Abstract:
:Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl to the exposed rat cortex. MEMRI signal increase in the ipsilateral cortex relative to the contralateral control region was 60 +/- 30% following two KCl applications. MEMRI signal increase for a single (40%) versus double (80%) KCl application suggests an integration effect over successive CSD episodes. CSD-induced MEMRI enhancement involved cortical layers containing dense regions of apical dendrites, supporting the contention that these neuronal structures are necessary for propagation of CSDs. Subcortical enhancement was present in hippocampal and thalamic regions, most likely a result of neuronal connections with cortical layers 4 and 5. These results are consistent with previous studies of CSD using diffusion-weighted MRI and T(2) (*)-weighted MRI and should be useful for investigating CSD itself and its role in other neurologic disorders.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Henning EC,Meng X,Fisher M,Sotak CHdoi
10.1002/mrm.20438subject
Has Abstractpub_date
2005-04-01 00:00:00pages
851-7issue
4eissn
0740-3194issn
1522-2594journal_volume
53pub_type
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journal_title:Magnetic resonance in medicine
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