In vivo MR imaging and spectroscopy using hyperpolarized 129Xe.

Abstract:

:Hyperpolarized 129Xe has been used to obtain gas phase images of mouse lung in vivo, showing distinct ventilation variation as a function of the breathing cycle. Spectra of 129Xe in the thorax show complex structure in both the gas phase (-4 to 3 ppm) and tissue-dissolved (190-205 ppm) regions. The alveolar gas peak shows correlated intensity and frequency oscillations, both attributable to changes in lung volume during breathing. The two major dissolved peaks near 195-200 ppm are attributed to lung parenchyma and to blood; they reach maximum intensity in 5-10 s and decay with an apparent T1 of 30 s. Another peak at 190 ppm takes 20-30 s to reach maximum; this must represent other well-vascularized tissue (e.g., heart and other muscles) in the thorax. The maximum integrated area of the tissue components reaches 30-80% of the maximum alveolar gas area, indicating that imaging at tissue frequencies can be achieved.

journal_name

Magn Reson Med

authors

Wagshul ME,Button TM,Li HF,Liang Z,Springer CS,Zhong K,Wishnia A

doi

10.1002/mrm.1910360203

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

183-91

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

36

pub_type

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