Abstract:
PURPOSE:To evaluate proton density fat fraction (PDFF) and R2* as markers of bone marrow composition and structure in inflamed bone in patients with spondyloarthritis. METHODS:Phantoms containing fat, water, and trabecular bone were constructed with proton density fat fraction (PDFF) and bone mineral density (BMD) values matching those expected in healthy bone marrow and disease states, and scanned using chemical shift-encoded MRI (CSE-MRI) at 3T. Measured PDFF and R2* values in phantoms were compared with reference FF and BMD values. Eight spondyloarthritis patients and 10 controls underwent CSE-MRI of the sacroiliac joints. PDFF and R2* in areas of inflamed bone and fat metaplasia in patients were compared with normal bone marrow in controls. RESULTS:In phantoms, PDFF measurements were accurate over the full range of PDFF and BMD values. R2* measurements were positively associated with BMD but also were influenced by variations in PDFF. In patients, PDFF was reduced in areas of inflammation and increased in fat metaplasia compared to normal marrow. R2* measurements were significantly reduced in areas of fat metaplasia. CONCLUSION:PDFF measurements reflect changes in marrow composition in areas of active inflammation and structural damage and could be used for disease monitoring in spondyloarthritis. R2* measurements may provide additional information bone mineral density but also are influenced by fat content. Magn Reson Med 79:1031-1042, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Bray TJP,Bainbridge A,Punwani S,Ioannou Y,Hall-Craggs MAdoi
10.1002/mrm.26729subject
Has Abstractpub_date
2018-02-01 00:00:00pages
1031-1042issue
2eissn
0740-3194issn
1522-2594journal_volume
79pub_type
杂志文章abstract:PURPOSE:To assess the impact of a different distortion correction (DC) method and patient geometry (sagittal balance) on the quality of spinal cord tractography rendering according to different tractography approaches. METHODS:Forty-four adults free of spinal cord diseases underwent cervical diffusion-weighted imaging...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28665
更新日期:2021-01-21 00:00:00
abstract::Acute normovolemic hemodilution (HD) was induced in anesthetized rats to assess the effect of changes in hematocrit (Hct) on signal intensity in T2*-weighted magnetic resonance (MR) images. Other relevant physiological parameters were maintained invariant. Two degrees of HD were induced: mild (Hct reduced from 42.6+/-...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910400611
更新日期:1998-12-01 00:00:00
abstract::Accurate and fast quantification of myocardial blood flow (MBF) with MR first-pass perfusion imaging techniques on a pixel-by-pixel basis remains difficult due to relatively long calculation times and noise-sensitive algorithms. In this study, Zierler's central volume principle was used to develop an algorithm for the...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21559
更新日期:2008-06-01 00:00:00
abstract::This work presents a method that allows for the assessment of 3D murine myocardial motion in vivo at microscopic resolution. Phase-contrast (PC) magnetic resonance imaging (MRI) at 17.6 T was applied to map myocardial motion in healthy mice along three gradient directions. High-resolution velocity maps were acquired a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20866
更新日期:2006-05-01 00:00:00
abstract::This note considers the anomolous contrast in inversion recovery images produced by NMR scanners if a map of [My] is reconstructed, rather than a map of My'. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910020110
更新日期:1985-02-01 00:00:00
abstract::Proton spin relaxation rate constants in normal and hyponatremic rat brain were measured to determine the sensitivity of metabolite relaxation properties to cytotoxic edema and to quantify metabolite concentration in normal and edematous brain. Relaxation rate constants for protons of water and spectral regions with d...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350510
更新日期:1996-05-01 00:00:00
abstract::The previously reported concept for quantitative magnetization transfer (MT) imaging using balanced steady-state free precession (SSFP) is applied to nonbalanced SSFP sequences. This offers the possibility to derive quantitative MT parameters of targets with high-susceptibility variations such as the musculoskeletal s...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22331
更新日期:2010-07-01 00:00:00
abstract::Iron-mediated tissue damage is present in cerebrovascular and neurodegenerative diseases and neurotrauma. Brain microbleeds are often present in these maladies and are assuming increasing clinical importance. Because brain microbleeds present a source of pathologic iron to the brain, the noninvasive quantification of ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22185
