Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging.

Abstract:

:Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl to the exposed rat cortex. MEMRI signal increase in the ipsilateral cortex relative to the contralateral control region was 60 +/- 30% following two KCl applications. MEMRI signal increase for a single (40%) versus double (80%) KCl application suggests an integration effect over successive CSD episodes. CSD-induced MEMRI enhancement involved cortical layers containing dense regions of apical dendrites, supporting the contention that these neuronal structures are necessary for propagation of CSDs. Subcortical enhancement was present in hippocampal and thalamic regions, most likely a result of neuronal connections with cortical layers 4 and 5. These results are consistent with previous studies of CSD using diffusion-weighted MRI and T(2) (*)-weighted MRI and should be useful for investigating CSD itself and its role in other neurologic disorders.

journal_name

Magn Reson Med

authors

Henning EC,Meng X,Fisher M,Sotak CH

doi

10.1002/mrm.20438

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

851-7

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

53

pub_type

杂志文章
  • The sensitivity of low flip angle RARE imaging.

    abstract::It is demonstrated that the stability of the Carr-Purcell-Meiboom-Gill (CPMG) sequence reflects the existence of a steady state solution to the Bloch equations in the absence of T2 and T1 decay. The steady state theory is then used to evaluate the performance of low flip angle RARE imaging sequences with both constant...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910370206

    authors: Alsop DC

    更新日期:1997-02-01 00:00:00

  • Validation of a new T2* algorithm and its uncertainty value for cardiac and liver iron load determination from MRI magnitude images.

    abstract:PURPOSE:To validate an automatic algorithm for offline T2* measurements, providing robust, vendor-independent T2*, and uncertainty estimates for iron load quantification in the heart and liver using clinically available imaging sequences. METHODS:A T2* region of interest (ROI)-based algorithm was developed for robustn...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25767

    authors: Bidhult S,Xanthis CG,Liljekvist LL,Greil G,Nagel E,Aletras AH,Heiberg E,Hedström E

    更新日期:2016-04-01 00:00:00

  • Investigation of human cervical and upper thoracic spinal cord motion: implications for imaging spinal cord structure and function.

    abstract::Spinal cord (SC) motion is thought to be the dominant source of error in current diffusion and spinal functional MRI (fMRI) methods. However, until now, such motion has not been well characterized in three dimensions. While previous studies have predominantly examined motion in the superior/inferior (S/I) direction, t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21260

    authors: Figley CR,Stroman PW

    更新日期:2007-07-01 00:00:00

  • Pulmonary perfusion: qualitative assessment with dynamic contrast-enhanced MRI using ultra-short TE and inversion recovery turbo FLASH.

    abstract::The accurate assessment of pulmonary perfusion is especially important in the evaluation of patients with suspected pulmonary embolism, a common and potentially lethal disorder that can be treated by aggressive anticoagulation. In this study, we demonstrate for the first time the use of MR to image pulmonary perfusion...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360402

    authors: Hatabu H,Gaa J,Kim D,Li W,Prasad PV,Edelman RR

    更新日期:1996-10-01 00:00:00

  • A 32-channel lattice transmission line array for parallel transmit and receive MRI at 7 tesla.

    abstract::Transmit and receive RF coil arrays have proven to be particularly beneficial for ultra-high-field MR. Transmit coil arrays enable such techniques as B(1) (+) shimming to substantially improve transmit B(1) homogeneity compared to conventional volume coil designs, and receive coil arrays offer enhanced parallel imagin...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22413

    authors: Adriany G,Auerbach EJ,Snyder CJ,Gözübüyük A,Moeller S,Ritter J,Van de Moortele PF,Vaughan T,Uğurbil K

    更新日期:2010-06-01 00:00:00

  • Echo-planar imaging with prospective slice-by-slice motion correction using active markers.

    abstract::Head motion is a fundamental problem in functional magnetic resonance imaging and is often a limiting factor in its clinical implementation. This work presents a rigid-body motion correction strategy for echo-planar imaging sequences that uses micro radiofrequency coil "active markers" for real-time, slice-by-slice pr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22780

    authors: Ooi MB,Krueger S,Muraskin J,Thomas WJ,Brown TR

    更新日期:2011-07-01 00:00:00

  • Detection of neural activity in functional MRI using canonical correlation analysis.

