Diffusion imaging of the spinal cord in vivo: estimation of the principal diffusivities and application to multiple sclerosis.

Abstract:

:Magnetic resonance (MR) diffusion imaging is a useful technique with which to increase our understanding of pathologic damage to the central nervous system. To fully quantitate diffusion and anisotropy in the spinal cord, as in other tissues, it is necessary to determine the diffusion tensor. If spinal cord diffusion is assumed to be cylindrically symmetric and the orientation of the cord in the gradient frame is known, then it is shown that full quantification is possible from only three images, two of which are diffusion-weighted. Mean diffusivity and volume ratio were determined in the normal cord of four healthy volunteers and in seven cord lesions of three patients with clinically definite multiple sclerosis (MS) who had locomotor disability suggesting the presence of spinal pathology. MS cord lesions exhibited increased mean diffusivity reflecting structural damage to the cord white matter. Quantification of diffusion and anisotropy using spinal cord diffusion imaging provides new structural information in relation to spinal cord pathology in vivo.

journal_name

Magn Reson Med

authors

Clark CA,Werring DJ,Miller DH

doi

10.1002/(sici)1522-2594(200001)43:1<133::aid-mrm16

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

133-8

issue

1

eissn

0740-3194

issn

1522-2594

pii

10.1002/(SICI)1522-2594(200001)43:1<133::AID-MRM16

journal_volume

43

pub_type

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