更新日期:2010-01-01 00:00:00
abstract::A new parallel imaging technique was implemented which can result in reduced image acquisition times in MRI. MR data is acquired in parallel using an array of receiver coils and then reconstructed simultaneously with multiple processors. The method requires the initial estimation of the 2D sensitivity profile of each ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200008)44:2<301::aid-mrm18>3.0.c
更新日期:2000-08-01 00:00:00
abstract::The concept of temporal echo multiplexing is defined and used to develop rapid biphasic spin-echo sequences for imaging the heart. Three imaging sequences, based on four-echo and two-echo multiplexing and rapid single echo (i.e., conventional spin-echo imaging), are compared. Preliminary results indicate that two-echo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910110109
更新日期:1989-07-01 00:00:00
abstract::Two single-shot volume imaging techniques are described. The first, single-echo echo-volume imaging, is essentially the echo-volume imaging (EVI) sequence suggested by Mansfield (J. Phys. C. 10, L55 (1977)). The second is a multi-spin-echo approach in which one plane of k-space is collected during each spin echo. In b...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910320518
更新日期:1994-11-01 00:00:00
abstract::In proton magnetic resonance imaging (MRI) metallic substances lead to magnetic field distortions that often result in signal voids in the adjacent anatomic structures. Thus, metallic objects and superparamagnetic iron oxide (SPIO)-labeled cells appear as hypointense artifacts that obscure the underlying anatomy. The ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21399
更新日期:2007-11-01 00:00:00
abstract:PURPOSE:To evaluate the role of true diffusion and flow-related pseudodiffusion in cerebral blood flow (CBF) quantification using arterial spin labeling (ASL) with single-shot or segmented 3D gradient and spin echo (GRASE) readouts. THEORY:The extended phase graph (EPG) algorithm, originally designed to model the effe...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27058
更新日期:2018-08-01 00:00:00
abstract::To investigate white matter (WM) development, voxelwise analyses of diffusion tensor MRI (DTMRI) data, acquired from 12 very preterm and 11 preterm infants with gestational ages (GA) ranging from 25 to 29 and 29 to 32 weeks, respectively, and 10 newborn normal term infants were performed. T(2) relaxation measures were...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21689
更新日期:2008-10-01 00:00:00
abstract::Magnetic resonance (MR) imaging and relaxation time measurements of bioresorbable implants made of polylactic acid (PLA), as well as the surrounding tissues, were carried out over a period of 6 months to monitor the implant state and the body's responses, and to determine how these processes are reflected in MR data. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199907)42:1<210::aid-mrm29
更新日期:1999-07-01 00:00:00
abstract::A precise understanding of human blood spin-spin relaxation is of major importance for numerous applications, particularly functional magnetic resonance imaging (fMRI), which is increasingly performed at 3 Tesla. It is well known that T2 measured from partially deoxygenated blood depends on the Carr-Purcell Meiboom-Gi...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21858
更新日期:2009-02-01 00:00:00
abstract::Measurements of the volume magnetic susceptibility of solids using the classical Gouy balance approach are hampered by variations in apparent density of the packed powder. In this paper a quantitative NMR measurement of the volume magnetic susceptibility of powdered solids is described and the volume susceptibility of...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910370404
更新日期:1997-04-01 00:00:00
abstract::A multiple quantum filter strategy is presented for spectrally discriminating metabolites with strongly coupled spins from those whose spins are either uncoupled or weakly coupled. The strategy also includes a means for selectively suppressing the background multiplets of metabolites that also have strongly coupled sp...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10697
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:To develop and evaluate a novel two-dimensional self-gated imaging technique for free-breathing cardiac cine MRI that is free of motion-detection overhead and requires minimal planning for motion tracking. METHODS:Motion along the readout direction was extracted solely from normal Cartesian imaging readouts ne...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25834
