Abstract:
:Gliomas are the most common primary brain tumors and the majority are highly malignant, with one of the worst prognoses for patients. Gliomas are characterized by invasive growth into normal brain tissue that makes complete surgical resection and accurate radiotherapy planning extremely difficult. We have performed independent component analysis of magnetic resonance spectroscopy imaging data from human gliomas to segment brain tissue into tumor core, tumor infiltration, and normal brain, with confirmation by diffusion tensor imaging analysis. Our data are consistent with previous studies that compared anomalies in isotropic and anisotropic diffusion images to determine regions of potential glioma infiltration. We show that coefficients of independent components can be used to create colored images for easy visual identification of regions of infiltrative tumor growth.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Wright AJ,Fellows G,Byrnes TJ,Opstad KS,McIntyre DJ,Griffiths JR,Bell BA,Clark CA,Barrick TR,Howe FAdoi
10.1002/mrm.22163subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1646-51issue
6eissn
0740-3194issn
1522-2594journal_volume
62pub_type
杂志文章abstract:PURPOSE:Conventional 31 P chemical shift imaging is time-consuming and yields only limited spatial resolution. The purpose of this study was to demonstrate feasibility of 31 P echo-planar spectroscopic imaging (EPSI) in vivo at 7T. METHODS:A 3D 31 P EPSI sequence with trapezoidal-shaped gradient pulses was implemented...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26785
更新日期:2018-03-01 00:00:00
abstract::Three-dimensional magnetization-prepared (MP) MR angiography (MRA) was applied to the carotid and vertebral arteries by using ECG triggering, a slab selective RF inversion pulse, centric phase encoding and acquisition during diastole. Both theoretically and experimentally, the MP MRA sequence was shown to perform well...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910370219
更新日期:1997-02-01 00:00:00
abstract::The concept of temporal echo multiplexing is defined and used to develop rapid biphasic spin-echo sequences for imaging the heart. Three imaging sequences, based on four-echo and two-echo multiplexing and rapid single echo (i.e., conventional spin-echo imaging), are compared. Preliminary results indicate that two-echo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910110109
更新日期:1989-07-01 00:00:00
abstract::Dynamic susceptibility contrast (DSC) MRI is now increasingly used for measuring perfusion in many different applications. The quantification of DSC data requires the measurement of the arterial input function (AIF) and the deconvolution of the tissue concentration time curve. One of the most accepted deconvolution me...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200009)44:3<466::aid-mrm18>3.0.c
更新日期:2000-09-01 00:00:00
abstract::We have noninvasively produced low-resolution, quantitative nuclear magnetic resonance images of cerebral blood flow in 2-ml voxels in eight cats. Typical signal-to-noise of 4 to 1 was obtained in cerebral voxels in 16.5-s epochs. Mean flow during normocapnia (paCO2 = 39 +/- 4 mm Hg) and hypercapnia (paCO2 = 62 +/- 4 ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910280105
更新日期:1992-11-01 00:00:00
abstract::Chemical shift-based multipoint water-fat separation methods have been applied in balanced steady-state free precession (bSSFP) sequences because of the high signal-to-noise-ratio (SNR) attainable. In this approach the echo formation is approximated to occur concurrently for both water and fat at an echo time (TE) equ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21303
更新日期:2007-08-01 00:00:00
abstract::The potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison, was studied with rat liver imaging at 7 T. Optison suspension in two different dos...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20181
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:We propose a new acquisition to minimize the per-excitation encoding duration and improve the imaging capability for short T2 * species. METHODS:In the proposed ramped hybrid encoding (RHE) technique, gradients are applied before the radiofrequency (RF) pulse as in pointwise encoding time reduction with radial...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25977
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:In contrast to conventional linear gradients, gradient coil arrays with arbitrary spatial dependency might experience strong mutual coupling. Although conventional gradient power amplifiers with feedback loop might compensate the effect of coupling, required voltages for the compensation are generally unknown a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27768
更新日期:2019-09-01 00:00:00
abstract::The use of phase correlation to detect rigid-body translational motion is reviewed and applied to individual echotrains in turbo-spin-echo data acquisition. It is shown that when the same echotrain is acquired twice, the subsampled correlation provides an array of delta-functions, from which the motion that occurred b...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21883
更新日期:2009-03-01 00:00:00
abstract::A gradient coil design algorithm capable of controlling the position of the homogeneous region of interest (ROI) with respect to the current-carrying wires is required for many advanced imaging and spectroscopy applications. A modified minimum inductance target field method that allows the placement of a set of constr...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910390214
更新日期:1998-02-01 00:00:00
abstract::Parallel imaging based on generalized autocalibrating partially parallel acquisitions is widely used in the clinical routine. To date, no detailed analysis has been presented describing the dependence of the image quality on the reconstruction and acquisition parameters such as the number of autocalibration signal (AC...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22803
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To develop a prospective baseline enhancement that compensates for intermingled background effects in Z-spectra to achieve sensitivity enhancement of peaks related to CEST and nuclear Overhauser effect. METHODS:An MRI sequence-specific compensation of background effects is achieved through variation of the pul...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27555
更新日期:2019-04-01 00:00:00
abstract::Signal-to-noise ratio (SNR) is a major challenge to sodium magnetic resonance imaging. Phased array coils have been shown significantly improving SNR in proton imaging over volume coils. This study investigates SNR advantage of a 15-channel array head coil (birdcage volume coil for transmit/receive and 15-channel arra...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24192
