Myocardial fat quantification in humans: Evaluation by two-point water-fat imaging and localized proton spectroscopy.

Abstract:

:Proton MR spectroscopy ((1)H-MRS) has been used for in vivo quantification of intracellular triglycerides within the sarcolemma. The purpose of this study was to assess whether breath-hold dual-echo in- and out-of-phase MRI at 3.0 T can quantify the fat content of the myocardium. Biases, including T(1), T*(2), and noise, that confound the calculation of the fat fraction were carefully corrected. Thirty-four of 46 participants had both MRI and MRS data. The fat fractions from MRI showed a strong correlation with fat fractions from MRS (r = 0.78; P < 0.05). The mean myocardial fat fraction for all 34 subjects was 0.7 +/- 0.5% (range: 0.11-3%) assessed with MRS and 1.04 +/- 0.4% (range: 0.32-2.44%) assessed with in- and out-of-phase MRI (P < 0.05). Scanning times were less than 15 sec for Dixon imaging, plus an additional minute for the acquisition used for T*(2) calculation, and 15-20 min for MRS. The average postprocessing time for MRS was 3 min and 5 min for MRI including T*(2) measurement. We conclude that the dual echo method provides a rapid means to detect and quantifying myocardial fat content in vivo. Correction/adjustment for field inhomogeneity using three or more echoes seems crucial for the dual echo approach.

journal_name

Magn Reson Med

authors

Liu CY,Redheuil A,Ouwerkerk R,Lima JA,Bluemke DA

doi

10.1002/mrm.22289

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

892-901

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

63

pub_type

杂志文章
  • Rapid acquisition of helium-3 and proton three-dimensional image sets of the human lung in a single breath-hold using compressed sensing.

    abstract:PURPOSE:To develop and validate a method for acquiring helium-3 ((3) He) and proton ((1) H) three-dimensional (3D) image sets of the human lung with isotropic spatial resolution within a 10-s breath-hold by using compressed sensing (CS) acceleration, and to assess the fidelity of undersampled images compared with fully...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25499

    authors: Qing K,Altes TA,Tustison NJ,Feng X,Chen X,Mata JF,Miller GW,de Lange EE,Tobias WA,Cates GD Jr,Brookeman JR,Mugler JP 3rd

    更新日期:2015-10-01 00:00:00

  • Dynamic glucose-enhanced (DGE) MRI in the human brain at 7 T with reduced motion-induced artifacts based on quantitative R1ρ mapping.

    abstract:PURPOSE:Dynamic glucose-enhanced (DGE)-MRI based on chemical exchange-sensitive MRI, that is, glucoCEST and gluco-chemical exchange-sensitive spin-lock (glucoCESL), is intrinsically prone to motion-induced artifacts because the final DGE contrast relies on the difference of images, which were acquired with a time gap o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28112

    authors: Boyd PS,Breitling J,Zimmermann F,Korzowski A,Zaiss M,Schuenke P,Weinfurtner N,Schlemmer HP,Ladd ME,Bachert P,Paech D,Goerke S

    更新日期:2020-07-01 00:00:00

  • Generalized matched filtering for time-resolved MR angiography of pulsatile flow.

    abstract::Generating flow-specific images (arteriograms, venograms) with optimal signal-to-noise ratios for time-resolved MR angiography is a conditional maximum problem, and its solutions are generalized matched filters. We have investigated six matched filters, corresponding to all possible combinations of three flow suppress...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910300511

    authors: Wang Y,Weber DM,Korosec FR,Mistretta CA,Grist TM,Swan JS,Turski PA

    更新日期:1993-11-01 00:00:00

  • Metabolite 1H relaxation in normal and hyponatremic brain.

    abstract::Proton spin relaxation rate constants in normal and hyponatremic rat brain were measured to determine the sensitivity of metabolite relaxation properties to cytotoxic edema and to quantify metabolite concentration in normal and edematous brain. Relaxation rate constants for protons of water and spectral regions with d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910350510

    authors: Rooney WD,Ebisu T,Mancuso A,Graham S,Weiner MW,Maudsley AA

    更新日期:1996-05-01 00:00:00

  • Effect of feature extraction for brain tumor classification based on short echo time 1H MR spectra.

    abstract::This study examines the effect of feature extraction methods prior to automated pattern recognition based on magnetic resonance spectroscopy (MRS) for brain tumor diagnosis. Since individual inspection of spectra is time-consuming and requires specific spectroscopic expertise, the introduction of clinical decision sup...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21626

    authors: Luts J,Poullet JB,Garcia-Gomez JM,Heerschap A,Robles M,Suykens JA,Van Huffel S

    更新日期:2008-08-01 00:00:00

  • Lung imaging under free-breathing conditions.

