Evaluation of multicontrast MRI including fat suppression and inversion recovery spin echo for identification of intra-plaque hemorrhage and lipid core in human carotid plaque using the mahalanobis distance measure.


:Intra-plaque hemorrhage (IPH) and lipid core, characteristics of rupture prone carotid plaques, are often visualized in vivo with MRI using T1 weighted gradient and spin echo, respectively. Increasing magnetic field strength may help to identify IPH and lipid core better. As a proof of concept, automatic segmentation of plaque components was performed with the Mahalanobis distance (MD) measure derived from image contrast from multicontrast MR images including inversion recovery spin echo and T1 weighted gradient echo with fat suppression. After MRI of nine formaldehyde-fixated autopsy specimens, the MDs and Euclidean Distances between plaque component intensities were calculated for each MR weighting. The distances from the carotid bifurcation and the size and shape of calcification spots were used as landmarks for coregistration of MRI and histology. MD between collagen/cell-rich area and IPH was largest with inversion recovery spin echo (4.2/9.3, respectively), between collagen/cell-rich area/foam cells and lipid core with T1 weighted gradient echo with fat suppression (26.9/38.2/4.6, respectively). The accuracy of detection of IPH, cell-rich area, and collagen increased when the MD classifier was used compared with the Euclidean Distance classifier. The enhanced conspicuity of lipid core and IPH in human carotid artery plaque, using ex vivo T1 weighted gradient echo with fat suppression and inversion recovery spin echo MRI and MD classifiers, demands further in vivo evaluation in patients.


Magn Reson Med


te Boekhorst BC,van 't Klooster R,Bovens SM,van de Kolk KW,Cramer MJ,van Oosterhout MF,Doevendans PA,van der Geest RJ,Pasterkamp G,van Echteld CJ




Has Abstract


2012-06-01 00:00:00












  • A double-tuned probe for metabolic NMR studies.

    abstract::A double-tuned single coil probe for high field metabolic NMR studies has been designed and tested. The resonant coil is a single-turn of copper foil wound on a quartz cylinder. It is fed by a short length of parallel strip line made of the same material; the feeder is also used as a tuning capacitance. Electrical par...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Najim E,Grivet JP

    更新日期:1992-02-01 00:00:00

  • Histogram analysis of the microvasculature of intracerebral human and murine glioma xenografts.

    abstract::The purpose of this study is to examine the usefulness of histogram analysis combined with vessel size index (VSI) magnetic resonance imaging for the specific characterization of brain tumor microvasculature in a panel of six volume-matched glioma xenografts. Using a simple descriptive histogram analysis, significant ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Just N

    更新日期:2011-03-01 00:00:00

  • Investigation of a whole-body receiver coil operating at liquid nitrogen temperatures.

    abstract::This communication describes the design and application of a receiver coil operating at liquid nitrogen temperature and intended as a surface coil in a whole-body imager. Its particular application is seen as the external receiver for parasitic internal or implanted detectors. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hall AS,Barnard B,McArthur P,Gilderdale DJ,Young IR,Bydder GM

    更新日期:1988-06-01 00:00:00

  • In vivo whole-blood T2 versus HbO2 calibration by modulating blood oxygenation level in the femoral vein through intermittent cuff occlusion.

    abstract:PURPOSE:To investigate the feasibility of estimating calibration constants (K and T2o ) in vivo for converting whole-blood T2 to blood hemoglobin oxygen saturation (HbO2 ) according to the Luz-Meiboom model, 1/T2=1/T2o+K(1-HbO2)2, where K and T2o are relaxivity and transverse relaxation time of fully saturated blood, r...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Langham MC,Rodríguez-Soto AE,Schwartz N,Wehrli FW

    更新日期:2018-04-01 00:00:00

  • MR angiography by selective inversion recovery.

    abstract::A modified inversion-recovery sequence is introduced which performs subtraction angiography by varying time-of-flight effects of blood flowing into an imaged slab. The selective 180 degrees excitation inverts different regions between measurements to isolate arterial and/or venous blood. On normal human subjects, high...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Nishimura DG,Macovski A,Pauly JM,Conolly SM

    更新日期:1987-02-01 00:00:00

  • Murine orthostatic response during prolonged vertical studies: effect on cerebral blood flow measured by arterial spin-labeled MRI.

