Abstract:
:The accurate assessment of pulmonary perfusion is especially important in the evaluation of patients with suspected pulmonary embolism, a common and potentially lethal disorder that can be treated by aggressive anticoagulation. In this study, we demonstrate for the first time the use of MR to image pulmonary perfusion in humans by using dynamic imaging after contrast administration. The technique, which uses an inversion recovery turbo FLASH sequence with ultrashort TE (1.4 ms) and 1-s temporal resolution, was tested in a series of eight healthy subjects and in a porcine model of pulmonary embolism. After the administration of gadopentetate dimeglumine in humans and animal models, there was serial enhancement of the systemic veins, right atrium, right ventricle, and pulmonary arteries. The pulmonary arterial tree was visualized beyond the segmental branches, followed by a gradual diffuse increase in signal intensity of the lung parenchyma over a period of 4.0-7.0 s. Pulmonary circulation times ranged from 3.0-3.4 s. Whereas a high dose (20 or 40 ml) of contrast agent tended to produce the most intense parenchymal enhancement, a low dose (5 ml) was best for showing recirculation. In the animal model, a perfusion defect due to a pulmonary embolus was clearly shown and confirmed by cine angiography. It is concluded that MRI of lung perfusion is feasible. With further development, perfusion MRI could eventually have a significant clinical role in the diagnostic evaluation of pulmonary embolism.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Hatabu H,Gaa J,Kim D,Li W,Prasad PV,Edelman RRdoi
10.1002/mrm.1910360402subject
Has Abstractpub_date
1996-10-01 00:00:00pages
503-8issue
4eissn
0740-3194issn
1522-2594journal_volume
36pub_type
杂志文章abstract::Most prostate MRI/MRS examinations are performed with an endorectal coil inflated with air, leading to an air-tissue interface that induces magnetic susceptibility gradients within the gland. Inflation of the coil with a barium sulfate suspension is described and compared to inflation with air or liquid perfluorocarbo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21166
更新日期:2007-05-01 00:00:00
abstract::Reaching the full potential of magnetic resonance imaging (MRI)-positron emission tomography (PET) dual modality systems requires new methodologies in quantitative image analyses. In this study, methods are proposed to convert an arterial input function (AIF) derived from gadolinium-diethylenetriaminepentaacetic acid ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24318
更新日期:2013-03-01 00:00:00
abstract::Balanced steady-state free precession (SSFP) imaging is sensitive to off-resonance effects, which can lead to considerable artifacts during a transient phase following magnetization preparation or steady-state interruption. In addition, nonlinear k-space encoding is required if contrast-relevant k-space regions need t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20615
更新日期:2005-10-01 00:00:00
abstract::Echo-planar spectroscopic imaging (EPSI) can be used for fast spectroscopic imaging of water and fat resonances at high resolution to improve structural and functional imaging. Because of the use of oscillating gradients during the free induction decay (FID), spectra obtained with EPSI are often degraded by Nyquist gh...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10485
更新日期:2003-06-01 00:00:00
abstract::The preovulatory rat follicle reaches a diameter of 1 mm with no internal blood vessels. Nutrient supply to the enclosed oocyte depends solely on passive diffusion across the follicular wall and the follicular fluid. Spin-echo and stimulated-echo NMR microscopy experiments were applied here for studying modulations in...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910340212
更新日期:1995-08-01 00:00:00
abstract::In vivo or ex vivo electron paramagnetic resonance imaging (EPRI) is a powerful technique for determining the spatial distribution of free radicals and other paramagnetic species in living organs and tissues. However, applications of EPRI have been limited by long projection acquisition times and the consequent fact t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24250
更新日期:2013-02-01 00:00:00
abstract::This review reports data on the general and renal tolerance of the paramagnetic contrast agent Gd-DTPA after intravenous administration. Gd-DTPA was administered usually at a dose level of 0.1-0.2 mmol/kg body wt (range: 0.005-0.25 mmol/kg body wt) in cranial, spinal and body MR indications. In phase I-IIIa studies a ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章,评审
doi:10.1002/mrm.1910220212
