New double quantum coherence filter for localized detection of glutathione in vivo.

Abstract:

:In this work, a new double quantum filter for glutathione (GSH) editing is introduced, combined with the point-resolved spectroscopy localization sequence (PRESS), and demonstrated in vivo. Compared to the conventional double quantum coherence filter, the new filter has two major advantages. First, it eliminates the need for calibration scans for optimizing the signal yield, making it more efficient and convenient for routine use. Second, it removes the influence of water saturation pulses on the GSH yield, further improving its accuracy. With this method, GSH concentrations in the left and right parietal lobes of five healthy volunteers were determined to be 0.91+/-0.16 mM and 0.89+/-0.16 mM, respectively, in agreement with previous studies.

journal_name

Magn Reson Med

authors

Zhao T,Heberlein K,Jonas C,Jones DP,Hu X

doi

10.1002/mrm.20788

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

676-80

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

55

pub_type

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