    abstract::High-field MRI scanners are, in principle, well suited for mouse studies; however, many high-field magnets employ a vertical design that may influence the physiological state of the rodent. The purpose of this study was to investigate the orthostatic response of cerebral blood flow (CBF) in mice during a prolonged MR ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Foley LM,Hitchens TK,Kochanek PM,Melick JA,Jackson EK,Ho C

    更新日期:2005-10-01 00:00:00

  • Transverse relaxivity of iron oxide nanocrystals clustered in nanoemulsions: Experiment and theory.

    abstract:PURPOSE:To compare experimental transverse relaxivities of iron oxide nanocrystals (IONC) as a function of clustering and magnetic field strength with different theoretical model predictions. THEORY AND METHODS:Well-defined IONC clusters in nanoemulsions (NEs) of which both size and IONC loading could be judiciously t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hak S,Goa PE,Stenmark S,Bjerkholt FF,Haraldseth O

    更新日期:2015-09-01 00:00:00

  • Metabolite 1H relaxation in normal and hyponatremic brain.

    abstract::Proton spin relaxation rate constants in normal and hyponatremic rat brain were measured to determine the sensitivity of metabolite relaxation properties to cytotoxic edema and to quantify metabolite concentration in normal and edematous brain. Relaxation rate constants for protons of water and spectral regions with d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Rooney WD,Ebisu T,Mancuso A,Graham S,Weiner MW,Maudsley AA

    更新日期:1996-05-01 00:00:00

  • On the signal-to-noise ratio benefit of spiral acquisition in diffusion MRI.

    abstract:PURPOSE:Spiral readouts combine several favorable properties that promise superior net sensitivity for diffusion imaging. The purpose of this study is to verify the signal-to-noise ratio (SNR) benefit of spiral acquisition in comparison with current echo-planar imaging (EPI) schemes. METHODS:Diffusion-weighted in vivo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Lee Y,Wilm BJ,Brunner DO,Gross S,Schmid T,Nagy Z,Pruessmann KP

    更新日期:2021-04-01 00:00:00

  • Quantification of fluid changes in rat leg joints with adjuvant arthritis by a one-dimensional magnetic resonance imaging experiment.

    abstract::A simple and reliable method for quantifying the fluid content and characterizing the tissue T2 relaxation properties of animal extremities has been devised. This one-dimensional magnetic resonance imaging experiment, applied to the adjuvant arthritis model in rats, provides a useful, noninvasive monitor of the course...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Borah B,Szeverenyi NM

    更新日期:1990-08-01 00:00:00

  • Intersubject specific absorption rate variability analysis through construction of 23 realistic body models for prostate imaging at 7T.

    abstract:PURPOSE:For ultrahigh field (UHF) MRI, the expected local specific absorption rate (SAR) distribution is usually calculated by numerical simulations using a limited number of generic body models and adding a safety margin to take into account intersubject variability. Assessment of this variability with a large model d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Meliadò EF,van den Berg CAT,Luijten PR,Raaijmakers AJE

    更新日期:2019-03-01 00:00:00

  • Delay and dispersion effects in dynamic susceptibility contrast MRI: simulations using singular value decomposition.

    abstract::Dynamic susceptibility contrast (DSC) MRI is now increasingly used for measuring perfusion in many different applications. The quantification of DSC data requires the measurement of the arterial input function (AIF) and the deconvolution of the tissue concentration time curve. One of the most accepted deconvolution me...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Calamante F,Gadian DG,Connelly A

    更新日期:2000-09-01 00:00:00

  • Fast, three-dimensional free-breathing MR imaging of myocardial infarction: a feasibility study.

    abstract::Imaging delayed hyperenhancement of myocardial infarction is most commonly performed using an inversion recovery (IR) prepared 2D breathhold segmented k-space gradient echo (FGRE) sequence. Since only one slice is acquired per breathhold in this technique, 12-16 successive breathholds are required for complete anatomi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Saranathan M,Rochitte CE,Foo TK

    更新日期:2004-05-01 00:00:00

  • Echo-planar spin-echo and inversion pulses.

