Investigating the BOLD effect during infusion of Gd-DTPA using rapid T2* mapping.

Abstract:

:This work aimed to investigate the effects of administering Gd-DTPA on the BOLD effect, and to determine the feasibility of using this approach to measure fractional changes in blood volume and blood oxygenation on neuronal activation during a visual paradigm. A linear relationship between cortical R(2)(*) and the intravascular concentration of Gd-DTPA was demonstrated. The change in R(2)(*) in the visual cortex on activation at 3 T (in the absence of Gd-DTPA) was found to be 1.38 +/- 0.31 s(-1) (N = 4). The fractional change in total blood volume during visual activation was calculated to be 28% +/- 7% (N = 4). The absolute increase in venous blood oxygenation on activation (DeltaY) was estimated to be 21% +/- 4% (N = 4) (assuming HCT = 0.4, resting blood oxygenation = 60%, fraction of volume change that was venous = 36%, and the resting venous fraction of the blood volume = 70%). Simulations showed that the estimated change in venous blood oxygenation was sensitive to the assumed venous blood fraction, and that the estimated fractional change in blood oxygenation was insensitive to whether the change in blood volume occurred in the arterial or venous network.

journal_name

Magn Reson Med

authors

Pears JA,Francis ST,Butterworth SE,Bowtell RW,Gowland PA

doi

10.1002/mrm.10340

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

61-70

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

49

pub_type

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