    abstract::A novel method for detecting neural activity in functional magnetic resonance imaging (fMRI) data is introduced. It is based on canonical correlation analysis (CCA), which is a multivariate extension of the univariate correlation analysis widely used in fMRI. To detect homogeneous regions of activity, the method combi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200102)45:2<323::aid-mrm1041>3.0

    authors: Friman O,Cedefamn J,Lundberg P,Borga M,Knutsson H

    更新日期:2001-02-01 00:00:00

  • Measurement of perfusion and permeability from dynamic contrast-enhanced MRI in normal and pathological vertebral bone marrow.

    abstract::Dynamic contrast-enhanced MRI data in vertebral bone marrow (vBM) are currently analyzed with descriptive indices. The purpose of this study was to develop and evaluate a quantitative approach, considering the tissue composition of vBM. Therefore, a measurement of the water fraction, f(wat), and the precontrast relaxa...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22415

    authors: Biffar A,Sourbron S,Schmidt G,Ingrisch M,Dietrich O,Reiser MF,Baur-Melnyk A

    更新日期:2010-07-01 00:00:00

  • Automatic vessel removal in gliomas from dynamic susceptibility contrast imaging.

    abstract::The presence of macroscopic vessels within the tumor region is a potential confounding factor in MR-based dynamic susceptibility contrast (DSC)-enhanced glioma grading. In order to distinguish between such vessels and the elevated cerebral blood volume (CBV) of brain tumors, we propose a vessel segmentation technique ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21944

    authors: Emblem KE,Due-Tonnessen P,Hald JK,Bjornerud A

    更新日期:2009-05-01 00:00:00

  • CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena.

    abstract::Chemical exchange saturation transfer (CEST), arterial spin labeling (ASL), and magnetization transfer contrast (MTC) methods generate different contrasts for MRI. However, they share many similarities in terms of pulse sequences and mechanistic principles. They all use RF pulse preparation schemes to label the longit...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,评审

    doi:10.1002/mrm.27341

    authors: Knutsson L,Xu J,Ahlgren A,van Zijl PCM

    更新日期:2018-10-01 00:00:00

  • Sensitivity enhancement and reduction of Gibbs artifact in T2-weighted imaging using variable tip angle excitation.

    abstract::Introduction of a Gaussian weighting function into the phase encoding of the spin-echo imaging method via variable tip angle excitation, with concomitant optimization of the recycle delay, is shown to increase the sensitivity of T2-weighted imaging by up to 40%. In addition, the Gibbs artifact associated with sharp bo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910210216

    authors: Webb AG,Clarkson RB

    更新日期:1991-10-01 00:00:00

  • Constrained estimation of the arterial input function for myocardial perfusion cardiovascular magnetic resonance.

    abstract::Accurate quantification of myocardial perfusion remains challenging due to saturation of the arterial input function at high contrast concentrations. A method for estimating the arterial input function directly from tissue curves in the myocardium that avoids these difficulties is presented. In this constrained altern...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22809

    authors: Fluckiger JU,Schabel MC,DiBella EV

    更新日期:2011-08-01 00:00:00

  • A molecular theory of relaxation and magnetization transfer: application to cross-linked BSA, a model for tissue.

    abstract::Homogeneous soft tissue, as regards its magnetic relaxation properties, is well-modeled by solutions of cross-linked protein (see Koenig and Brown, Prog. NMR Spectr. 22, 487 (1991)). Interactions at the solute-solvent interface alter the hydrodynamics of solvent water, and also couple the solute and solvent proton Zee...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910300606

    authors: Koenig SH,Brown RD 3rd

    更新日期:1993-12-01 00:00:00

  • A z-gradient array for simultaneous multi-slice excitation with a single-band RF pulse.

    abstract:PURPOSE:Multi-slice radiofrequency (RF) pulses have higher specific absorption rates, more peak RF power, and longer pulse durations than single-slice RF pulses. Gradient field design techniques using a z-gradient array are investigated for exciting multiple slices with a single-band RF pulse. THEORY AND METHODS:Two d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27031

    authors: Ertan K,Taraghinia S,Sadeghi A,Atalar E

    更新日期:2018-07-01 00:00:00

  • Regional comparison of tumor vascularity and permeability parameters measured by albumin-Gd-DTPA and Gd-DTPA.