    abstract::The echo-planar k-space trajectory can be used as the basis for any two-dimensional selective pulse. The main application is spectral-spatial pulses, which must be based on the echo-planar trajectory. In this paper we show how echo-planar spin-echo (EPSE) pulses may be designed. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Pauly J,Spielman D,Macovski A

    更新日期:1993-06-01 00:00:00

  • More accurate estimation of diffusion tensor parameters using diffusion Kurtosis imaging.

    abstract::With diffusion tensor imaging, the diffusion of water molecules through brain structures is quantified by parameters, which are estimated assuming monoexponential diffusion-weighted signal attenuation. The estimated diffusion parameters, however, depend on the diffusion weighting strength, the b-value, which hampers t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Veraart J,Poot DH,Van Hecke W,Blockx I,Van der Linden A,Verhoye M,Sijbers J

    更新日期:2011-01-01 00:00:00

  • Perfusion mapping with multiecho multishot parallel imaging EPI.

    abstract::Echo-planar imaging (EPI) is the standard technique for dynamic susceptibility-contrast (DSC) perfusion MRI. However, EPI suffers from well-known geometric distortions, which can be reduced by increasing the k-space phase velocity. Moreover, the long echo times (TEs) used in DSC lead to signal saturation of the arteri...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Newbould RD,Skare ST,Jochimsen TH,Alley MT,Moseley ME,Albers GW,Bammer R

    更新日期:2007-07-01 00:00:00

  • Improved sensitivity to overlapping multiplet signals in in vivo proton spectroscopy using a multiecho volume selective (CPRESS) experiment.

    abstract::A method for volume selective proton spectroscopy is presented based on a multiecho sequence with short refocusing interval tcp. It is demonstrated, that by appropriate choice of tcp on the order of 4-6 ms, signals from overlapping multiplets like the glutamine and glutamate (Glu/Gln) resonances in spectra of the huma...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hennig J,Thiel T,Speck O

    更新日期:1997-06-01 00:00:00

  • Resolution-recovery for EPR imaging of free radical molecules in mice.

    abstract::A method of post-processing to enhance the image resolution of the distribution of free radical molecules obtained with continuous-wave electron paramagnetic resonance (CW-EPR) imaging is reported. The low spatial resolution of EPR imaging, which has created difficulties in biomedical applications, was overcome by the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Ikebata Y,Sato-Akaba H,Aoyama T,Fujii H,Itoh K,Hirata H

    更新日期:2009-09-01 00:00:00

  • Safety and technique of ferumoxytol administration for MRI.

    abstract::Ferumoxytol is an ultrasmall superparamagnetic iron oxide agent marketed for the treatment of anemia. There has been increasing interest in its properties as an MRI contrast agent as well as greater awareness of its adverse event profile. This mini-review summarizes the current state of knowledge of the risks of ferum...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,评审


    authors: Vasanawala SS,Nguyen KL,Hope MD,Bridges MD,Hope TA,Reeder SB,Bashir MR

    更新日期:2016-05-01 00:00:00

  • Polymer thick film technology for improved simultaneous dEEG/MRI recording: Safety and MRI data quality.

    abstract:PURPOSE:To develop a 256-channel dense-array electroencephalography (dEEG) sensor net (the Ink-Net) using high-resistance polymer thick film (PTF) technology to improve safety and data quality during simultaneous dEEG/MRI. METHODS:Heating safety was assessed with temperature measurements in an anthropomorphic head pha...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Poulsen C,Wakeman DG,Atefi SR,Luu P,Konyn A,Bonmassar G

    更新日期:2017-02-01 00:00:00

  • Three-dimensional MRI with independent slab excitation and encoding.

    abstract::Three-dimensional MRI is typically performed with the same orientation for radiofrequency slab excitation and slab select phase encoding. We introduce independent slab excitation and encoding to create a new degree of freedom in three-dimensional MRI, which is the angular relationship between the prescribed excitation...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Eissa A,Wilman AH

    更新日期:2012-02-01 00:00:00

  • Multi-band MR fingerprinting (MRF) ASL imaging using artificial-neural-network trained with high-fidelity experimental data.

