Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice.

Abstract:

:In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo-inositol during acute and again during chronic relapsing EAE. The ratio of N-acetyl-aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.

journal_name

Magn Reson Med

authors

Preece NE,Amor S,Baker D,Gadian DG,O'Neill JK,Urenjak J

doi

10.1002/mrm.1910320603

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

692-7

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

32

pub_type

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