Accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 Tesla.

Abstract:

:MRI has become an important tool to noninvasively assess global and regional cardiac function, infarct size, or myocardial blood flow in surgically or genetically modified mouse models of human heart disease. Constraints on scan time due to sensitivity to general anesthesia in hemodynamically compromised mice frequently limit the number of parameters available in one imaging session. Parallel imaging techniques to reduce acquisition times require coil arrays, which are technically challenging to design at ultrahigh magnetic field strengths. This work validates the use of an eight-channel volume phased-array coil for cardiac MRI in mice at 9.4 T. Two- and three-dimensional sequences were combined with parallel imaging techniques and used to quantify global cardiac function, T(1)-relaxation times and infarct sizes. Furthermore, the rapid acquisition of functional cine-data allowed for the first time in mice measurement of left-ventricular peak filling and ejection rates under intravenous infusion of dobutamine. The results demonstrate that a threefold accelerated data acquisition is generally feasible without compromising the accuracy of the results. This strategy may eventually pave the way for routine, multiparametric phenotyping of mouse hearts in vivo within one imaging session of tolerable duration.

journal_name

Magn Reson Med

authors

Schneider JE,Lanz T,Barnes H,Stork LA,Bohl S,Lygate CA,Ordidge RJ,Neubauer S

doi

10.1002/mrm.22605

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

60-70

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

65

pub_type

杂志文章
  • Ifosfamide pharmacokinetics and hepatobiliary uptake in vivo investigated using single- and double-resonance 31P MRS.

    abstract::MRS has considerable potential for the measurement of drug pharmacokinetics in vivo. In this study single- and double-resonance (31)P MRS was used to investigate the biodistribution, pharmacokinetics, and metabolism of ifosfamide following administration of 500 mg/kg ifosfamide in guinea pigs. (1)H-decoupling was foun...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10540

    authors: Mancini L,Payne GS,Dzik-Jurasz AS,Leach MO

    更新日期:2003-08-01 00:00:00

  • Measurement of changes in cerebral blood volume in spontaneously hypertensive rats following L-arginine infusion using dynamic susceptibility contrast MRI.

    abstract::To understand whether the NO-dependent vasodilator L-arginine was effective upon a chronically hypertensive cerebral capillary endothelium, dynamic susceptibility contrast MRI was used to measure the relative cerebral blood volume (rCBV) changes in nonischemic spontaneously hypertensive rats (SHRs). rCBV was measured ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910390123

    authors: Caramia F,Yoshida T,Hamberg LM,Huang Z,Hunter G,Wanke I,Zaharchuk G,Moskowitz MA,Rosen BR

    更新日期:1998-01-01 00:00:00

  • Characterizing the limits of MRI near metallic prostheses.

    abstract:PURPOSE:To characterize the fundamental limits of MRI near metallic implants on RF excitation, frequency encoding, and chemical shift-encoding water-fat separation. METHODS:Multicomponent three-dimensional (3D) digital models of a total hip and a total knee replacement were used to construct material-specific suscepti...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25540

    authors: Smith MR,Artz NS,Wiens C,Hernando D,Reeder SB

    更新日期:2015-12-01 00:00:00

  • Multidimensionally encoded magnetic resonance imaging.

    abstract::Magnetic resonance imaging (MRI) typically achieves spatial encoding by measuring the projection of a q-dimensional object over q-dimensional spatial bases created by linear spatial encoding magnetic fields (SEMs). Recently, imaging strategies using nonlinear SEMs have demonstrated potential advantages for reconstruct...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24443

    authors: Lin FH

    更新日期:2013-07-01 00:00:00

  • PLANET: An ellipse fitting approach for simultaneous T1 and T2 mapping using phase-cycled balanced steady-state free precession.

    abstract:PURPOSE:To demonstrate the feasibility of a novel, ellipse fitting approach, named PLANET, for simultaneous estimation of relaxation times T1 and T2 from a single 3D phase-cycled balanced steady-state free precession (bSSFP) sequence. METHODS:A method is presented in which the elliptical signal model is used to descri...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26717

    authors: Shcherbakova Y,van den Berg CAT,Moonen CTW,Bartels LW

    更新日期:2018-02-01 00:00:00

  • A versatile multinuclear probe designed for in vivo NMR spectroscopy: applications to subcutaneous human tumors in mice.