    abstract:PURPOSE:We aim to leverage the power of deep-learning with high-fidelity training data to improve the reliability and processing speed of hemodynamic mapping with MR fingerprinting (MRF) arterial spin labeling (ASL). METHODS:A total of 15 healthy subjects were studied on a 3T MRI. Each subject underwent 10 runs of a m...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Fan H,Su P,Huang J,Liu P,Lu H

    更新日期:2021-04-01 00:00:00

  • An analytical solution to the dispersion-by-inversion problem in magnetic resonance elastography.

    abstract:PURPOSE:Magnetic resonance elastography (MRE) measures stiffness of soft tissues by analyzing their spatial harmonic response to externally induced shear vibrations. Many MRE methods use inversion-based reconstruction approaches, which invoke first- or second-order derivatives by finite difference operators (first- and...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Mura J,Schrank F,Sack I

    更新日期:2020-07-01 00:00:00

  • Diffusion imaging of the spinal cord in vivo: estimation of the principal diffusivities and application to multiple sclerosis.

    abstract::Magnetic resonance (MR) diffusion imaging is a useful technique with which to increase our understanding of pathologic damage to the central nervous system. To fully quantitate diffusion and anisotropy in the spinal cord, as in other tissues, it is necessary to determine the diffusion tensor. If spinal cord diffusion ...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章


    authors: Clark CA,Werring DJ,Miller DH

    更新日期:2000-01-01 00:00:00

  • Quantitative 1 H MRI and MRS of fatty acid composition.

    abstract::Adipose tissue as well as other depots of fat (triglycerides) are increasingly being recognized as active contributors to the human function and metabolism. In addition to the fat concentration, also the fatty acid chemical composition (FAC) of the triglyceride molecules may play an important part in diseases such as ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,评审


    authors: Peterson P,Trinh L,Månsson S

    更新日期:2021-01-01 00:00:00

  • A unique anisotropic R2 of collagen degeneration (ARCADE) mapping as an efficient alternative to composite relaxation metric (R2 -R1 ρ ) in human knee cartilage study.

    abstract:PURPOSE:Anisotropic transverse R2 (1/T2 ) relaxation of water proton is sensitive to cartilage degenerative changes. The purpose is to develop an efficient method to extract this relaxation metric in clinical studies. METHODS:Anisotropic R2 can be measured inefficiently by standard R2 mapping after removing an isotrop...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Pang Y,Palmieri-Smith RM,Malyarenko DI,Swanson SD,Chenevert TL

    更新日期:2019-06-01 00:00:00

  • Design of adiabatic selective pulses using optimal control theory.

    abstract::Optimal control theory has been applied in the past for the design of RF pulses for selective excitation. This was the outcome of having established the controllability of the MR spin system for the selective excitation problem. "Minimum distance" was the main formulation used for the solution. Because of their robust...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Rosenfeld D,Zur Y

    更新日期:1996-09-01 00:00:00

  • Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism.

    abstract:PURPOSE:The diseased myocardium lacks metabolic flexibility and responds to stimuli differently compared with healthy hearts. Here, we report the use of hyperpolarized 13C NMR spectroscopy to detect sudden changes in cardiac metabolism in isolated, perfused rat hearts in response to adrenergic stimulation. METHODS:Met...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Khemtong C,Carpenter NR,Lumata LL,Merritt ME,Moreno KX,Kovacs Z,Malloy CR,Sherry AD

    更新日期:2015-08-01 00:00:00

  • On the origin of paramagnetic inhomogeneity effects in blood.

    abstract::Hydrogen, sodium, and fluorine (added F-) NMR spectra of venous and oxygenated blood were measured. The fluorine resonance was seen as a single peak in both samples, and all three resonances exhibited the same deoxy-oxy shift. Because F- exchanges slowly across the red cell membrane, and because sodium is 95% extracel...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Brooks RA,Brunetti A,Alger JR,Di Chiro G

    更新日期:1989-11-01 00:00:00

  • Motion correction in fMRI via registration of individual slices into an anatomical volume.

    abstract::An automated retrospective image registration based on mutual information is adapted to a multislice functional magnetic resonance imaging (fMRI) acquisition protocol to provide accurate motion correction. Motion correction is performed by mapping each slice to an anatomic volume data set acquired in the same fMRI ses...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Kim B,Boes JL,Bland PH,Chenevert TL,Meyer CR

    更新日期:1999-05-01 00:00:00