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To verify MR measurements of myocardial extracellular volume fraction (ECV) based on clinically applicable T1-mapping sequences against ECV measurements by radioisotope tracer in pigs and to relate the results to those obtained in volunteers. METHODS:Between May 2016 and March 2017, 8 volunteers (25 ± 4 years,...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27938
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:Dynamic glucose-enhanced (DGE)-MRI based on chemical exchange-sensitive MRI, that is, glucoCEST and gluco-chemical exchange-sensitive spin-lock (glucoCESL), is intrinsically prone to motion-induced artifacts because the final DGE contrast relies on the difference of images, which were acquired with a time gap o...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28112
更新日期:2020-07-01 00:00:00
abstract::A demonstration of MR guided thermal surgery involved experiments with imaging of focused ultrasound in an MRI system, measurements of the thermal transients and a thermal analysis of the resulting images. Both the heat distribution and the creation of focused ultrasound lesions in gel phantoms, in vitro bovine muscle...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910300115
更新日期:1993-07-01 00:00:00
abstract:PURPOSE:To design short parallel transmission (pTx) pulses for excitation of arbitrary three-dimensional (3D) magnetization patterns. METHODS:We propose a joint optimization of the pTx radiofrequency (RF) and gradient waveforms for excitation of arbitrary 3D magnetization patterns. Our optimization of the gradient wav...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26021
更新日期:2016-10-01 00:00:00
abstract::A 3-T study is presented, comparing the ability of two (1) H spectroscopy pulse sequences, Carr-Purcell point resolved spectroscopy (CPRESS; TE = 45 msec), and conventional PRESS (TE = 35 msec), to separate between groups of 20 normal control (NC) and 20 mild cognitive impairment (MCI) subjects. Both sequences showed ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22749
更新日期:2011-06-01 00:00:00
abstract::The protocol for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was adapted for the evaluation of transplanted osteochondral allograft cartilage. Eight patients with focal grade 4 cartilage defects of the femoral condyle were treated with single cylindrical osteochondral allografts. At 1 and 2 years, dGEMRIC i...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/mrm.24419
更新日期:2013-06-01 00:00:00
abstract::Functional MRI (fMRI) was used to assess proprioceptive-associated cervical cord activity in 24 relapsing multiple sclerosis (MS) patients and 10 controls. Cord and brain conventional and diffusion tensor (DT) MRI were also acquired. fMRI was performed using a block design during a proprioceptive stimulation consistin...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21595
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:To develop a framework for respiratory motion-corrected 3D whole-heart water/fat coronary MR angiography (CMRA) at 3T with reduced and predictable scan time. METHODS:A 3D dual-echo acquisition and respiratory motion-corrected reconstruction framework for water/fat CMRA imaging was developed. The acquisition se...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27732
更新日期:2019-08-01 00:00:00
abstract::In vivo lactate detection using gradient enhanced double quantum coherence transfer (DQCT) was significantly improved by addition of short-time-inversion-recovery (STIR). Phantom studies demonstrated lipid suppression down to the background noise level with 33% loss of lactate signal. In vivo studies using a rabbit mo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910400416
更新日期:1998-10-01 00:00:00
abstract::It is shown that the effect of pH changes can be measured in proton NMR spectra through the pH sensitivity of the signal intensities of metabolite protons exchanging with water. To observe this phenomenon, pulse sequences must be used that can sensitively observe these exchangeable protons under physiological conditio...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910400105
更新日期:1998-07-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) has recently been adopted as an investigational tool in the field of neuroscience. The signal changes induced by brain activations are small ( approximately 1-2%) at 1.5T. Therefore, the signal-to-noise ratio (SNR) of the time series used to calculate the functional maps is...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200012)44:6<925::aid-mrm14>3.0.c
更新日期:2000-12-01 00:00:00