Numerical simulations of carotid MRI quantify the accuracy in measuring atherosclerotic plaque components in vivo.


PURPOSE:Atherosclerotic carotid plaques can be quantified in vivo by MRI. However, the accuracy in segmentation and quantification of components such as the thin fibrous cap (FC) and lipid-rich necrotic core (LRNC) remains unknown due to the lack of a submillimeter scale ground truth. METHODS:A novel approach was taken by numerically simulating in vivo carotid MRI providing a ground truth comparison. Upon evaluation of a simulated clinical protocol, MR readers segmented simulated images of cross-sectional plaque geometries derived from histological data of 12 patients. RESULTS:MR readers showed high correlation (R) and intraclass correlation (ICC) in measuring the luminal area (R = 0.996, ICC = 0.99), vessel wall area (R = 0.96, ICC = 0.94) and LRNC area (R = 0.95, ICC = 0.94). LRNC area was underestimated (mean error, -24%). Minimum FC thickness showed a mediocre correlation and intraclass correlation (R = 0.71, ICC = 0.69). CONCLUSION:Current clinical MRI can quantify carotid plaques but shows limitations for thin FC thickness quantification. These limitations could influence the reliability of carotid MRI for assessing plaque rupture risk associated with FC thickness. Overall, MRI simulations provide a feasible methodology for assessing segmentation and quantification accuracy, as well as for improving scan protocol design.


Magn Reson Med


Nieuwstadt HA,Geraedts TR,Truijman MT,Kooi ME,van der Lugt A,van der Steen AF,Wentzel JJ,Breeuwer M,Gijsen FJ




Has Abstract


2014-07-01 00:00:00












  • New method for contrast manipulation in DNP-enhanced MRI.

    abstract::The magnetization subtraction technique (MS), which is equivalent to the inversion recovery technique in strong magnetic fields, has been implemented in dynamic nuclear polarization-enhanced magnetic resonance imaging (DNPI). The general theoretical basis of the MS method, which can be applied to DNPI or to prepolariz...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Planinsic G,Grucker D,Stepisnik J

    更新日期:1996-03-01 00:00:00

  • GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI.

    abstract:PURPOSE:To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. METHODS:The onVDMP method was applied for the detection of water signal changes upo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Xu X,Xu J,Chan KWY,Liu J,Liu H,Li Y,Chen L,Liu G,van Zijl PCM

    更新日期:2019-01-01 00:00:00

  • Triple diffusion encoding MRI predicts intra-axonal and extra-axonal diffusion tensors in white matter.

    abstract:PURPOSE:To demonstrate how triple diffusion encoding (TDE) MRI can be applied to separately estimate the intra-axonal and extra-axonal diffusion tensors in white matter (WM). METHODS:Using a TDE pulse sequence with an axially symmetric b-matrix, diffusion MRI data were acquired at 3T for 3 healthy adults with an axial...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Ramanna S,Moss HG,McKinnon ET,Yacoub E,Helpern JA,Jensen JH

    更新日期:2020-06-01 00:00:00

  • A z-gradient array for simultaneous multi-slice excitation with a single-band RF pulse.

    abstract:PURPOSE:Multi-slice radiofrequency (RF) pulses have higher specific absorption rates, more peak RF power, and longer pulse durations than single-slice RF pulses. Gradient field design techniques using a z-gradient array are investigated for exciting multiple slices with a single-band RF pulse. THEORY AND METHODS:Two d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Ertan K,Taraghinia S,Sadeghi A,Atalar E

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  • Three-dimensional magnetization-prepared time-of-flight MR angiography of the carotid and vertebral arteries.

    abstract::Three-dimensional magnetization-prepared (MP) MR angiography (MRA) was applied to the carotid and vertebral arteries by using ECG triggering, a slab selective RF inversion pulse, centric phase encoding and acquisition during diastole. Both theoretically and experimentally, the MP MRA sequence was shown to perform well...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Wilman AH,Huston J 3rd,Riederer SJ

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  • Magnetization-prepared shells trajectory with automated gradient waveform design.

