Numerical simulations of carotid MRI quantify the accuracy in measuring atherosclerotic plaque components in vivo.

Abstract:

PURPOSE:Atherosclerotic carotid plaques can be quantified in vivo by MRI. However, the accuracy in segmentation and quantification of components such as the thin fibrous cap (FC) and lipid-rich necrotic core (LRNC) remains unknown due to the lack of a submillimeter scale ground truth. METHODS:A novel approach was taken by numerically simulating in vivo carotid MRI providing a ground truth comparison. Upon evaluation of a simulated clinical protocol, MR readers segmented simulated images of cross-sectional plaque geometries derived from histological data of 12 patients. RESULTS:MR readers showed high correlation (R) and intraclass correlation (ICC) in measuring the luminal area (R = 0.996, ICC = 0.99), vessel wall area (R = 0.96, ICC = 0.94) and LRNC area (R = 0.95, ICC = 0.94). LRNC area was underestimated (mean error, -24%). Minimum FC thickness showed a mediocre correlation and intraclass correlation (R = 0.71, ICC = 0.69). CONCLUSION:Current clinical MRI can quantify carotid plaques but shows limitations for thin FC thickness quantification. These limitations could influence the reliability of carotid MRI for assessing plaque rupture risk associated with FC thickness. Overall, MRI simulations provide a feasible methodology for assessing segmentation and quantification accuracy, as well as for improving scan protocol design.

journal_name

Magn Reson Med

authors

Nieuwstadt HA,Geraedts TR,Truijman MT,Kooi ME,van der Lugt A,van der Steen AF,Wentzel JJ,Breeuwer M,Gijsen FJ

doi

10.1002/mrm.24905

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

188-201

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

72

pub_type

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