Abstract:
:In vivo or ex vivo electron paramagnetic resonance imaging (EPRI) is a powerful technique for determining the spatial distribution of free radicals and other paramagnetic species in living organs and tissues. However, applications of EPRI have been limited by long projection acquisition times and the consequent fact that rapid gated EPRI was not possible. Hence in vivo EPRI typically provided only time-averaged information. In order to achieve direct gated EPRI, a fast EPR acquisition scheme was developed to decrease EPR projection acquisition time down to 10-20 ms, along with corresponding software and instrumentation to achieve fast gated EPRI of the isolated beating heart with submillimeter spatial resolution in as little as 2-3 min. Reconstructed images display temporal and spatial variations of the free-radical distribution, anatomical structure, and contractile function within the rat heart during the cardiac cycle.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Chen Z,Reyes LA,Johnson DH,Velayutham M,Yang C,Samouilov A,Zweier JLdoi
10.1002/mrm.24250subject
Has Abstractpub_date
2013-02-01 00:00:00pages
594-601issue
2eissn
0740-3194issn
1522-2594journal_volume
69pub_type
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