    abstract:PURPOSE:To develop a fully automated trajectory and gradient waveform design for the non-Cartesian shells acquisition, and to develop a magnetization-prepared (MP) shells acquisition to achieve an efficient three-dimensional acquisition with improved gray-to-white brain matter contrast. METHODS:After reviewing the she...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Shu Y,Tao S,Trzasko JD,Huston J 3rd,Weavers PT,Bernstein MA

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  • Oxygen-sensitive contrast in blood for steady-state free precession imaging.

    abstract::Steady-state free precession (SSFP) methods have gained widespread recognition for their ability to provide fast scans at high signal-to-noise ratio. This paper demonstrates that such methods are also capable of reflecting functional information, particularly blood oxygenation state. It is well known that SSFP signals...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Dharmakumar R,Hong J,Brittain JH,Plewes DB,Wright GA

    更新日期:2005-03-01 00:00:00

  • Nonuniform and multidimensional Shinnar-Le Roux RF pulse design method.

    abstract::The Shinnar-Le Roux (SLR) radiofrequency (RF) pulse design algorithm is widely used for designing slice-selective RF pulses due to its intuitiveness, optimality, and speed. SLR is limited, however, in that it is only capable of designing one-dimensional pulses played along constant gradients. We present a nonuniform S...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Grissom WA,McKinnon GC,Vogel MW

    更新日期:2012-09-01 00:00:00

  • Volumetric navigators for real-time motion correction in diffusion tensor imaging.

    abstract::Prospective motion correction methods using an optical system, diffusion-weighted prospective acquisition correction, or a free induction decay navigator have recently been applied to correct for motion in diffusion tensor imaging. These methods have some limitations and drawbacks. This article describes a novel techn...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Alhamud A,Tisdall MD,Hess AT,Hasan KM,Meintjes EM,van der Kouwe AJ

    更新日期:2012-10-01 00:00:00

  • MR elastography for evaluating regeneration of tissue-engineered cartilage in an ectopic mouse model.

    abstract:PURPOSE:The purpose of the present study was to apply noninvasive methods for monitoring regeneration and mechanical properties of tissue-engineered cartilage in vivo at different growth stages using MR elastography (MRE). METHODS:Three types of scaffolds, including silk, collagen, and gelatin seeded by human mesenchy...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Khalilzad-Sharghi V,Han Z,Xu H,Othman SF

    更新日期:2016-03-01 00:00:00

  • Image reconstruction using a gradient impulse response model for trajectory prediction.

    abstract:PURPOSE:Gradient imperfections remain a challenge in MRI, especially for sequences relying on long imaging readouts. This work aims to explore image reconstruction based on k-space trajectories predicted by an impulse response model of the gradient system. THEORY AND METHODS:Gradient characterization was performed twi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Vannesjo SJ,Graedel NN,Kasper L,Gross S,Busch J,Haeberlin M,Barmet C,Pruessmann KP

    更新日期:2016-07-01 00:00:00

  • Perturbation of longitudinal relaxation rate in rotating frame (PLRF) analysis for quantification of chemical exchange saturation transfer signal in a transient state.

    abstract:PURPOSE:To develop a novel analytical method for quantification of chemical exchange saturation transfer (CEST) in the transient state. The proposed method aims to reduce the effects of non-chemical-exchange (non-CE) parameters on the CEST signal, emphasizing the effect of chemical exchange. METHODS:The difference in ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Wang Y,Zhang Y,Zhao X,Wu B,Gao JH

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  • Wavelet packet denoising of magnetic resonance images: importance of Rician noise at low SNR.

    abstract::Wavelet packet analysis is a mathematical transformation that can be used to post-process images, for example, to remove image noise ("denoising"). At a very low signal-to-noise ratio (SNR <5), standard magnitude magnetic resonance images have skewed Rician noise statistics that degrade denoising performance. Since th...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Wood JC,Johnson KM

    更新日期:1999-03-01 00:00:00

  • Multi-angle ratiometric approach to measure chemical exchange in amide proton transfer imaging.

    abstract::Amide proton transfer imaging, a specific form of chemical exchange saturation transfer imaging, has previously been applied to studies of acute ischemic acidosis, stroke, and cancer. However, interpreting the resulting contrast is complicated by its dependence on the exchange rate between amides and water, the amide ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Zu Z,Janve VA,Li K,Does MD,Gore JC,Gochberg DF

