Strategy for lipid suppression in lactate imaging using STIR-DQCT: a study of hypoxic-ischemic brain injury.

Abstract:

:In vivo lactate detection using gradient enhanced double quantum coherence transfer (DQCT) was significantly improved by addition of short-time-inversion-recovery (STIR). Phantom studies demonstrated lipid suppression down to the background noise level with 33% loss of lactate signal. In vivo studies using a rabbit model of hypoxic and unilateral-ischemic brain injury showed reduction down to 29 +/- 11% in lipids with inversion times between 140 and 170 ms. Lactate signals on the ischemic side were 51 +/- 53% higher than the nonischemic side at the peak of hypoxia. STIR-DQCT can be a useful robust method of obtaining metabolic maps of lactate in vivo.

journal_name

Magn Reson Med

authors

Nakai T,Rhine WD,Okada T,Stevenson DK,Spielman DM

doi

10.1002/mrm.1910400416

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

629-32

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

40

pub_type

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