    abstract::We describe a versatile NMR probe that is designed for a variety of in vivo spectroscopic studies on small animals in vertical wide-bore magnets. Replaceable brackets enable the coils to be exchanged readily in order to observe 1H, 13C, 31P, and other nuclei, and to carry out double-resonance experiments. Two solenoid...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910060102

    authors: Lyon RC,Tschudin RG,Daly PF,Cohen JS

    更新日期:1988-01-01 00:00:00

  • Accelerated J-resolved 1 H-MRSI with limited and sparse sampling of ( k , t 1 , t 2 -space.

    abstract:PURPOSE:To accelerate the acquisition of J-resolved proton magnetic resonance spectroscopic imaging (1 H-MRSI) data for high-resolution mapping of brain metabolites and neurotransmitters. METHODS:The proposed method used a subspace model to represent multidimensional spatiospectral functions, which significantly reduc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28413

    authors: Tang L,Zhao Y,Li Y,Guo R,Clifford B,El Fakhri G,Ma C,Liang ZP,Luo J

    更新日期:2021-01-01 00:00:00

  • Quantitative proton magnetic resonance spectroscopy of the human cervical spinal cord at 3 Tesla.

    abstract::Cervical spinal cord spectroscopy has the potential to add metabolic information to spinal cord MRI and improve the clinical evaluation and research investigation of spinal cord diseases, such as multiple sclerosis (MS) and intraspinal tumors. However, in vivo proton MR spectroscopy ((1)H-MRS) of the spinal cord is di...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21113

    authors: Marliani AF,Clementi V,Albini-Riccioli L,Agati R,Leonardi M

    更新日期:2007-01-01 00:00:00

  • High resolution hyperpolarized 13 C MRSI using SPICE at 9.4T.

    abstract:PURPOSE:To test the feasibility of using the SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) technique, which uses the partial separability of spectroscopic data, for high resolution hyperpolarized (HP) 13 C spectroscopic imaging. METHODS:Numerical simulations were performed to investigate the i...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27061

    authors: Lee H,Song JE,Shin J,Joe E,Joo CG,Choi YS,Song HT,Kim DH

    更新日期:2018-08-01 00:00:00

  • Direct saturation-corrected chemical exchange saturation transfer MRI of glioma: Simplified decoupling of amide proton transfer and nuclear overhauser effect contrasts.

    abstract:PURPOSE:Chemical exchange saturation transfer (CEST) MRI has shown promise in tissue characterization in diseases like stroke and tumor. However, in vivo CEST imaging such as amide proton transfer (APT) MRI is challenging because of concomitant factors such as direct water saturation, macromolecular magnetization trans...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26959

    authors: Yuwen Zhou I,Wang E,Cheung JS,Lu D,Ji Y,Zhang X,Fulci G,Sun PZ

    更新日期:2017-12-01 00:00:00

  • Noise removal in magnetic resonance diffusion tensor imaging.

    abstract::Although promising for visualizing the structure of ordered tissues, MR diffusion tensor imaging (DTI) has been hampered by long acquisition time and low spatial resolution associated with its inherently low signal-to-noise ratio (SNR). Moreover, the uncertainty in the DTI measurements has a direct impact on the accur...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20582

    authors: Chen B,Hsu EW

    更新日期:2005-08-01 00:00:00

  • Real-time observation of transient focal ischemia and hyperemia in cat brain.

    abstract::Gradient-recalled echo-planar (T2*-weighted) imaging was used to noninvasively monitor regional blood oxygenation state changes in real time during transient episodes of focal ischemia in cat brain. Varying ischemic intervals (12 s to 30 min) were caused by middle cerebral artery occlusion. A rapid signal drop was not...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910270220

    authors: De Crespigny AJ,Wendland MF,Derugin N,Kozniewska E,Moseley ME

    更新日期:1992-10-01 00:00:00

  • Neurobehavioral effects among subjects exposed to high static and gradient magnetic fields from a 1.5 Tesla magnetic resonance imaging system--a case-crossover pilot study.

    abstract::The interactive use of magnetic resonance imaging (MRI) techniques is increasing in operating theaters. A study was performed on 17 male company volunteers to assess the neurobehavioral effects of exposure to magnetic fields from a 1.5 Tesla MRI system. The subjects' neurobehavioral performances on a neurobehavioral t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10604

    authors: de Vocht F,van-Wendel-de-Joode B,Engels H,Kromhout H

    更新日期:2003-10-01 00:00:00

  • A semiautomatic method for rapid segmentation of velocity-encoded myocardial magnetic resonance imaging data.

