Diffusion-weighted imaging of the human optic nerve: a new approach to evaluate optic neuritis in multiple sclerosis.

Abstract:

:The apparent diffusion coefficient (ADC) in the optic nerve was measured from diffusion-weighted magnetic resonance imaging using an intravoxel incoherent motion (IVIM) sequence. The subjects were seven normal volunteers and eight patients with multiple sclerosis (MS) with a total of four optic nerves with acute neuritis and nine nerves with chronic neuritis. The mean ADC (4.18 +/- 1.13 x 10(-3) mm2/s, n = 9) in the optic nerves with chronic neuritis was significantly higher than that in normal volunteers (1.56 +/- 0.675 x 10(-3) mm2/s, n = 14) and that in the nerves with acute neuritis (0.94 +/- 0.43 x 10(-3) mm2/s n = 4) (P < 0.001). The ADC is useful in assessing MS foci in the optic nerves.

journal_name

Magn Reson Med

authors

Iwasawa T,Matoba H,Ogi A,Kurihara H,Saito K,Yoshida T,Matsubara S,Nozaki A

doi

10.1002/mrm.1910380317

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

484-91

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

38

pub_type

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