    更新日期:2012-09-01 00:00:00

  • A reduced field-of-view method to increase temporal resolution or reduce scan time in cine MRI.

    abstract::In some dynamic applications of MRI, only a part of the field-of-view (FOV) actually undergoes dynamic changes. A class of methods, called reduced-FOV (rFOV) methods, convert the knowledge that some part of the FOV is static or not very dynamic into an increase in temporal resolution for the dynamic part, or into a re...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Madore B,Fredrickson JO,Alley MT,Pelc NJ

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  • Design of universal parallel-transmit refocusing kT -point pulses and application to 3D T2 -weighted imaging at 7T.

    abstract:PURPOSE:T2 -weighted sequences are particularly sensitive to the radiofrequency (RF) field inhomogeneity problem at ultra-high-field because of the errors accumulated by the imperfections of the train of refocusing pulses. As parallel transmission (pTx) has proved particularly useful to counteract RF heterogeneities, u...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Gras V,Mauconduit F,Vignaud A,Amadon A,Le Bihan D,Stöcker T,Boulant N

    更新日期:2018-07-01 00:00:00

  • Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRI.

    abstract::Simulations of dynamic susceptibility contrast (DSC) MRI are frequently performed by assuming a certain shape for the input function and the microvascular response function. However, to investigate the influence of parameters that will affect the shape of the input function, a more complex model of the human vasculatu...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: van Osch MJ,Vonken EJ,Wu O,Viergever MA,van der Grond J,Bakker CJ

    更新日期:2003-09-01 00:00:00

  • Proton magnetic resonance spectroscopy of Sjögren-Larsson syndrome heterozygotes.

    abstract::A deficit of fatty alcohol:NAD+ oxidoreductase complex (FAO) activity has been detected in patients with the Sjögren-Larsson syndrome (SLS). A moderate decrease in FAO activity has also been reported in heterozygote SLS subjects. Abnormal peaks were detected with proton magnetic resonance spectroscopy (1H-MRS) in homo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Kaminaga T,Mano T,Ono J,Kusuoka H,Nakamura H,Nishimura T

    更新日期:2001-06-01 00:00:00

  • Inverse reconstruction method for segmented multishot diffusion-weighted MRI with multiple coils.

    abstract::Each k-space segment in multishot diffusion-weighted MRI is affected by a different spatially varying phase which is caused by unavoidable motions and amplified by the diffusion-encoding gradients. A proper image reconstruction therefore requires phase maps for each segment. Such maps are commonly derived from two-dim...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Uecker M,Karaus A,Frahm J

    更新日期:2009-11-01 00:00:00

  • A hybrid method for more efficient channel-by-channel reconstruction with many channels.

    abstract::In MRI, imaging using receiving coil arrays with a large number of elements is an area of growing interest. With increasing channel numbers for parallel acquisition, longer reconstruction times have become a significant concern. Channel reduction techniques have been proposed to reduce the processing time of channel-b...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Huang F,Lin W,Duensing GR,Reykowski A

    更新日期:2012-03-01 00:00:00

  • Uniform spinning sampling gradient electron paramagnetic resonance imaging.

    abstract:PURPOSE:To improve the quality and speed of electron paramagnetic resonance imaging (EPRI) acquisition by combining a uniform sampling distribution with spinning gradient acquisition. THEORY AND METHODS:A uniform sampling distribution was derived for spinning gradient EPRI acquisition (uniform spinning sampling, USS) ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Johnson DH,Ahmad R,Liu Y,Chen Z,Samouilov A,Zweier JL

    更新日期:2014-02-01 00:00:00

  • Tracer kinetic modeling in myocardial perfusion quantification using MRI.

    abstract:PURPOSE:To investigate and compare several quantification methods of myocardial perfusion measurements, paying special attention to the relation between the techniques and the required measurement duration. METHODS:Seven patients underwent contrast-enhanced rest and stress cardiac perfusion measurements at 3T. Three s...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,随机对照试验


    authors: Schwab F,Ingrisch M,Marcus R,Bamberg F,Hildebrandt K,Adrion C,Gliemi C,Nikolaou K,Reiser M,Theisen D

    更新日期:2015-03-01 00:00:00

  • Cerebrospinal fluid pulse wave velocity measurements: In vitro and in vivo evaluation of a novel multiband cine phase-contrast MRI sequence.