    abstract:PURPOSE:To develop a semiautomatic method for rapid segmentation of myocardial tissue phase mapping (TPM) data. METHODS:Manual segmentation of the myocardium was performed at end-diastole and end-systole. The points in both user-defined masks were then automatically tracked over the entire cardiac cycle using temporal...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26486

    authors: Espe EKS,Skårdal K,Aronsen JM,Zhang L,Sjaastad I

    更新日期:2017-09-01 00:00:00

  • fMRI of auditory stimulation with intermolecular double-quantum coherences (iDQCs) at 1.5T.

    abstract::An intermolecular double-quantum coherence (iDQC) imaging technique was used to study auditory activation in the human brain at 1.5T with a dual temporal lobe surface phased array coil and a quadrature head coil. Preliminary results demonstrate that it is feasible to obtain auditory activation maps using iDQC imaging ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200103)45:3<356::aid-mrm1046>3.0

    authors: Zhong J,Kwok E,Chen Z

    更新日期:2001-03-01 00:00:00

  • Human whole blood T2 relaxometry at 3 Tesla.

    abstract::A precise understanding of human blood spin-spin relaxation is of major importance for numerous applications, particularly functional magnetic resonance imaging (fMRI), which is increasingly performed at 3 Tesla. It is well known that T2 measured from partially deoxygenated blood depends on the Carr-Purcell Meiboom-Gi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21858

    authors: Chen JJ,Pike GB

    更新日期:2009-02-01 00:00:00

  • Myocardial effective transverse relaxation time T2* Correlates with left ventricular wall thickness: A 7.0 T MRI study.

    abstract:PURPOSE:Myocardial effective relaxation time T2* is commonly regarded as a surrogate for myocardial tissue oxygenation. However, it is legitimate to assume that there are multiple factors that influence T2*. To this end, this study investigates the relationship between T2* and cardiac macromorphology given by left vent...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26312

    authors: Huelnhagen T,Hezel F,Serradas Duarte T,Pohlmann A,Oezerdem C,Flemming B,Seeliger E,Prothmann M,Schulz-Menger J,Niendorf T

    更新日期:2017-06-01 00:00:00

  • Measurement of perfusion and permeability from dynamic contrast-enhanced MRI in normal and pathological vertebral bone marrow.

    abstract::Dynamic contrast-enhanced MRI data in vertebral bone marrow (vBM) are currently analyzed with descriptive indices. The purpose of this study was to develop and evaluate a quantitative approach, considering the tissue composition of vBM. Therefore, a measurement of the water fraction, f(wat), and the precontrast relaxa...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22415

    authors: Biffar A,Sourbron S,Schmidt G,Ingrisch M,Dietrich O,Reiser MF,Baur-Melnyk A

    更新日期:2010-07-01 00:00:00

  • Spatially resolved assessment of serotonin-induced bronchoconstrictive responses in the rat lung using 3He ventilation MRI under spontaneous breathing conditions.

    abstract::The effect on lung ventilation of bronchoconstriction induced by serotonin (intravenous injection of 50 microg/kg of serotonin) was imaged using a hyperpolarized (3)He MR ventilation protocol in spontaneously breathing rats. Lung function maps assessing airflow obstruction, a key feature in clinical pneumology, were d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22391

    authors: Mosbah K,Stupar V,Berthezène Y,Beckmann N,Crémillieux Y

    更新日期:2010-06-01 00:00:00

  • Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice.

    abstract::In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episode...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320603

    authors: Preece NE,Amor S,Baker D,Gadian DG,O'Neill JK,Urenjak J

    更新日期:1994-12-01 00:00:00

  • Numerical simulations of carotid MRI quantify the accuracy in measuring atherosclerotic plaque components in vivo.

    abstract:PURPOSE:Atherosclerotic carotid plaques can be quantified in vivo by MRI. However, the accuracy in segmentation and quantification of components such as the thin fibrous cap (FC) and lipid-rich necrotic core (LRNC) remains unknown due to the lack of a submillimeter scale ground truth. METHODS:A novel approach was take...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24905

    authors: Nieuwstadt HA,Geraedts TR,Truijman MT,Kooi ME,van der Lugt A,van der Steen AF,Wentzel JJ,Breeuwer M,Gijsen FJ

    更新日期:2014-07-01 00:00:00

  • Spin-locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons.