    abstract::Respiratory motion and pulsatile blood flow can generate artifacts in morphological and functional lung imaging. Total acquisition time, and thus the achievable signal to noise ratio, is limited when performing breath-hold and/or electrocardiogram-triggered imaging. To overcome these limitations, imaging during free r...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21846

    authors: Oechsner M,Pracht ED,Staeb D,Arnold JF,Köstler H,Hahn D,Beer M,Jakob PM

    更新日期:2009-03-01 00:00:00

  • Integrated volume-selective/spectral editing 1H NMR and postdetection signal processing for the sensitive determination of lactate.

    abstract::A new volume selection/spectral editing pulse sequence (VOSING) is presented. The features specific to the technique are that the volume selection and the editing intervals coincide and that no decoupling is necessary. The pulse sequence can be applied under both homo- and heteronuclear conditions. Phantom experiments...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910080108

    authors: Knüttel A,Rommel E,Clausen M,Kimmich R

    更新日期:1988-09-01 00:00:00

  • Oxygen extraction fraction mapping at 3 Tesla using an artificial neural network: A feasibility study.

    abstract:PURPOSE:The oxygen extraction fraction (OEF) is an important biomarker for tissue-viability. MRI enables noninvasive estimation of the OEF based on the blood-oxygenation-level-dependent (BOLD) effect. Quantitative OEF-mapping is commonly applied using least-squares regression (LSR) to an analytical tissue model. Howeve...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26749

    authors: Domsch S,Mürle B,Weingärtner S,Zapp J,Wenz F,Schad LR

    更新日期:2018-02-01 00:00:00

  • Positive contrast visualization of iron oxide-labeled stem cells using inversion-recovery with ON-resonant water suppression (IRON).

    abstract::In proton magnetic resonance imaging (MRI) metallic substances lead to magnetic field distortions that often result in signal voids in the adjacent anatomic structures. Thus, metallic objects and superparamagnetic iron oxide (SPIO)-labeled cells appear as hypointense artifacts that obscure the underlying anatomy. The ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21399

    authors: Stuber M,Gilson WD,Schär M,Kedziorek DA,Hofmann LV,Shah S,Vonken EJ,Bulte JW,Kraitchman DL

    更新日期:2007-11-01 00:00:00

  • On multiple alternating steady states induced by periodic spin phase perturbation waveforms.

    abstract::Direct measurement of neural currents by means of MRI can potentially open a high temporal resolution (10-100 ms) window applicable for monitoring dynamics of neuronal activity without loss of the high spatial resolution afforded by MRI. Previously, we have shown that the alternating balanced steady state imaging affo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23105

    authors: Buračas GT,Jung Y,Lee J,Buxton RB,Wong EC,Liu TT

    更新日期:2012-05-01 00:00:00

  • Absolute oxygen tension (pO(2)) in murine fatty and muscle tissue as determined by EPR.

    abstract::The absolute partial pressure of oxygen (pO(2)) in the mammary gland pad and femoral muscle of female mice was measured using EPR oximetry at 700 MHz. A small quantity of lithium phthalocyanine (LiPc) crystals was implanted in both mammary and femoral muscle tissue of female C3H mice. Subsequent EPR measurements were ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20714

    authors: Matsumoto A,Matsumoto S,Sowers AL,Koscielniak JW,Trigg NJ,Kuppusamy P,Mitchell JB,Subramanian S,Krishna MC,Matsumoto K

    更新日期:2005-12-01 00:00:00

  • Iterative k-t principal component analysis with nonrigid motion correction for dynamic three-dimensional cardiac perfusion imaging.

    abstract:PURPOSE:In this study, an iterative k-t principal component analysis (PCA) algorithm with nonrigid frame-to-frame motion correction is proposed for dynamic contrast-enhanced three-dimensional perfusion imaging. METHODS:An iterative k-t PCA algorithm was implemented with regularization using training data corrected for...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24894

    authors: Schmidt JF,Wissmann L,Manka R,Kozerke S

    更新日期:2014-07-01 00:00:00

  • Improved MUSSELS reconstruction for high-resolution multi-shot diffusion weighted imaging.

    abstract:PURPOSE:MUSSELS is a one-step iterative reconstruction method for multishot diffusion weighted (msDW) imaging. The current work presents an efficient implementation, termed IRLS MUSSELS, that enables faster reconstruction to enhance its utility for high-resolution diffusion MRI studies. METHODS:The recently proposed M...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28090

    authors: Mani M,Aggarwal HK,Magnotta V,Jacob M

    更新日期:2020-06-01 00:00:00

  • Machine learning improves classification of preclinical models of pancreatic cancer with chemical exchange saturation transfer MRI.