    abstract:PURPOSE:Intracranial and intraspinal compliance are parameters of interest in the diagnosis and prediction of treatment outcome in patients with normal pressure hydrocephalus and other forms of communicating hydrocephalus. A noninvasive method to estimate the spinal cerebrospinal fluid (CSF) pulse wave velocity (PWV) a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Sonnabend K,Brinker G,Maintz D,Bunck AC,Weiss K

    更新日期:2021-01-01 00:00:00

  • Separation and quantification of lactate and lipid at 1.3 ppm by diffusion-weighted magnetic resonance spectroscopy.

    abstract:PURPOSE:To separate the spectrally overlapped lactate and lipid signals at 1.3 ppm using diffusion-weighted magnetic resonance spectroscopy (DW-MRS) based on their large diffusivity difference. METHODS:DW-MRS was applied to the gel phantoms containing lactate and lipid droplets, and to the rat brain tumors. Lactate an...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Wang AM,Leung GK,Kiang KM,Chan D,Cao P,Wu EX

    更新日期:2017-02-01 00:00:00

  • Diffusion-weighted imaging of the human optic nerve: a new approach to evaluate optic neuritis in multiple sclerosis.

    abstract::The apparent diffusion coefficient (ADC) in the optic nerve was measured from diffusion-weighted magnetic resonance imaging using an intravoxel incoherent motion (IVIM) sequence. The subjects were seven normal volunteers and eight patients with multiple sclerosis (MS) with a total of four optic nerves with acute neuri...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Iwasawa T,Matoba H,Ogi A,Kurihara H,Saito K,Yoshida T,Matsubara S,Nozaki A

    更新日期:1997-09-01 00:00:00

  • Performance evaluation of whole-body NMR scanner antenna systems.

    abstract::Whole-body NMR imaging antennas (probes) are strongly affected by the inevitable magnetic and controllable dielectric losses. Using a convenient parallelepiped model, the magnetic losses are evaluated. By introducing the "ideal power gain," the best possible antenna performance is delimited as a function of the freque...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Sergiadis G

    更新日期:1985-08-01 00:00:00

  • Theoretical analysis of the effect of imperfect slice profiles on tagging schemes for pulsed arterial spin labeling MRI.

    abstract::Pulsed arterial spin labeling (ASL) techniques provide a noninvasive method of obtaining qualitative and quantitative perfusion images with MRI. ASL techniques employ inversion recovery and/or saturation recovery to induce perfusion weighting, and thus the performance of these techniques is dependent on the slice prof...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Keilholz-George SD,Knight-Scott J,Berr SS

    更新日期:2001-07-01 00:00:00

  • Sensitivity profiles from an array of coils for encoding and reconstruction in parallel (SPACE RIP).

    abstract::A new parallel imaging technique was implemented which can result in reduced image acquisition times in MRI. MR data is acquired in parallel using an array of receiver coils and then reconstructed simultaneously with multiple processors. The method requires the initial estimation of the 2D sensitivity profile of each ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Kyriakos WE,Panych LP,Kacher DF,Westin CF,Bao SM,Mulkern RV,Jolesz FA

    更新日期:2000-08-01 00:00:00

  • Automatic in-line quantitative myocardial perfusion mapping: Processing algorithm and implementation.

    abstract:PURPOSE:Quantitative myocardial perfusion mapping has advantages over qualitative assessment, including the ability to detect global flow reduction. However, it is not clinically available and remains a research tool. Building upon the previously described imaging sequence, this study presents algorithm and implementat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Xue H,Brown LAE,Nielles-Vallespin S,Plein S,Kellman P

    更新日期:2020-02-01 00:00:00

  • MR imaging with hyperpolarized 3He gas.

    abstract::Magnetic resonance images of the lungs of a guinea pig have been produced using hyperpolarized helium as the source of the MR signal. The resulting images are not yet sufficiently optimized to reveal fine structural detail within the lung, but the spectacular signal from this normally signal-deficient organ system off...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Middleton H,Black RD,Saam B,Cates GD,Cofer GP,Guenther R,Happer W,Hedlund LW,Johnson GA,Juvan K

    更新日期:1995-02-01 00:00:00