    abstract::Chemical exchange saturation transfer (CEST) and spin-locking (SL) experiments were both able to probe the exchange process between protons of nonequivalent chemical environments. To compare the characteristics of the CEST and SL approaches in the study of chemical exchange effects, we performed CEST and SL experiment...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22721

    authors: Jin T,Autio J,Obata T,Kim SG

    更新日期:2011-05-01 00:00:00

  • Dynamic per slice shimming for simultaneous brain and spinal cord fMRI.

    abstract:PURPOSE:Simultaneous brain and spinal cord functional MRI is emerging as a new tool to study the central nervous system but is challenging. Poor B0 homogeneity and small size of the spinal cord are principal obstacles to this nascent technology. Here we extend a dynamic shimming approach, first posed by Finsterbusch, b...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27388

    authors: Islam H,Law CSW,Weber KA,Mackey SC,Glover GH

    更新日期:2019-02-01 00:00:00

  • In vivo detection of a pH-sensitive nitroxide in the rat stomach by low-field ESR-based techniques.

    abstract::A study was made of the in vivo detectability of a pH-sensitive, imidazolidine spin probe, and the efficacy of low-frequency electron spin resonance (ESR)-based techniques for pH measurement in vitro and in vivo in rats. The techniques used were longitudinally-detected ESR (LODESR) and field-cycled dynamic nuclear pol...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10392

    authors: Foster MA,Grigor'ev IA,Lurie DJ,Khramtsov VV,McCallum S,Panagiotelis I,Hutchison JM,Koptioug A,Nicholson I

    更新日期:2003-03-01 00:00:00

  • Deuterium magnetic resonance imaging of rabbit eye in vivo.

    abstract::We used deuterium magnetic resonance imaging (2H MRI) to visualize water movement in the rabbit eye. Dynamic 2H MRI was obtained every 3.5 min at 2 tesla by FLASH pulse sequence (TR, 300 ms; TE, 10 ms; alpha = 90 degrees) with a slice thickness of 10 mm using a surface coil (4 cm in diameter). After topical administra...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910330417

    authors: Obata T,Ikehira H,Koga M,Yoshida K,Kimura F,Tateno Y

    更新日期:1995-04-01 00:00:00

  • Comparison of k-space sampling schemes for multidimensional MR spectroscopic imaging.

    abstract::For clinical 31P MR spectroscopic imaging (MRSI) studies, where signal averaging is necessary, some improvement of sensitivity and spatial response function may be achieved by acquiring data over a spherical k-space volume and varying the number of averages acquired in proportion to the desired spatial filter. Eight d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360321

    authors: Hugg JW,Maudsley AA,Weiner MW,Matson GB

    更新日期:1996-09-01 00:00:00

  • MR coil design for simultaneous tip tracking and curvature delineation of a catheter.

    abstract::In active catheter tracking, small RF coils are attached to the catheter for localization. For interactive catheter steering at vessel branchings, it is necessary to visualize not only a single point near the catheter tip but also the entire shape and orientation of the catheter's distal end. Therefore, a 35-mm-long t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20108

    authors: Zuehlsdorff S,Umathum R,Volz S,Hallscheidt P,Fink C,Semmler W,Bock M

    更新日期:2004-07-01 00:00:00

  • Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model.

    abstract::Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk tissues. Cerebral-blood-flow (CBF) and apparent diffusion coefficient (ADC) were measured at high and low resolution (HR = 128 x 128, LR = 64 x 64) in focal ischemia in rats during the acute phase. The data ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20299

    authors: Ren H,Shen Q,Bardutzky J,Fisher M,Duong TQ

    更新日期:2004-12-01 00:00:00

  • Four-dimensional flow MRI using spiral acquisition.

    abstract::Time-resolved three-dimensional phase-contrast MRI is an important tool for physiological as well as clinical studies of blood flow in the heart and vessels. The application of the technique is, however, limited by the long scan times required. In this work, we investigate the feasibility of using spiral readouts to r...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23297

    authors: Sigfridsson A,Petersson S,Carlhäll CJ,Ebbers T

    更新日期:2012-10-01 00:00:00

  • Dynamic imaging of perfusion in human skeletal muscle during exercise with arterial spin labeling.

    abstract::MR images acquired by using an arterial spin-labeling technique showed spatial and temporal variations of perfusion in the skeletal muscle of exercising humans. Perfusion measurements made during plantar flexion exercise in normal volunteers were consistent with those obtained by traditional techniques reported in the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199908)42:2<258::aid-mrm7>

    authors: Frank LR,Wong EC,Haseler LJ,Buxton RB

    更新日期:1999-08-01 00:00:00