Improved sensitivity to overlapping multiplet signals in in vivo proton spectroscopy using a multiecho volume selective (CPRESS) experiment.

Abstract:

:A method for volume selective proton spectroscopy is presented based on a multiecho sequence with short refocusing interval tcp. It is demonstrated, that by appropriate choice of tcp on the order of 4-6 ms, signals from overlapping multiplets like the glutamine and glutamate (Glu/Gln) resonances in spectra of the human brain are considerably increased compared with a conventional PRESS volume selection scheme. Thus proton spectra from J-coupled multiplet signals can be acquired with TE on the order of 20-30 ms avoiding the baseline problems arising at shorter echo times due to broad resonances. This allows to selectively acquire spectra from substances with longer T2 without the confounding effects from J-coupling occurring in conventional volume selection techniques.

journal_name

Magn Reson Med

authors

Hennig J,Thiel T,Speck O

doi

10.1002/mrm.1910370603

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

816-20

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

37

pub_type

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