Self-degrading, MRI-detectable hydrogel sensors with picomolar target sensitivity.

Abstract:

:Nanostructured hydrogels have been developed as synthetic tissues and scaffolds for cell and drug delivery, and as guides for tissue regeneration. A fundamental problem in the development of synthetic hydrogels is that implanted gel structure is difficult to monitor noninvasively. This work demonstrates that the aggregation of magnetic nanoparticles, attached to specific macromolecules in biological and synthetic hydrogels, can be controlled to detect changes in gel macromolecular structure with MRI. It is further shown that the gels can be made to self-degrade when they come into contact with a target molecule in as low as pM concentrations. The sensitivity of the gels to the target is finely controlled using an embedded zymogen cascade amplifier. These "MRI reporter gels" may serve as smart, responsive polymer implants, as tissue scaffolds to deliver drugs, or to detect specific pathogens in vivo.

journal_name

Magn Reson Med

authors

Colomb J,Louie K,Massia SP,Bennett KM

doi

10.1002/mrm.22570

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1792-9

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

64

pub_type

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