    abstract:PURPOSE:We sought to assess whether machine learning-based classification approaches can improve the classification of pancreatic tumor models relative to more simplistic analysis methods, using T1 relaxation, CEST, and DCE MRI. METHODS:The T1 relaxation time constants, % CEST at five saturation frequencies, and vascu...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27439

    authors: Goldenberg JM,Cárdenas-Rodríguez J,Pagel MD

    更新日期:2019-01-01 00:00:00

  • A double echo ultra short echo time (UTE) acquisition for respiratory motion-suppressed high resolution imaging of the lung.

    abstract:PURPOSE:Magnetic resonance imaging is a promising alternative to computed tomography for lung imaging. However, organ motion and poor signal-to-noise ratio, arising from short T2*, impair image quality. To alleviate these issues, a new retrospective gating method was implemented and tested with an ultra-short echo time...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26891

    authors: Delacoste J,Chaptinel J,Beigelman-Aubry C,Piccini D,Sauty A,Stuber M

    更新日期:2018-04-01 00:00:00

  • New method for contrast manipulation in DNP-enhanced MRI.

    abstract::The magnetization subtraction technique (MS), which is equivalent to the inversion recovery technique in strong magnetic fields, has been implemented in dynamic nuclear polarization-enhanced magnetic resonance imaging (DNPI). The general theoretical basis of the MS method, which can be applied to DNPI or to prepolariz...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910350316

    authors: Planinsic G,Grucker D,Stepisnik J

    更新日期:1996-03-01 00:00:00

  • Analytical solution and verification of diffusion effect in SSFP.

    abstract::Assuming that the SSFP magnetization response maintains a steady state which is periodic in the presence of diffusion, we can solve for the diffusion effect in such sequences. Formulating a Fourier series decomposition solution to the Bloch-Torrey equation and imposing the steady-state condition, analytical expression...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910190209

    authors: Carney CE,Wong ST,Patz S

    更新日期:1991-06-01 00:00:00

  • Two-dimensional imaging in a lightweight portable MRI scanner without gradient coils.

    abstract:PURPOSE:As the premiere modality for brain imaging, MRI could find wider applicability if lightweight, portable systems were available for siting in unconventional locations such as intensive care units, physician offices, surgical suites, ambulances, emergency rooms, sports facilities, or rural healthcare sites. METH...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25147

    authors: Cooley CZ,Stockmann JP,Armstrong BD,Sarracanie M,Lev MH,Rosen MS,Wald LL

    更新日期:2015-02-01 00:00:00

  • NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-13 C2 ]glucose.

    abstract:PURPOSE:Image-guided prostate biopsies are routinely acquired in the diagnosis and treatment monitoring of prostate cancer, yielding useful tissue for identifying metabolic biomarkers and therapeutic targets. We developed an optimized biopsy tissue culture protocol in combination with [1,6-13 C2 ]glucose labeling and q...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27739

    authors: Bancroft Brown J,Sriram R,VanCriekinge M,Delos Santos R,Sun J,Delos Santos J,Tabatabai ZL,Shinohara K,Nguyen H,Peehl DM,Kurhanewicz J

    更新日期:2019-08-01 00:00:00

  • A comprehensive approach for correcting voxel-wise b-value errors in diffusion MRI.

    abstract:PURPOSE:In diffusion MRI, the actual b-value played out on the scanner may deviate from the nominal value due to magnetic field imperfections. A simple image-based correction method for this problem is presented. METHODS:The apparent diffusion constant (ADC) of a water phantom was measured voxel-wise along 64 diffusio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28078

    authors: Lee Y,Kettinger AO,Wilm BJ,Deichmann R,Weiskopf N,Lambert C,Pruessmann KP,Nagy Z

    更新日期:2020-06-01 00:00:00

  • Image reconstruction using a gradient impulse response model for trajectory prediction.

    abstract:PURPOSE:Gradient imperfections remain a challenge in MRI, especially for sequences relying on long imaging readouts. This work aims to explore image reconstruction based on k-space trajectories predicted by an impulse response model of the gradient system. THEORY AND METHODS:Gradient characterization was performed twi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25841

    authors: Vannesjo SJ,Graedel NN,Kasper L,Gross S,Busch J,Haeberlin M,Barmet C,Pruessmann KP

    更新日期:2016-07-01 00:00:00

  • Prospective multiaxial motion correction for fMRI.

    abstract::Corruption of the image time series due to interimage head motion limits the clinical utility of functional MRI. This paper presents a method for real-time prospective correction of rotation and translation in all six degrees of rigid body motion. By incorporating an orbital navigator (ONAV) echo for each of the sagit...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(200003)43:3<459::aid-mrm19

    authors: Ward HA,Riederer SJ,Grimm RC,Ehman RL,Felmlee JP,Jack CR Jr

    更新日期:2000-03-01 00:00:00

  • Intravoxel incoherent motion imaging using steady-state free precession.