    abstract::Sequential albumin-Gd-DTPA and Gd-DTPA dynamic enhancement studies were performed in an animal tumor model for the comparison of regional vascularity and permeability parameters measured by these two different sizes of contrast agents. The early albumin-Gd-DTPA enhancement arises from the vascular compartment, and the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910340318

    authors: Su MY,Najafi AA,Nalcioglu O

    更新日期:1995-09-01 00:00:00

  • Four-dimensional flow MRI using spiral acquisition.

    abstract::Time-resolved three-dimensional phase-contrast MRI is an important tool for physiological as well as clinical studies of blood flow in the heart and vessels. The application of the technique is, however, limited by the long scan times required. In this work, we investigate the feasibility of using spiral readouts to r...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23297

    authors: Sigfridsson A,Petersson S,Carlhäll CJ,Ebbers T

    更新日期:2012-10-01 00:00:00

  • Development and optimization of hardware for delta relaxation enhanced MRI.

    abstract:PURPOSE:Delta relaxation enhanced magnetic resonance (dreMR) imaging requires an auxiliary B0 electromagnet capable of shifting the main magnetic field within a clinical 1.5 Tesla (T) MR system. In this work, the main causes of interaction between an actively shielded, insertable resistive B0 electromagnet and a 1.5T s...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25014

    authors: Harris CT,Handler WB,Araya Y,Martínez-Santiesteban F,Alford JK,Dalrymple B,Van Sas F,Chronik BA,Scholl TJ

    更新日期:2014-10-01 00:00:00

  • Three-dimensional diffusion tensor microimaging for anatomical characterization of the mouse brain.

    abstract::Diffusion tensor imaging is gaining increasing importance for anatomical imaging of the developing mouse brain. However, the application of diffusion tensor imaging to mouse brain imaging at microscopic levels is hindered by the limitation on achievable spatial resolution. In this study, fast diffusion tensor microima...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22426

    authors: Aggarwal M,Mori S,Shimogori T,Blackshaw S,Zhang J

    更新日期:2010-07-01 00:00:00

  • Three-dimensional MRI with an undersampled spherical shells trajectory.

    abstract::The shells trajectory is a 3D data acquisition method with improved efficiency compared to Cartesian sampling. It is a true center-out trajectory that does not repeatedly resample the center of k-space, and also offers advantages for motion correction. This work demonstrates that k-space undersampling can be combined ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20977

    authors: Shu Y,Riederer SJ,Bernstein MA

    更新日期:2006-09-01 00:00:00

  • A 7Li NMR study of visibility, spin relaxation, and transport in normal human erythrocytes.

    abstract::The behavior of the lithium (Li) ion in normal human erythrocytes has been studied by 7Li NMR. The uptake of Li into the cells was followed as a function of solution conditions, temperature, hematocrit, and blood age using dysprosium tripolyphosphate shift reagent. Under our conditions the uptake of Li increases with ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910200207

    authors: Gullapalli RP,Hawk RM,Komoroski RA

    更新日期:1991-08-01 00:00:00

  • x-f Choice: reconstruction of undersampled dynamic MRI by data-driven alias rejection applied to contrast-enhanced angiography.

    abstract::A technique for reconstructing dynamic undersampled MRI data, termed "x-f choice," was developed and applied to dynamic contrast-enhanced MR angiography (DCE-MRA). Regular undersampling in k-t space (a hybrid of k-space and time) creates aliasing in the conjugate x-f space that must be resolved. When regions in the ob...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21008

    authors: Malik SJ,Schmitz S,O'Regan D,Larkman DJ,Hajnal JV

    更新日期:2006-10-01 00:00:00

  • Diffusion/perfusion MR imaging of acute cerebral ischemia.

    abstract::In vivo echo-planar MR imaging was used to measure apparent diffusion coefficients (ADC) of cerebral tissues in a comprehensive noninvasive evaluation of early ischemic brain damage induced by occlusion of the middle cerebral artery (MCA) in a cat model of acute regional stroke. Within 10 min after arterial occlusion,...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910190220

    authors: Kucharczyk J,Mintorovitch J,Asgari HS,Moseley M

    更新日期:1991-06-01 00:00:00

  • Correction of chemical-shift artifacts in 19F imaging of PFOB: a robust signed magnitude method.