更新日期:1991-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate the feasibility of in vivo imaging of human pancreatic ductal cells by OATP1B3 reporter gene under MRI. METHODS:A human cell line (PANC-1) derived from the pancreatic ductal epithelium was used in this study. After transduction of OATP1B3, the cellular physiological...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27749
更新日期:2019-08-01 00:00:00
abstract::MR images acquired by using an arterial spin-labeling technique showed spatial and temporal variations of perfusion in the skeletal muscle of exercising humans. Perfusion measurements made during plantar flexion exercise in normal volunteers were consistent with those obtained by traditional techniques reported in the...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199908)42:2<258::aid-mrm7>
更新日期:1999-08-01 00:00:00
abstract:PURPOSE:To develop a novel technique for voxel-based mapping of lung microstructural parameters using hyperpolarized 129 Xe dissolved-phase MR imaging during saturation recovery. METHODS:A pulse sequence using a highly undersampled stack-of-stars trajectory was developed, and low-rank plus sparse matrix decomposition ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27559
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To present a new method that can simultaneously and efficiently measure T1 and B1 (+) maps using reference region variable flip angle (RR-VFA) imaging. METHODS:Assuming T1 relaxation time in a reference region such as fat is well characterized, and the reference region sufficiently covers smoothly varying B1 (...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24904
更新日期:2013-10-01 00:00:00
abstract::Gadobutrol (Gd-Bt; Gadovist(R), Schering AG) is a 1-M Gadolinium (Gd)-based contrast agent. Its higher Gd concentration allows for reduction of injection volumes in first pass contrast-enhanced MR angiography (CE-MRA) and should increase bolus sharpness and image quality. However, ambivalent results were reported. In ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21345
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To develop and validate a method for choosing the optimal two-dimensional CAIPIRINHA kernel for subtraction contrast-enhanced MR angiography (CE-MRA) and estimate the degree of image quality improvement versus that of some reference acceleration parameter set at R ≥ 8. METHODS:A metric based on patient-specifi...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25366
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To investigate the use of shielded-coaxial-cable (SCC) coils as elements for multi-channel receive-only and transceive arrays for 7T human MRI and to compare their performance with equivalently sized conventional loop coils. METHODS:The SCC coil element consists of a coaxial loop with interrupted central condu...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27964
更新日期:2020-03-01 00:00:00
abstract::The concept of temporal echo multiplexing is defined and used to develop rapid biphasic spin-echo sequences for imaging the heart. Three imaging sequences, based on four-echo and two-echo multiplexing and rapid single echo (i.e., conventional spin-echo imaging), are compared. Preliminary results indicate that two-echo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910110109
更新日期:1989-07-01 00:00:00
abstract:PURPOSE:The purpose of this work was to develop a rapid and robust whole-body fat-water MRI (FWMRI) method using a continuously moving table (CMT) with dynamic field corrections at 3 Tesla. METHODS:CMT FWMRI was developed at 3 Tesla with a multiecho golden angle (GA) radial trajectory and dynamic B0 field shimming. Wh...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25848
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:An increasing number of studies show that magnetic susceptibility in white matter fibers is anisotropic and may be described by a tensor. However, the limited head rotation possible for in vivo human studies leads to an ill-conditioned inverse problem in susceptibility tensor imaging (STI). Here we suggest the ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25322
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:The purpose of this study is to increase the robustness of MR fingerprinting (MRF) toward subject motion. METHODS:A novel reconstruction algorithm, MOtion insensitive MRF (MORF), was developed, which uses an iterative reconstruction based retrospective motion correction approach. Each iteration loops through t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27227
更新日期:2018-12-01 00:00:00
abstract::Magnetization transfer imaging (MT) and localized proton spectroscopy (1H-MRS) were utilized in the evaluation of lesions (high signal abnormalities on T2-weighted images) and normal-appearing white matter (NAWM) in multiple sclerosis (MS). Eleven patients with a clinical diagnosis of MS were independently evaluated w...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910320303
