fMRI of auditory stimulation with intermolecular double-quantum coherences (iDQCs) at 1.5T.

Abstract:

:An intermolecular double-quantum coherence (iDQC) imaging technique was used to study auditory activation in the human brain at 1.5T with a dual temporal lobe surface phased array coil and a quadrature head coil. Preliminary results demonstrate that it is feasible to obtain auditory activation maps using iDQC imaging at 1.5T, both in individual subjects using the surface coil array and with multisubject averaging of data using the head coil. The most robust activation map was obtained when a spin-echo (SE) acquisition was combined with an iDQC excitation. Since SE with conventional single quantum coherence (SQC) and similar parameters showed much reduced activation in spite of its higher signal-to-noise ratio (SNR), it was determined that activation resulting from the SE-iDQC acquisition almost entirely originates from iDQCs. In addition, the fact that the robust activation was obtained using signals at an evolution time more sensitive to changes in magnetic susceptibilities also suggests the sensitivity of iDQCs to the BOLD effect upon activation. iDQCs provide a novel MRI method which is potentially more sensitive to the BOLD effect traditionally measured with SQC. Magn Reson Med 45:356-364, 2001.

journal_name

Magn Reson Med

authors

Zhong J,Kwok E,Chen Z

doi

10.1002/1522-2594(200103)45:3<356::aid-mrm1046>3.0

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

356-64

issue

3

eissn

0740-3194

issn

1522-2594

pii

10.1002/1522-2594(200103)45:3<356::AID-MRM1046>3.0

journal_volume

45

pub_type

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