380307

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

399-403

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

38

pub_type

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