更新日期:1994-09-01 00:00:00
abstract:PURPOSE:To improve the quality and speed of electron paramagnetic resonance imaging (EPRI) acquisition by combining a uniform sampling distribution with spinning gradient acquisition. THEORY AND METHODS:A uniform sampling distribution was derived for spinning gradient EPRI acquisition (uniform spinning sampling, USS) ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24712
更新日期:2014-02-01 00:00:00
abstract::This study presents the detection of [2-(13)C]glucose metabolism in the carboxylic/amide region in the human brain, and demonstrates that the cerebral metabolism of [2-(13)C]glucose can be studied in human subjects in the presence of severe hardware constraints of widely available 3 T clinical scanners and with low-po...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22044
更新日期:2009-09-01 00:00:00
abstract::High-signal artifacts produced by cerebrospinal fluid (CSF) flow can adversely affect fluid-attenuated inversion recovery (FLAIR) imaging of the brain and spinal cord. This study explores the use of a nonslice-selective inversion pulse to eliminate CSF flow artifacts together with a technique called "K-space Reordered...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1198
更新日期:2001-08-01 00:00:00
abstract::Simulations of dynamic susceptibility contrast (DSC) MRI are frequently performed by assuming a certain shape for the input function and the microvascular response function. However, to investigate the influence of parameters that will affect the shape of the input function, a more complex model of the human vasculatu...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10567
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:To design low peak and integrated power simultaneous multislice excitation radiofrequency pulses with transmit field inhomogeneity compensation in high field MRI. THEORY AND METHODS:The "interleaved greedy and local optimization" algorithm for small-tip-angle spokes pulses is extended to design multiband (MB) ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25455
更新日期:2015-09-01 00:00:00
abstract::Using a material that already is in widespread use in humans, India ink, the first EPR measurements in a human have been made, using the India ink in a pre-existing tattoo. The EPR spectra of India ink are very sensitive to the partial pressure of oxygen (pO2), thereby making it feasible to use this approach to measur...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910310218
更新日期:1994-02-01 00:00:00
abstract::A multifocal mouse liver tumor model chemically induced with 5,9-dimethyl-7H-dibenzo[c,g]carbazole was investigated by respiratory-triggered morphological and functional MRI (fMRI) at 4.7 Tesla. The model is characterized by the presence of two tumor types: hypovascular cholangioma and vascularized hepatocellular carc...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10555
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:Compare the transmural distribution of forward creatine kinase reaction (kf,CK ) and ATP hydrolysis rate (kr,ATPase ) in the myocardium of normal porcine heart. Rate constants were extracted from partially relaxed spectra by applying the T1nom method, effectively reducing data acquisition time by up to an order...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26162
更新日期:2016-05-01 00:00:00
abstract::Dynamic MRI tracking of rat T-cells in vivo is performed in rat testicles after labeling isolated rat T-cells in vitro with superparamagnetic dextran-coated iron-oxide particles, BMS180549. Tissue inflammation induced by the local injection of the calcium ionophore, A23187, is used to attract labeled T-cells. Gradient...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910330209
更新日期:1995-02-01 00:00:00
abstract::The changes in the response of skeletal muscle to maximal dynamic exercise were investigated in going from a fasted state to a refed state by means of 31P NMR spectroscopy. It was found that in the fasted state, exercise-induced changes in Pi/PCr and in pH were both inhibited, in comparison with those in the refed sta...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910030616
更新日期:1986-12-01 00:00:00
abstract::A new approach to autocalibrating, coil-by-coil parallel imaging reconstruction, is presented. It is a generalized reconstruction framework based on self-consistency. The reconstruction problem is formulated as an optimization that yields the most consistent solution with the calibration and acquisition data. The appr...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22428
更新日期:2010-08-01 00:00:00