    abstract::IVIM MR imaging is a method which generates images of diffusion and perfusion in vivo. Until now, intravoxel incoherent motion (IVIM) images have been obtained using spin-echo sequences with extragradient pulses, resulting in long acquisition times (typically 2 x 8 min 32 s). A new method is proposed here, using stead...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910070312

    authors: Le Bihan D

    更新日期:1988-07-01 00:00:00

  • Improved compressed sensing and super-resolution of cardiac diffusion MRI with structure-guided total variation.

    abstract:PURPOSE:Structure-guided total variation is a recently introduced prior that allows reconstruction of images using knowledge of the location and orientation of edges in a reference image. In this work, we demonstrate the advantages of a variant of structure-guided total variation known as directional total variation (D...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28245

    authors: Teh I,McClymont D,Carruth E,Omens J,McCulloch A,Schneider JE

    更新日期:2020-10-01 00:00:00

  • Self-degrading, MRI-detectable hydrogel sensors with picomolar target sensitivity.

    abstract::Nanostructured hydrogels have been developed as synthetic tissues and scaffolds for cell and drug delivery, and as guides for tissue regeneration. A fundamental problem in the development of synthetic hydrogels is that implanted gel structure is difficult to monitor noninvasively. This work demonstrates that the aggre...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22570

    authors: Colomb J,Louie K,Massia SP,Bennett KM

    更新日期:2010-12-01 00:00:00

  • Gadodiamide T1 relaxivity in brain tissue in vivo is lower than in saline.

    abstract::In vivo measurements of gadodiamide (Gd-DTPA-BMA) T(1) relaxivity were performed at 4.7 T in injured and normal rat brains. Cerebral lesions were induced in nine rats by a localized freezing method. T(1) maps of the lesions were generated before and after injection of Gd-DTPA-BMA (0.1-0.6 mmol/kg). Samples of normal a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20336

    authors: Pickup S,Wood AK,Kundel HL

    更新日期:2005-01-01 00:00:00

  • Localized proton MR spectroscopy of the human kidney in vivo by means of short echo time STEAM sequences.

    abstract::In order to obtain proton magnetic resonance spectra from the normal human kidney in vivo, we employed a STEAM sequence with delay times TE = 10 ms and TM = 30 ms. Signals are attenuated during STEAM sequences by J-coupling effects and by macroscopic movement of the sample. The combination of short echo times and resp...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310503

    authors: Dixon RM,Frahm J

    更新日期:1994-05-01 00:00:00

  • Multiclass imbalance learning: Improving classification of pediatric brain tumors from magnetic resonance spectroscopy.

    abstract:PURPOSE:Classification of pediatric brain tumors from 1 H-magnetic resonance spectroscopy (MRS) can aid diagnosis and management of brain tumors. However, varied incidence of the different tumor types leads to imbalanced class sizes and introduces difficulties in classifying rare tumor groups. This study assessed diffe...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26318

    authors: Zarinabad N,Wilson M,Gill SK,Manias KA,Davies NP,Peet AC

    更新日期:2017-06-01 00:00:00

  • Intimate combination of low- and high-resolution image data: I. Real-space PET and (1)H(2)O MRI, PETAMRI.

    abstract::Two different types of (co-registered) images of the same slice of tissue will generally have different spatial resolutions. The judicious pixel-by-pixel combination of their data can be accomplished to yield a single image exhibiting properties of both. Here, axial (18)FDG PET and (1)H(2)O MR images of the human brai...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199908)42:2<345::aid-mrm17

    authors: Sammi MK,Felder CA,Fowler JS,Lee JH,Levy AV,Li X,Logan J,Pályka I,Rooney WD,Volkow ND,Wang GJ,Springer CS Jr

    更新日期:1999-08-01 00:00:00

  • Transcatheter intra-arterial perfusion (TRIP)-MRI biomarkers help detect immediate response to irreversible electroporation of rabbit VX2 liver tumor.

    abstract:PURPOSE:Irreversible electroporation (IRE) is a nonthermal tissue ablation technique that represents a promising treatment option for unresectable liver tumors, but the effectively treated zone cannot be reliably predicted. We investigate the potential benefit of transcatheter intra-arterial perfusion (TRIP) -MRI for t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28104

    authors: Figini M,Zhou K,Pan L,Sun C,Wang B,Hu S,Yang J,Shangguan J,Eresen A,Velichko Y,Yaghmai V,Zhang Z

    更新日期:2020-07-01 00:00:00