更新日期:2012-12-01 00:00:00
abstract::A new NMR imaging technique, aiming at a reduction of the data acquisition time, is described in detail. The method is applicable in all multidimensional imaging situations where at least one spatial coordinate is resolved. Discussed at some length are the point-spread function, the required bandwidth of the NMR spect...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910020304
更新日期:1985-06-01 00:00:00
abstract::The image intensity in magnetic resonance magnitude images in the presence of noise is shown to be governed by a Rician distribution. Low signal intensities (SNR < 2) are therefore biased due to the noise. It is shown how the underlying noise can be estimated from the images and a simple correction scheme is provided ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910340618
更新日期:1995-12-01 00:00:00
abstract::Human mesenchymal stem cells (hMSCs) were labeled with Ferucarbotran by simple incubation and cultured for up to 14 d. Iron content was determined by spectrometry and the intracellular localization of the contrast agent uptake was studied by electron and confocal microscopy. At various time points after labeling, rang...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22011
更新日期:2009-08-01 00:00:00
abstract::Images of hyperpolarized 3He were acquired during breath-hold in four healthy volunteers with the use of an optimized 3D gradient-echo sequence. The images were compared with existing 2D gradient-echo methods. The average SNR from a 13-mm-thick slice in the peripheral lung was 1.4 times greater with 3D. In the airways...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20164
更新日期:2004-09-01 00:00:00
abstract::A deficit of fatty alcohol:NAD+ oxidoreductase complex (FAO) activity has been detected in patients with the Sjögren-Larsson syndrome (SLS). A moderate decrease in FAO activity has also been reported in heterozygote SLS subjects. Abnormal peaks were detected with proton magnetic resonance spectroscopy (1H-MRS) in homo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1146
更新日期:2001-06-01 00:00:00
abstract:PURPOSE:Subendocardial dark-rim artifacts (DRAs) remain a major concern in first-pass perfusion (FPP) myocardial MRI and may lower the diagnostic accuracy for detection of ischemia. A major source of DRAs is the "Gibbs ringing" effect. We propose an optimized radial acquisition strategy aimed at eliminating ringing-ind...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24913
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:We aim to leverage the power of deep-learning with high-fidelity training data to improve the reliability and processing speed of hemodynamic mapping with MR fingerprinting (MRF) arterial spin labeling (ASL). METHODS:A total of 15 healthy subjects were studied on a 3T MRI. Each subject underwent 10 runs of a m...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28560
更新日期:2021-04-01 00:00:00
abstract:PURPOSE:Magnetization transfer ratio (MTR) histograms are used widely for the assessment of diffuse pathological changes in the brain. For broad clinical application, MTR scans should not only be fast, but confounding factors should also be minimized for high reproducibility. To this end, a 1-minute whole-brain spiral ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28618
更新日期:2020-12-08 00:00:00
abstract:PURPOSE:Proof-of-concept study of mapping renal blood flow vector field according to the inverse solution to a mass transport model of time resolved tracer-labeled MRI data. THEORY AND METHODS:To determine tissue perfusion according to the underlying physics of spatiotemporal tracer concentration variation, the mass t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28584
更新日期:2021-04-01 00:00:00
abstract::Magnetization transfer imaging (MT) and localized proton spectroscopy (1H-MRS) were utilized in the evaluation of lesions (high signal abnormalities on T2-weighted images) and normal-appearing white matter (NAWM) in multiple sclerosis (MS). Eleven patients with a clinical diagnosis of MS were independently evaluated w...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910320303
更新日期:1994-09-01 00:00:00
abstract::A method is described for multislice imaging by means of rf pulses which contain a multifrequency excitation spectrum. These pulses label each slice by an individual signal phase and allow the separation of the signals from all the slices by subsequent add/subtract procedures. The image sensitivity corresponds to the ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910060315
更新日期:1988-03-01 00:00:00
abstract:PURPOSE:The aim of the study was to investigate whether incorrectly compensated eddy currents are the source of persistent X-nuclear spectroscopy and imaging artifacts, as well as methods to correct this. METHODS:Pulse-acquire spectra were collected for 1 H and X-nuclei (23 Na or 31 P) using the minimum TR permitted o...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28607
更新日期:2020-12-04 00:00:00
abstract::Prepolarized MRI uses pulsed magnetic fields to produce MR images by polarizing the sample at one field strength (approximately 0.5 T) before imaging at a much lower field (approximately 50 mT). Contrast reflecting the T(1) of the sample at an intermediate field strength is achieved by polarizing the sample and then a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20910
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:Diffusion magnetic resonance imaging (MRI) microstructure imaging provides a unique noninvasive probe into tissue microstructure. The technique relies on biophysically motivated mathematical models, relating microscopic tissue features to the magnetic resonance (MR) signal. This work aims to determine which com...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25080
更新日期:2014-12-01 00:00:00
abstract::The application of T1 rho an an alternative contrast parameter in high-field magnetic resonance histology (MRH) has been investigated. Spectroscopic measurements of T1 rho were performed on 5.75% agar and 1.0 mM MnCI2 phantoms at 9.4 T to validate the accuracy of the imaging measurements. Image studies were performed ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350520
更新日期:1996-05-01 00:00:00
abstract:PURPOSE:Imaging gradients result in the generation of concomitant fields, or Maxwell fields, which are of increasing importance at higher gradient amplitudes. These time-varying fields cause additional phase accumulation, which must be compensated for to avoid image artifacts. In the case of gradient systems employing ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26790
更新日期:2018-03-01 00:00:00