Abstract:
:In this work, a new double quantum filter for glutathione (GSH) editing is introduced, combined with the point-resolved spectroscopy localization sequence (PRESS), and demonstrated in vivo. Compared to the conventional double quantum coherence filter, the new filter has two major advantages. First, it eliminates the need for calibration scans for optimizing the signal yield, making it more efficient and convenient for routine use. Second, it removes the influence of water saturation pulses on the GSH yield, further improving its accuracy. With this method, GSH concentrations in the left and right parietal lobes of five healthy volunteers were determined to be 0.91+/-0.16 mM and 0.89+/-0.16 mM, respectively, in agreement with previous studies.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Zhao T,Heberlein K,Jonas C,Jones DP,Hu Xdoi
10.1002/mrm.20788subject
Has Abstractpub_date
2006-03-01 00:00:00pages
676-80issue
3eissn
0740-3194issn
1522-2594journal_volume
55pub_type
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