    abstract::This paper describes a method for correcting the chemical-shift artifacts in 19F NMR imaging of perfluoroctylbromide emulsion (PFOB) by utilizing the two spectral peaks of PFOB which have a long T2 value in conjunction with the Dixon method. Corrected images are obtained from the magnitude of the measured images using...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910230206

    authors: Lee HK,Nalcioglu O,Buxton RB

    更新日期:1992-02-01 00:00:00

  • Diffusion imaging of the spinal cord in vivo: estimation of the principal diffusivities and application to multiple sclerosis.

    abstract::Magnetic resonance (MR) diffusion imaging is a useful technique with which to increase our understanding of pathologic damage to the central nervous system. To fully quantitate diffusion and anisotropy in the spinal cord, as in other tissues, it is necessary to determine the diffusion tensor. If spinal cord diffusion ...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1522-2594(200001)43:1<133::aid-mrm16

    authors: Clark CA,Werring DJ,Miller DH

    更新日期:2000-01-01 00:00:00

  • Variable echo time imaging: signal characteristics of 1-M gadobutrol contrast agent at 1.5 and 3T.

    abstract::Gadobutrol (Gd-Bt; Gadovist(R), Schering AG) is a 1-M Gadolinium (Gd)-based contrast agent. Its higher Gd concentration allows for reduction of injection volumes in first pass contrast-enhanced MR angiography (CE-MRA) and should increase bolus sharpness and image quality. However, ambivalent results were reported. In ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21345

    authors: Stalder AF,Elverfeldt DV,Paul D,Hennig J,Markl M

    更新日期:2008-01-01 00:00:00

  • Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam.

    abstract::The detection of free radical reactions in a gelatin sample irradiated by a heavy-ion beam was tested using electron paramagnetic resonance (EPR) spectroscopic and MRI methods. Geometry and the amount of free radical generation in a sample are described. A reaction mixture containing glutathione and a nitroxyl radical...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21958

    authors: Matsumoto K,Nagata K,Yamamoto H,Endo K,Anzai K,Aoki I

    更新日期:2009-05-01 00:00:00

  • Evaluation of fluorine-19 magnetic resonance imaging of the lungs using octafluorocyclobutane in a rat model.

    abstract:PURPOSE:To test octafluorocyclobutane (OFCB) as an inhalation contrast agent for fluorine-19 MRI of the lung, and to compare the image quality of OFCB scans with perfluoropropane (PFP) scans THEORY AND METHODS: After normalizing for the number of signal averages, a theoretical comparison between the OFCB signal-to-nois...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28473

    authors: Shepelytskyi Y,Li T,Grynko V,Newman C,Hane FT,Albert MS

    更新日期:2021-02-01 00:00:00

  • Accurate quantification of in vivo 31P NMR signals using the variable projection method and prior knowledge.

    abstract::Free induction decay signals are analyzed by fitting a model function directly in the time domain. No starting values are needed for linear model parameters, and omission of corrupted data points poses no problems. A significant gain of accuracy is achieved by imposing prior knowledge about the model parameters. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910060111

    authors: van der Veen JW,de Beer R,Luyten PR,van Ormondt D

    更新日期:1988-01-01 00:00:00

  • Fast three-dimensional inner volume excitations using parallel transmission and optimized k-space trajectories.

    abstract:PURPOSE:To design short parallel transmission (pTx) pulses for excitation of arbitrary three-dimensional (3D) magnetization patterns. METHODS:We propose a joint optimization of the pTx radiofrequency (RF) and gradient waveforms for excitation of arbitrary 3D magnetization patterns. Our optimization of the gradient wav...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26021

    authors: Davids M,Schad LR,Wald LL,Guérin B

    更新日期:2016-10-01 00:00:00

  • Localized proton MR spectroscopy of the human kidney in vivo by means of short echo time STEAM sequences.

    abstract::In order to obtain proton magnetic resonance spectra from the normal human kidney in vivo, we employed a STEAM sequence with delay times TE = 10 ms and TM = 30 ms. Signals are attenuated during STEAM sequences by J-coupling effects and by macroscopic movement of the sample. The combination of short echo times and resp...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310503

    authors: Dixon RM,Frahm J

    更新日期:1994-05-01 00:00:00